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Primary Localized Cutaneous Amyloidosis: A Systematic Treatment Review

  • Systematic Review
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American Journal of Clinical Dermatology Aims and scope Submit manuscript

Abstract

Background

Primary localized cutaneous amyloidosis (PLCA) is characterized by extracellular deposition of heterogenic amyloid proteins in the skin without systemic involvement. Lichen amyloidosis, macular amyloidosis, and (primary localized cutaneous) nodular amyloidosis are different subtypes of PLCA.

Objective

The aim of this study was to review the current reported treatment options for PLCA.

Methods

This systematic review was based on a search in the PubMed database for English and German articles from 1985 to 2016.

Results

Reports on the treatment of PLCA were limited predominantly to case reports or small case series. There were a few clinical trials but these lacked control groups. A variety of treatment options for PLCA were reported including retinoids, corticosteroids, cyclophosphamide, cyclosporine, amitriptyline, colchicine, cepharanthin, tacrolimus, dimethyl sulfoxide, vitamin D3 analogs, capsaicin, menthol, hydrocolloid dressings, surgical modalities, laser treatment, and phototherapy.

Conclusion

No definitive recommendation of preferable treatment procedures can be made based on the analyzed literature. Randomized controlled trials are needed to offer patients an evidence-based therapy with high-quality standardized treatment regimens for PLCA.

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References

  1. Fernandez-Flores A. Cutaneous amyloidosis: a concept review. Am J Dermatopathol. 2012;34(1):1–14 (quiz 5–7). doi:10.1097/DAD.0b013e31823465c7.

  2. Brownstein MH, Hashimoto K, Greenwald G. Biphasic amyloidosis: link between macular and lichenoid forms. Arch Dermatol. 1972;106(3):419.

    CAS  PubMed  Google Scholar 

  3. Ollague W. Primary cutaneous amyloidosis. Int J Dermatol. 1987;26(2):135.

    CAS  PubMed  Google Scholar 

  4. Breathnach SM. Amyloid and amyloidosis. J Am Acad Dermatol. 1988;18(1 Pt 1):1–16.

    CAS  PubMed  Google Scholar 

  5. Huilgol SC, Ramnarain N, Carrington P, et al. Cytokeratins in primary cutaneous amyloidosis. Australas J Dermatol. 1998;39(2):81–5.

    CAS  PubMed  Google Scholar 

  6. Brownstein MH, Hashimoto K. Macular amyloidosis. Arch Dermatol. 1972;106(1):50–7.

    CAS  PubMed  Google Scholar 

  7. Ramirez-Santos A, Labandeira J, Monteagudo B, Toribio J. Lichen amyloidosus without itching indicates that it is not secondary to chronic scratching. Acta Derm Venereol. 2006;86(6):561–2. doi:10.2340/00015555-0155.

    PubMed  Google Scholar 

  8. Schreml S, Szeimies RM, Vogt T, et al. Cutaneous amyloidoses and systemic amyloidoses with cutaneous involvement. Eur J Dermatol. 2010;20(2):152–60. doi:10.1684/ejd.2010.0842.

    PubMed  Google Scholar 

  9. Woollons A, Black MM. Nodular localized primary cutaneous amyloidosis: a long-term follow-up study. Br J Dermatol. 2001;145(1):105–9.

    CAS  PubMed  Google Scholar 

  10. Ollague W, Ollague J, Ferretti H. Epidemiology of primary cutaneous amyloidoses in South America. Clin Dermatol. 1990;8(2):25–9.

    CAS  PubMed  Google Scholar 

  11. McDonald RR, Georgouras KE. Skin disorders in Indo-Chinese immigrants. Med J Aust. 1992;157(4):288.

    CAS  PubMed  Google Scholar 

  12. Tan T. Epidemiology of primary cutaneous amyloidoses in southeast Asia. Clin Dermatol. 1990;8(2):20–4.

    CAS  PubMed  Google Scholar 

  13. Tanaka A, Arita K, Lai-Cheong JE, et al. New insight into mechanisms of pruritus from molecular studies on familial primary localized cutaneous amyloidosis. Br J Dermatol. 2009;161(6):1217–24. doi:10.1111/j.1365-2133.2009.09311.x.

