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Hip dysplasia following a case of olanzapine exposed pregnancy: a questionable association

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Summary

This is a case report of a 33 year old woman with a history of psychosis, who presented to the women’s mental health clinic for consultation at the 12th week of gestation, having already received olanzapine throughout the first trimester. She was followed from that point on at our clinic and remained on small doses of olanzapine for the rest of her pregnancy, which was uncomplicated. She gave birth to a healthy female, which at the age of three months was diagnosed with developmental dysplasia of the hip and subsequently received appropriate treatment with favorable outcome. The possibility of the association of this congenital dysplasia with the use of olanzapine during pregnancy is further discussed in this paper.

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References

  • InstitutionalAuthorNameAmerican Academy of Paediatrics (2002) ArticleTitleClinical practice guideline: early detection of developmental dysplasia of the hip. Committee on Quality Improvement, Subcommittee on Developmental Dysplasia of the Hip Paediatrics 105 896–905

    Google Scholar 

  • Arona M, Praharaj SK (2006) Meningocele and ankyloblepharon following in utero exposure to olanzapine. Europ Psychiatry (in press).

  • BE Bennedsen PB Mortensen AV Olesen TB Henriksen (1999) ArticleTitlePreterm birth and intra-uterine growth retardation among children of women with schizophrenia Br J Psychiatry 175 239–245 Occurrence Handle10645325 Occurrence Handle1:STN:280:DC%2BD3c7gvF2hsg%3D%3D Occurrence Handle10.1192/bjp.175.3.239

    Article  PubMed  CAS  Google Scholar 

  • BE Bennedsen PB Mortensen AV Olesen TB Henriksen (2001) ArticleTitleCongenital malformations, stillbirths, and infant deaths among children of women with schizophrenia Arch Gen Psychiatry 58 674–679 Occurrence Handle11448375 Occurrence Handle1:STN:280:DC%2BD3Mvisl2luw%3D%3D Occurrence Handle10.1001/archpsyc.58.7.674

    Article  PubMed  CAS  Google Scholar 

  • PN Biswasl LV Wilton GL Pearcel S Freemantle SA Shakir (2001) ArticleTitleThe pharmacovigilance of olanzapine: results of a post-marketing surveillance study on 8858 patients in England J Psychopharmacol 15 265–271 Occurrence Handle11769820 Occurrence Handle1:STN:280:DC%2BD38%2FktlKhtg%3D%3D Occurrence Handle10.1177/026988110101500405

    Article  PubMed  CAS  Google Scholar 

  • SH Chay JL Herman (1998) ArticleTitleDisposition of the novel anti-schizophrenic drug [14C]olanzapine in male Fischer 344 and female CD rats following single oral dose administration Arzneimittelforschung 48 446–454 Occurrence Handle9638310 Occurrence Handle1:CAS:528:DyaK1cXjtlyiu70%3D

    PubMed  CAS  Google Scholar 

  • RA Dickson DT Dawson (1998) ArticleTitleOlanzapine and pregnancy Can J Psychiatry 43 196–197 Occurrence Handle9533978 Occurrence Handle1:STN:280:DyaK1c7psFClsA%3D%3D

    PubMed  CAS  Google Scholar 

  • CL Ernst JF Goldberg (2002) ArticleTitleThe reproductive safety profile of mood stabilizers, atypical antipsychotics, and broad-spectrum psychotropics J Clin Psychiatry 63 IssueID[Suppl 4] 42–55 Occurrence Handle11913676 Occurrence Handle1:CAS:528:DC%2BD38XivFCqt7o%3D

    PubMed  CAS  Google Scholar 

  • French LM, Dietz FR (1999) Screening for developmental dysplasia of the hip. Am Fam Physician 60: 178–184, 187–188.

    Google Scholar 

  • SH Friedman MB Rosenthal (2003) ArticleTitleTreatment of perinatal delusional disorder: a case report Int J Psychiatry Med 33 391–394 Occurrence Handle15152788 Occurrence Handle10.2190/MTXF-06M3-DBFE-WPQJ

    Article  PubMed  Google Scholar 

  • S Gentile (2004) ArticleTitleClinical utilization of atypical antipsychotics in pregnancy and lactation Ann Pharmacother 38 1265–1271 Occurrence Handle15150376 Occurrence Handle1:CAS:528:DC%2BD2cXlvFems7o%3D Occurrence Handle10.1345/aph.1D485

    Article  PubMed  CAS  Google Scholar 

  • DJ Goldstein LA Corbin MC Fung (2000) ArticleTitleOlanzapine-exposed pregnancies and lactation: early experience J Clin Psychopharmacol 20 399–403 Occurrence Handle10917399 Occurrence Handle1:CAS:528:DC%2BD3cXlsFymt7g%3D Occurrence Handle10.1097/00004714-200008000-00002

    Article  PubMed  CAS  Google Scholar 

  • H Hosojima T Togo T Odawara K Hasegawa S Miura Y Kato A Kanai A Kase H Uchikado Y Hirayasu (2006) ArticleTitleEarly effects of olanzapine on serum levels of ghrelin, adiponectin and leptin in patients with schizophrenia J Psychopharmacol 20 75–79 Occurrence Handle16204328 Occurrence Handle1:CAS:528:DC%2BD28Xit1alurs%3D Occurrence Handle10.1177/0269881105056647

    Article  PubMed  CAS  Google Scholar 

  • AV Jablensky V Morgan SR Zubrick C Bower LA Yellachich (2005) ArticleTitlePregnancy, delivery, and neonatal complications in a population cohort of women with schizophrenia and major affective disorders Am J Psychiatry 162 79–91 Occurrence Handle15625205 Occurrence Handle10.1176/appi.ajp.162.1.79

