Abstract
This paper describes the dynamical behavior of an epidemic model in the presence of vaccination and treatment controls. In the first part of our analysis we study both the local as well as global dynamics of the deterministic model. Next in the second part of our analysis we modify the model with an additional perturbation around the endemic equilibrium and study the asymptotically mean square stability of the modified system. Some numerical simulations are carried out on both the deterministic and the modified models to support our analytical results.
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Bernoulli D (1766) Essai d’une nouvelle analyse de la mortalite causee par la petite verole. Mem. math. phy. acad. roy. sci. Paris
Kermack WO, McKendrik AG (1927) Contribution to the mathematical theory of epidemics. Proc R Soc Lond Ser A 115:700–721
Bowong S, Kurths J (2012) Modeling and analysis of the transmission dynamics of tuberculosis without and with seasonality. Nonlinear Dyn 67:2027–2051
Anderson RM, May RM (1991) Infectious diseases in humans: dynamics and control. Oxford University Press, Oxford
Brauer F, van den Driessche P, Wu J (eds) (2008) Mathematical epidemiology. Lecture notes in mathematics. Springer, Berlin
Kar TK, Jana S, Ghorai A (2013) Effect of isolation in an infectious disease. Int J Ecol Econ Stat 29(2):87–106
Rohani P (2008) Modeling infectious diseases in humans and animals. Princeton University Press, Princeton
Xia C, Wang L, Sun S, Wang J (2012) An SIR model with infection delay and propagation vector in complex networks. Nonlinear Dyn 69:927–934
Capasso V (1993) Mathematical structures of epidemic systems. Lecture notes in biomath. Springer, Berlin
Murray JD (2002) Mathematical biology. Springer, Berlin
Zhou X, Cui J (2011) Analysis of stability and bifurcation for an SEIV epidemic model with vaccination and nonlinear incidence rate. Nonlinear Dyn 63:639–653
van den Driessche P, Watmough J (2002) Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. Math Biosci 180:29–48
Diekmann O, Heesterbeek JAP (2000) Mathematical epidemiology of infectious diseases. Model building, analysis and interpretation. Wiley, Chichester
Pang J, Cui J, Hui J (2012) The importance of immune responses in a model of hepatitis B virus. Nonlinear Dyn 67:723–934
Mushayabasa S, Bhunu CP (2011) Modelling the effects of heavy alcohol consumption on the transmission dynamics of gonorrhea. Nonlinear Dyn 66:695–706
Kar TK, Mondal PK (2011) Global dynamics and bifurcation in delayed SIR epidemic model. Nonlinear Anal Real World Appl 12:2058–2068
Kar TK, Jana S (2013) A theoretical study on mathematical modelling of an infectious disease with application of optimal control. BioSystems 111:37–50
Thomasey DH, Martcheva M (2008) Serotype replacement of vertically transmitted diseases through perfect vaccination. J Biol Syst 16(2):255–277
Arino J, Cooke KL, van den Driessche P, Velasco-Hernandez J (2004) An epidemiology model that includes a leaky vaccine with a general waning function. Dyn Syst Ser B 4(2):479–495
Buonomo B, Lacitignola D (2011) On the backward bifurcation of a vaccination model with nonlinear incidence. Nonlinear Anal Model Control 16(1):30–46
Wang W (2006) Backward bifurcation of an epidemic model with treatment. Math Biosci 201:58–71
Cai L, Li X, Ghosh M, Guo B (2009) Stability analysis of an HIV/AIDS epidemic model with treatment. J Comput Appl Math 229:313–323
Zhang X, Liu X (2009) Backward bifurcation and global dynamics of an SIS epidemic model with general incidence rate and treatment. Nonlinear Anal Real World Appl 10:565–575
Eckalbar JC, Eckalbar WL (2011) Dynamics of an epidemic model with quadratic treatment. Nonlinear Anal Real World Appl 12(1):320–332