    CAS  PubMed  Google Scholar 

  14. Tey HL, Yosipovitch G. Itch in ethnic populations. Acta Derm Venereol. 2010;90(3):227–34. doi:10.2340/00015555-0867.

    PubMed  Google Scholar 

  15. Lin MW, Lee DD, Liu TT, et al. Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. Eur J Hum Genet. 2010;18(1):26–32. doi:10.1038/ejhg.2009.135.

    CAS  PubMed  Google Scholar 

  16. Hashimoto K, Ito K, Kumakiri M, Headington J. Nylon brush macular amyloidosis. Arch Dermatol. 1987;123(5):633–7.

    CAS  PubMed  Google Scholar 

  17. Macsween RM, Saihan EM. Nylon cloth macular amyloidosis. Clin Exp Dermatol. 1997;22(1):28–9.

    CAS  PubMed  Google Scholar 

  18. Somani VK, Hari S, Sita VN, Razvi F. Nylon friction dermatitis: a distinct subset of macular amyloidosis. Indian J Dermatol Venereol Leprol. 1995;61(3):145–7.

    CAS  PubMed  Google Scholar 

  19. Yoshida A, Takahashi K, Tagami H, Akasaka T. Lichen amyloidosis induced on the upper back by long-term friction with a nylon towel. J Dermatol. 2009;36(1):56–9. doi:10.1111/j.1346-8138.2008.00586.x.

    PubMed  Google Scholar 

  20. Venkataram MN, Bhushnurmath SR, Muirhead DE, Al-Suwaid AR. Frictional amyloidosis: a study of 10 cases. Australas J Dermatol. 2001;42(3):176–9.

    CAS  PubMed  Google Scholar 

  21. Verga U, Fugazzola L, Cambiaghi S, et al. Frequent association between MEN 2A and cutaneous lichen amyloidosis. Clin Endocrinol. 2003;59(2):156–61.

    CAS  Google Scholar 

  22. Fritsch PO. Retinoids in psoriasis and disorders of keratinization. J Am Acad Dermatol. 1992;27(6 Pt 2):S8–14.

    CAS  PubMed  Google Scholar 

  23. Atacan D, Ergin C, Celik G, et al. Oral isotretinoin: a new treatment alternative for generalized lichen amyloidosis. Australas J Dermatol. 2016;57(3):246–7. doi:10.1111/ajd.12316.

    PubMed  Google Scholar 

  24. Carlesimo M, Narcisi A, Orsini D, et al. A case of lichen amyloidosus treated with acitretin. Clin Ter. 2011;162(2):e59–61.

    CAS  PubMed  Google Scholar 

  25. Choi JY, Sippe J, Lee S. Acitretin for lichen amyloidosus. Australas J Dermatol. 2008;49(2):109–13. doi:10.1111/j.1440-0960.2008.00434.x.

    PubMed  Google Scholar 

  26. David M, Ingber A, Ben-Chetrit A, et al. Effect of etretinate on lichen amyloidosus. Dermatologica. 1987;175(6):302–3.

    CAS  PubMed  Google Scholar 

  27. Helander I, Hopsu-Havu VK. Treatment of lichen amyloidosus by etretinate. Clin Exp Dermatol. 1986;11(6):574–8.

    CAS  PubMed  Google Scholar 

  28. Marschalko M, Daroczy J, Soos G. Etretinate for the treatment of lichen amyloidosis. Arch Dermatol. 1988;124(5):657–9.

    CAS  PubMed  Google Scholar 

  29. Reider N, Sepp N, Fritsch P. Remission of lichen amyloidosus after treatment with acitretin. Dermatology. 1997;194(3):309–11.

    CAS  PubMed  Google Scholar 

  30. Tietze JK, Heppt MV, Flaig MJ, Thomas P. Successful treatment of lichen amyloidosus with oral alitretinoin. J Eur Acad Dermatol Venereol. 2016;30(5):884–5. doi:10.1111/jdv.13048.

