Skip to main content
Log in

Olanzapine and clozapine use in a woman with schizophrenia during consecutive pregnancies: a case report

  • Short Communication
  • Published:
Drugs & Therapy Perspectives Aims and scope Submit manuscript

Abstract

Data on the safety of antipsychotic use during pregnancy remain inconclusive. Here, we report the history of a woman with schizophrenia who had two pregnancies while receiving prolactin-sparing antipyschotic drugs. The case supports existing data showing that the use of olanzapine and clozapine (on separate occasions) during pregnancy results in uncomplicated deliveries of healthy infants.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Laursen TM, Munk-Olsen T. Reproductive patterns in psychotic patients. Schizophr Res. 2010;121(1–3):234–40.

    Article  CAS  PubMed  Google Scholar 

  2. Jobe TH, Harrow M. Long-term outcome of patients with schizophrenia: a review. Can J Psychiatry. 2005;50(14):892–900.

    PubMed  Google Scholar 

  3. Jones I, Chandra PS, Dazzan P, et al. Bipolar disorder, affective psychosis, and schizophrenia in pregnancy and the post-partum period. Lancet. 2014;384(9956):1789–99.

    Article  PubMed  Google Scholar 

  4. Miller LJ, Finnerty M. Sexuality, pregnancy, and childrearing among women with schizophrenia-spectrum disorders. Psychiatr Serv. 1996;47(5):502–6.

    Article  CAS  PubMed  Google Scholar 

  5. Gentile S. Antipsychotic therapy during early and late pregnancy: a systematic review. Schizophr Bull. 2010;36(3):518–44.

    Article  PubMed  Google Scholar 

  6. Raha S, Taylor VH, Holloway AC. Effect of atypical antipsychotics on fetal growth: is the placenta involved? J Pregnancy. 2012;2012:315203.

    Article  PubMed  PubMed Central  Google Scholar 

  7. McCauley-Elsom K, Gurvich C, Elsom SJ, et al. Antipsychotics in pregnancy. J Psychiatr Ment Health Nurs. 2010;17(2):97–104.

    Article  CAS  PubMed  Google Scholar 

  8. Lin HC, Chen IJ, Chen YH, et al. Maternal schizophrenia and pregnancy outcome: does the use of antipsychotics make a difference? Schizophr Res. 2010;116(1):55–60.

    Article  PubMed  Google Scholar 

  9. Brunner E, Falk DM, Jones M, et al. Olanzapine in pregnancy and breastfeeding: a review of data from global safety surveillance. BMC Pharmacol Toxicol. 2013;14:38.

    Article  CAS  PubMed  Google Scholar 

  10. Arora M, Praharaj SK. Meningocele and ankyloblepharon following in utero exposure to olanzapine. Eur Psychiatry. 2006;21(5):345–6.

    Article  CAS  PubMed  Google Scholar 

  11. McKenna K, Koren G, Tetelbaum M, et al. Pregnancy outcome of women using atypical antipsychotic drugs: a prospective comparative study. J Clin Psychiatry. 2005;66(4):444–9.

    Article  CAS  PubMed  Google Scholar 

  12. Goldstein DJ, Corbin LA, Fung MC. Olanzapine-exposed pregnancies and lactation: early experience. J Clin Psychopharmacol. 2000;20(4):399–403.

    Article  CAS  PubMed  Google Scholar 

  13. Spyropoulou AC, Zervas IM, Soldatos CR. Hip dysplasia following a case of olanzapine exposed pregnancy: a questionable association. Arch Womens Ment Health. 2006;9(4):219–22.

    Article  CAS  PubMed  Google Scholar 

  14. Yeshayahu Y. The use of olanzapine in pregnancy and congenital cardiac and musculoskeletal abnormalities. Am J Psychiatry. 2007;164(11):1759–60.

    Article  PubMed  Google Scholar 

  15. McMahon DM, Liu J, Zhang H, et al. Maternal obesity, folate intake, and neural tube defects in offspring. Birth Defects Res A Clin Mol Teratol. 2013;97(2):115–22.

    Article  CAS  PubMed  Google Scholar 

  16. Newport DJ, Calamaras MR, DeVane CL, et al. Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomes. Am J Psychiatry. 2007;164(8):1214–20.

    Article  PubMed  Google Scholar 

  17. Vavrusova L, Konikova M. Clozapine administration during pregnancy [in Czechoslovakian]. Ceska Slov Psychiatr. 1998;94:282–5.

    Google Scholar 

  18. Karakula H, Szajer K, Rpila B, et al. Clozapine and pregnancy: a case history. Pharmacopsychiatry. 2004;37(6):303–4.

    Article  CAS  PubMed  Google Scholar 

  19. Gentile S. Pregnancy exposure to second-generation antipsychotics and the risk of gestational diabetes. Expert Opin Drug Saf. 2014;13(12):1583–90.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

Informed consent was obtained from the patient’s legal guardian.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rugül Köse Çınar.

Ethics declarations

Conflict of interest

Rugül Köse Çinar declares no conflicts of interest.

Funding

No sources of funding were used in the preparation of the manuscript.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Köse Çınar, R. Olanzapine and clozapine use in a woman with schizophrenia during consecutive pregnancies: a case report. Drugs Ther Perspect 32, 403–405 (2016). https://doi.org/10.1007/s40267-016-0328-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40267-016-0328-z

Keywords

Navigation