Gumel AB, Moghadas SM (2003) A qualitative study of a vaccination model with non-linear incidence. Appl Math Comput 143:409–419
Qiu Z, Feng Z (2010) Transmission dynamics of an influenza model with vaccination and antiviral treatment. Bull Math Biol 72(1):1–33
Hu Z, Ma W, Ruan S (2012) Analysis of SIR epidemic models with nonlinear incidence rate and treatment. Math Biosci 238(1):12–20
Kar TK, Jana S (2013) Application of three controls optimally in a vector borne disease—a mathematical study. Commun Nonlinear Sci Numer Simul 18:2868–2884
Brauer F (2011) Backward bifurcations in simple vaccination/treatment models. J Biol Dyn 5(5):410–418
Tchuenche JM, Khamis SA, Agusto FB, Mpeshe SC (2011) Optimal control and sensitivity analysis of an influenza model with treatment and vaccination. Acta Biotheor 59(1):1–28
Hamer WH (1906) Epidemic disease in England. Lancet 1: 733–739
Ma Z, Li J (eds) (2009) Dynamical modeling and analysis of epidemics. World Scientific, Singapore
Junjie C (2004) An sirs epidemic model. Appl Math A J Chin Univ 19(1):101–108
Okosun KO, Ouifki R, Marcus N (2011) Optimal control analysis of a malaria disease transmission model that includes treatment and vaccination with waning immunity. Biosystems 106:136–145
Sahu GP, Dhar J (2012) Analysis of an SVEIS epidemic model with partial temporary immunity and saturation incidence rate. Appl Math Model 36:908–923
Song L-P, Jin Z, Sun G-Q (2011) Reinfection induced disease in a spatial SIRI model. J Biol Phys 37:133–140
Buonomo B, Rionero S (2010) On the Lyapunov stability for SIRS epidemic models with general nonlinear incidence rate. Appl Math Comput 217:4010–4016
Birkoff G, Rota GC (1982) Ordinary differential equations. Ginn, Boston
Guckenheimer G, Holmes P (1983) Nonlinear oscillations, dynamical systems, and bifurcations of vector fields. Springer, New York
Li MY, Muldowney JS (1996) A geometric approach to global stability problems. SIAM J Math Anal 27(4):1070–1083
Martin RH Jr (1974) Logarithmic norms and projections applied to linear differential systems. J Math Anal Appl 45:432–454
Lahrouz A, Omari L, Kiouach D (2011) Global analysis of a deterministic and stochastic nonlinear SIRS epidemic model. Nonlinear Anal Model Control 16(1):69–76
Sarkar RR, Banerjee S (2005) Cancer self remission and tumor stability a stochastic approach. Math Biosci 196:65–81
Huang Z, Yang Q, Cao J (2011) Complex dynamics in a stochastic internal HIV model. Chaos Solitons Fractals 44:954–963
Beretta E, Kolmanovskii V, Shaikhet L (1998) Stability of epidemic model with time delays influenced by stochastic perturbations. Math Comput Simul 45:269–277
Mao X (2007) Stochastic differential equation and application (second edition)
Afanasev VN, Kolmanowskii VB, Nosov VR (1996) Mathematical theory of control systems design. Kluwer, Dordrecht
Cai L, Li X (2008) A note on global stability of an SEI epidemic model with acute and chronic stages. Appl Math Comput 196:923–930
Li X, Wanga J, Ghosh M (2010) Stability and bifurcation of an SIVS epidemic model with treatment and age of vaccination. Appl Math Model 34:437–450
Acknowledgments
The research of T. K. Kar is partially supported by the Council of Scientific and Industrial Research (CSIR) (Grant No.: 25(0224)/14/EMR II, dated December 2, 2014). Further, the authors are very much grateful to the anonymous reviewers for their constructive comments and helpful suggestions to improve the manuscript significantly.
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Jana, S., Haldar, P. & Kar, T.K. Complex dynamics of an epidemic model with vaccination and treatment controls. Int. J. Dynam. Control 4, 318–329 (2016). https://doi.org/10.1007/s40435-015-0189-7
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DOI: https://doi.org/10.1007/s40435-015-0189-7