    CAS  PubMed  Google Scholar 

  31. Aram H. Failure of etretinate (RO 10-9359) in lichen amyloidosus. Int J Dermatol. 1986;25(3):206.

    CAS  PubMed  Google Scholar 

  32. Hernandez-Nunez A, Dauden E, Moreno de Vega MJ, et al. Widespread biphasic amyloidosis: response to acitretin. Clin Exp Dermatol. 2001;26(3):256–9.

    CAS  PubMed  Google Scholar 

  33. Terao M, Nishida K, Murota H, Katayama I. Clinical effect of tocoretinate on lichen and macular amyloidosis. J Dermatol. 2011;38(2):179–84. doi:10.1111/j.1346-8138.2010.00962.x.

    PubMed  Google Scholar 

  34. Rados J, Marinovic Kulisic S, Lipozencic J, et al. Macular amyloidosis: a case report. Acta Dermatovenerol Croat. 2008;16(3):138–41.

    PubMed  Google Scholar 

  35. de Argila D, Ortiz-Romero PL, Ortiz-Frutos J, et al. Cutaneous macular amyloidosis associated with multiple endocrine neoplasia 2A. Clin Exp Dermatol. 1996;21(4):313–4.

    PubMed  Google Scholar 

  36. Parish JL. Topical vitamin D3 analogues: unapproved uses, dosages, or indications. Clin Dermatol. 2002;20(5):558–62.

    PubMed  Google Scholar 

  37. Khoo BP, Tay YK, Goh CL. Calcipotriol ointment vs. betamethasone 17-valerate ointment in the treatment of lichen amyloidosis. Int J Dermatol. 1999;38(7):539–41.

    CAS  PubMed  Google Scholar 

  38. Gupta R, Gupta S. Dexamethasone cyclophosphamide pulse therapy in lichen amyloidosus: a case report. J Dermatol Treat. 2007;18(4):249–51. doi:10.1080/09546630701271799.

    CAS  Google Scholar 

  39. Tong PL, Walker WA, Glancy RJ, et al. Primary localized cutaneous nodular amyloidosis successfully treated with cyclophosphamide. Australas J Dermatol. 2013;54(1):e12–5. doi:10.1111/j.1440-0960.2011.00770.x.

    PubMed  Google Scholar 

  40. Das J, Gogoi RK. Treatment of primary localised cutaneous amyloidosis with cyclophosphamide. Indian J Dermatol Venereol Leprol. 2003;69(2):163–4.

    CAS  PubMed  Google Scholar 

  41. Jin AG, Por A, Wee LK, et al. Comparative study of phototherapy (UVB) vs. photochemotherapy (PUVA) vs. topical steroids in the treatment of primary cutaneous lichen amyloidosis. Photodermatol Photoimmunol Photomed. 2001;17(1):42–3.

    CAS  PubMed  Google Scholar 

  42. Behr FD, Levine N, Bangert J. Lichen amyloidosis associated with atopic dermatitis: clinical resolution with cyclosporine. Arch Dermatol. 2001;137(5):553–5.

    CAS  PubMed  Google Scholar 

  43. Cho TH, Lee MH. A case of lichen amyloidosus accompanied by vesicles and dyschromia. Clin Exp Dermatol. 2008;33(3):291–3. doi:10.1111/j.1365-2230.2007.02653.x.

    PubMed  Google Scholar 

  44. Teraki Y, Katsuta M, Shiohara T. Lichen amyloidosus associated with Kimura’s disease: successful treatment with cyclosporine. Dermatology. 2002;204(2):133–5. doi:10.1159/000051831.

    CAS  PubMed  Google Scholar 

  45. Kang MJ, Kim HS, Kim HO, Park YM. A case of atopic dermatitis-associated lichen amyloidosis successfully treated with oral cyclosporine and narrow band UVB therapy in succession. J Dermatol Treat. 2009;20(6):368–70. doi:10.3109/09546630802691325.