    Article  PubMed  Google Scholar 

  • J Kirchheiner A Berghofer D Bolk-Weischedel (2000) ArticleTitleHealthy outcome under olanzapine treatment in a pregnant woman Pharmacopsychiatry 33 78–80 Occurrence Handle10761825 Occurrence Handle1:STN:280:DC%2BD3c3it1ClsA%3D%3D Occurrence Handle10.1055/s-2000-7974

    Article  PubMed  CAS  Google Scholar 

  • LM Lim (2001) ArticleTitleOlanzapine and pregnancy Aust NZ J Psychiatry 35 856–857 Occurrence Handle1:STN:280:DC%2BD383kvFKluw%3D%3D Occurrence Handle10.1046/j.1440-1614.2001.0971e.x

    Article  CAS  Google Scholar 

  • KH Littrell CG Johnson CD Peabody N Hilligoss (2000) ArticleTitleAntipsychotics during pregnancy Am J Psychiatry 157 1342 Occurrence Handle10910807 Occurrence Handle1:STN:280:DC%2BD3cvgvVemtQ%3D%3D Occurrence Handle10.1176/appi.ajp.157.8.1342

    Article  PubMed  CAS  Google Scholar 

  • P Malek-Ahmadi (2001) ArticleTitleOlanzapine in pregnancy Ann Pharmacother 35 1294–1295 Occurrence Handle11675867 Occurrence Handle1:STN:280:DC%2BD3MrmvFCmsA%3D%3D Occurrence Handle10.1345/aph.1Z428

    Article  PubMed  CAS  Google Scholar 

  • K McKenna G Koren M Tetelbaum L Wilton S Shakir O Diav-Citrin A Levinson RB Zipursky A Einarson (2005) ArticleTitlePregnancy outcome of women using atypical antipsychotic drugs: a prospective comparative study J Clin Psychiatry 66 444–449 Occurrence Handle15816786 Occurrence Handle1:CAS:528:DC%2BD2MXktlWqs74%3D Occurrence Handle10.4088/JCP.v66n0406

    Article  PubMed  CAS  Google Scholar 

  • KI Melkersson AL Hutling KE Brismar (2000) ArticleTitleElevated levels of insulin, leptin and blood lipids in olanzapine-treated patients with schizophrenia or related psychoses J Clin Psychiatry 62 742–749

    Google Scholar 

  • DN Mendhekar L War JB Sharma RC Jiloha (2002) ArticleTitleOlanzapine and pregnancy Pharmacopsychiatry 35 122–123 Occurrence Handle12107859 Occurrence Handle1:STN:280:DC%2BD38zmt1KgtQ%3D%3D Occurrence Handle10.1055/s-2002-31519

    Article  PubMed  CAS  Google Scholar 

  • M Murashita I Kusumi T Inoue Y Takahashi H Hosoda K Kangawa T Koyama (2005) ArticleTitleOlanzapine increases plasma ghrelin level in patients with schizophrenia Psychoneuroendocrinology 30 106–110 Occurrence Handle15358448 Occurrence Handle1:CAS:528:DC%2BD2cXnsVyqsr8%3D Occurrence Handle10.1016/j.psyneuen.2004.05.008

    Article  PubMed  CAS  Google Scholar 

  • A Nagy T Tenyi K Lenard R Herold F Wilhelm M Trixler (2001) ArticleTitleOlanzapine and pregnancy Orv Hetil 142 137–138 Occurrence Handle11217163 Occurrence Handle1:STN:280:DC%2BD3M7ptlymsQ%3D%3D

    PubMed  CAS  Google Scholar 

  • NU Neumann K Frasch (2001) ArticleTitleOlanzapine and pregnancy. 2 case reports Nervenarzt 72 876–878 Occurrence Handle11758096 Occurrence Handle1:STN:280:DC%2BD38%2Fjt1ehsw%3D%3D Occurrence Handle10.1007/s001150170023

    Article  PubMed  CAS  Google Scholar 

  • E Nillson P Lichtenstein S Cnattingius RM Murray CM Hultman (2002) ArticleTitleWomen with schizophrenia: pregnancy outcome and infant death among their offspring Schizophr Res 58 221–229 Occurrence Handle10.1016/S0920-9964(01)00370-X

    Article  Google Scholar 

  • A Sacker DJ Done TJ Crow (1996) ArticleTitleObstetric complications in children born to parents with schizophrenia: a meta-analysis of case-control studies Psychol Med 26 279–287 Occurrence Handle8685284 Occurrence Handle1:STN:280:DyaK283ktlCisg%3D%3D Occurrence Handle10.1017/S003329170003467X

    Article  PubMed  CAS  Google Scholar 

  • S Schenker Y Yang E Mattiuz D Tatum M Lee (1999) ArticleTitleOlanzapine transfer by human placenta Clin Exp Pharmacol Physiol 26 691–697 Occurrence Handle10499158 Occurrence Handle1:CAS:528:DyaK1MXmtFCntrk%3D Occurrence Handle10.1046/j.1440-1681.1999.03111.x

    Article  PubMed  CAS  Google Scholar 

  • SA Shipman M Helfand VA Moyer BP Yawn (2006) ArticleTitleScreening for the developmental dysplasia of the hip: A systematic literature review of the US preventive services task force Paediatrics 117 e557–e576 Occurrence Handle10.1542/peds.2005-1597

    Article  Google Scholar 

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Spyropoulou, A., Zervas, I. & Soldatos, C. Hip dysplasia following a case of olanzapine exposed pregnancy: a questionable association. Arch Womens Ment Health 9, 219–222 (2006). https://doi.org/10.1007/s00737-006-0138-8

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  • DOI: https://doi.org/10.1007/s00737-006-0138-8

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