    CAS  Google Scholar 

  46. Simpson D, Noble S. Tacrolimus ointment: a review of its use in atopic dermatitis and its clinical potential in other inflammatory skin conditions. Drugs. 2005;65(6):827–58.

    CAS  PubMed  Google Scholar 

  47. Castanedo-Cazares JP, Lepe V, Moncada B. Lichen amyloidosis improved by 0.1% topical tacrolimus. Dermatology. 2002;205(4):420–1. doi:10.1159/000066426.

    PubMed  Google Scholar 

  48. Chakravarty K, Chanda M. Role of colchicine in primary localised cutaneous amyloidosis. Indian J Dermatol Venereol Leprol. 1995;61(5):268–9.

    CAS  PubMed  Google Scholar 

  49. Schattner A. Colchicine: expanding horizons. Postgrad Med J. 1991;67(785):223–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  50. Capriotti K, Capriotti JA. Dimethyl sulfoxide: history, chemistry, and clinical utility in dermatology. J Clin Aesthet Dermatol. 2012;5(9):24–6.

    PubMed  PubMed Central  Google Scholar 

  51. Monfrecola G, Iandoli R, Bruno G, Martellotta D. Lichen amyloidosus: a new therapeutic approach. Acta Derm Venereol. 1985;65(5):453–5.

    CAS  PubMed  Google Scholar 

  52. Pravata G, Pinto G, Bosco M, et al. Unusual localization of lichen amyloidosus: topical treatment with dimethylsulfoxide. Acta Derm Venereol. 1989;69(3):259–60.

    CAS  PubMed  Google Scholar 

  53. Kobayashi T, Yamasaki Y, Watanabe T, Onoda N. Extensive lichen amyloidosus refractory to DMSO. J Dermatol. 1995;22(10):755–8.

    CAS  PubMed  Google Scholar 

  54. Ozkaya-Bayazit E, Kavak A, Gungor H, Ozarmagan G. Intermittent use of topical dimethyl sulfoxide in macular and papular amyloidosis. Int J Dermatol. 1998;37(12):949–54.

    CAS  PubMed  Google Scholar 

  55. Pandhi R, Kaur I, Kumar B. Lack of effect of dimethylsulphoxide in cutaneous amyloidosis. J Dermatol Treat. 2002;13(1):11–4. doi:10.1080/09546630252775180.

    CAS  Google Scholar 

  56. Bautista DM, Wilson SR, Hoon MA. Why we scratch an itch: the molecules, cells and circuits of itch. Nat Neurosci. 2014;17(2):175–82. doi:10.1038/nn.3619.

    CAS  PubMed  PubMed Central  Google Scholar 

  57. Zeidler C, Metze D, Stander S. Successful treatment of lichen amyloidosis using capsaicin 8% patch. J Eur Acad Dermatol Venereol. 2016;30(7):1236–8. doi:10.1111/jdv.13165.

    CAS  PubMed  Google Scholar 

  58. Galeotti N, Di Cesare Mannelli L, Mazzanti G, et al. Menthol: a natural analgesic compound. Neurosci Lett. 2002;322(3):145–8.

    CAS  PubMed  Google Scholar 

  59. Frolich M, Enk A, Diepgen TL, Weisshaar E. Successful treatment of therapy-resistant pruritus in lichen amyloidosis with menthol. Acta Derm Venereol. 2009;89(5):524–6. doi:10.2340/00015555-0725.

    PubMed  Google Scholar 

  60. Hallel-Halevy D, Finkelstein E, Grunwald MH, Halevy S. Lichen amyloidosus treated by hydrocolloid dressings. J Eur Acad Dermatol Venereol. 2004;18(6):691–2. doi:10.1111/j.1468-3083.2004.00940.x.

    CAS  PubMed  Google Scholar 

  61. Weyers W, Weyers I, Bonczkowitz M, et al. Lichen amyloidosus: a consequence of scratching. J Am Acad Dermatol. 1997;37(6):923–8.

    CAS  PubMed  Google Scholar 

  62. David M, Lowe NJ. Psoriasis therapy: comparative studies with a hydrocolloid dressing, plastic film occlusion, and triamcinolone acetonide cream. J Am Acad Dermatol. 1989;21(3 Pt 1):511–4.

    CAS  PubMed  Google Scholar 

  63. Yew YW, Tey HL. Itch in familial lichen amyloidosis: effective treatment with amitriptyline in two cases. Dermatol Ther. 2014;27(1):12–5. doi:10.1111/dth.12023.

    PubMed  Google Scholar 

  64. Gupta MA, Gupta AK. Antidepressant drugs in dermatology. Skin Ther Lett. 2001;6(8):3–5.

    CAS  Google Scholar 

  65. Al Yahya RS. Treatment of primary cutaneous amyloidosis with laser: a review of the literature. Lasers Med Sci. 2016;31(5):1027–35. doi:10.1007/s10103-016-1917-8.

    PubMed  Google Scholar 

  66. Norisugi O, Yamakoshi T, Shimizu T. Successful treatment of lichen amyloidosis using a CO2 surgical laser. Dermatol Ther. 2014;27(2):71–3. doi:10.1111/dth.12057.

    PubMed  Google Scholar 

  67. Esmat SM, Fawzi MM, Gawdat HI, et al. Efficacy of different modes of fractional CO2 laser in the treatment of primary cutaneous amyloidosis: a randomized clinical trial. Lasers Surg Med. 2015;47(5):388–95. doi:10.1002/lsm.22361.

    PubMed  Google Scholar 

  68. Truhan AP, Garden JM, Roenigk HH Jr. Nodular primary localized cutaneous amyloidosis: immunohistochemical evaluation and treatment with the carbon dioxide laser. J Am Acad Dermatol. 1986;14(6):1058–62.

    CAS  PubMed  Google Scholar 

  69. Lesiak A, Rakowski A, Brzezinska A, et al. Effective treatment of nodular amyloidosis with carbon dioxide laser. J Cutan Med Surg. 2012;16(5):372–4.

    PubMed  Google Scholar 

  70. Kakani RS, Goldstein AE, Meisher I, Hoffman C. Nodular amyloidosis: case report and literature review. J Cutan Med Surg. 2001;5(2):101–4. doi:10.1007/s102270000014.

    CAS  PubMed  Google Scholar 

  71. Ritchie SA, Beachkofsky T, Schreml S, et al. Primary localized cutaneous nodular amyloidosis of the feet: a case report and review of the literature. Cutis. 2014;93(2):89–94.

    PubMed  Google Scholar 

  72. Panchaprateep R, Tusgate S, Munavalli GS, Noppakun N. Fractional 1,550 nm ytterbium/erbium fiber laser in the treatment of lichen amyloidosis: clinical and histological study. Lasers Surg Med. 2015;47(3):222–30. doi:10.1002/lsm.22338.

    PubMed  Google Scholar 

  73. Barsky M, Buka RL. Pulsed dye laser for the treatment of macular amyloidosis: a case report. Cutis. 2014;93(4):189–92.

    PubMed  Google Scholar 

  74. Sawamura D, Sato-Matsumura KC, Shibaki A, et al. A case of lichen amyloidosis treated with pulsed dye laser. J Eur Acad Dermatol Venereol. 2005;19(2):262–3. doi:10.1111/j.1468-3083.2005.01038.x.

    CAS  PubMed  Google Scholar 

  75. Alster TS, Manaloto RM. Nodular amyloidosis treated with a pulsed dye laser. Dermatol Surg. 1999;25(2):133–5.

    CAS  PubMed  Google Scholar 

  76. Anitha B, Mysore V. Lichen amyloidosis: novel treatment with fractional ablative 2,940 nm erbium:YAG laser treatment. J Cutan Aesthet Surg. 2012;5(2):141–3. doi:10.4103/0974-2077.99459.

    CAS  PubMed  PubMed Central  Google Scholar 

  77. Ostovari N, Mohtasham N, Oadras MS, Malekzad F. 532-nm and 1064-nm Q-switched Nd:YAG laser therapy for reduction of pigmentation in macular amyloidosis patches. J Eur Acad Dermatol Venereol. 2008;22(4):442–6. doi:10.1111/j.1468-3083.2007.02473.x.

    CAS  PubMed  Google Scholar 

  78. Liu HT. Treatment of lichen amyloidosis (LA) and disseminated superficial porokeratosis (DSP) with frequency-doubled Q-switched Nd:YAG laser. Dermatol Surg. 2000;26(10):958–62.

    CAS  PubMed  Google Scholar 

  79. Alonso-Gonzalez J, Rodriguez-Granados MT, Toribio J. Satisfactory response to narrowband UV-B therapy in generalized lichen amyloidosis. Actas Dermsifiliogr. 2013;104(6):527–9. doi:10.1016/j.ad.2012.07.014.

    CAS  Google Scholar 

  80. Oiso N, Yudate T, Kawara S, Kawada A. Successful treatment of lichen amyloidosus associated with atopic dermatitis using a combination of narrowband ultraviolet B phototherapy, topical corticosteroids and an antihistamine. Clin Exp Dermatol. 2009;34(8):e833–6. doi:10.1111/j.1365-2230.2009.03574.x.

    CAS  PubMed  Google Scholar 

  81. Parsi K, Kossard S. Thermosensitive lichen amyloidosis. Int J Dermatol. 2004;43(12):925–8. doi:10.1111/j.1365-4632.2004.02273.x.

    PubMed  Google Scholar 

  82. Kalkan G, Markoc F, Bas Y. An alternative treatment model: the combination therapy of narrow band ultraviolet B phototherapy and tacrolimus ointment 0.1% in biphasic amyloidosis. J Pak Med Assoc. 2014;64(5):579–82.

    PubMed  Google Scholar 

  83. Hudson LD. Macular amyloidosis: treatment with ultraviolet B. Cutis. 1986;38(1):61–2.

    CAS  PubMed  Google Scholar 

  84. Grimmer J, Weiss T, Weber L, et al. Successful treatment of lichen amyloidosis with combined bath PUVA photochemotherapy and oral acitretin. Clin Exp Dermatol. 2007;32(1):39–42. doi:10.1111/j.1365-2230.2006.02244.x.

    CAS  PubMed  Google Scholar 

  85. Tran D, Kwok YK, Goh CL. A retrospective review of PUVA therapy at the National Skin Centre of Singapore. Photodermatol Photoimmunol Photomed. 2001;17(4):164–7.

    CAS  PubMed  Google Scholar 

  86. Soler-Carrillo J, Alsina-Gibert MM, Mascaro JM. Lichen amyloidosus universalis associated with long-term drug intake. Dermatology. 1997;195(3):286–8.

    CAS  PubMed  Google Scholar 

  87. Engin B, Tufekci O, Yazici A, Ozdemir M. The effect of transcutaneous electrical nerve stimulation in the treatment of lichen simplex: a prospective study. Clin Exp Dermatol. 2009;34(3):324–8. doi:10.1111/j.1365-2230.2008.03086.x.

    CAS  PubMed  Google Scholar 

  88. Yuksek J, Sezer E, Aksu M, Erkokmaz U. Transcutaneous electrical nerve stimulation for reduction of pruritus in macular amyloidosis and lichen simplex. J Dermatol. 2011;38(6):546–52. doi:10.1111/j.1346-8138.2010.01081.x.

    PubMed  Google Scholar 

  89. Yong AS, Murphy JG, Shah N. Nodular localized cutaneous amyloidosis in an immunosuppressed patient. Int J Dermatol. 2015;54(6):708–9. doi:10.1111/ijd.12140.

    PubMed  Google Scholar 

  90. Fujisawa T, Shu E, Ikeda T, Seishima M. Primary localized cutaneous nodular amyloidosis that appeared in a patient with severe atopic dermatitis. J Dermatol. 2012;39(3):312–3. doi:10.1111/j.1346-8138.2011.01247.x.

    PubMed  Google Scholar 

  91. Lien MH, Railan D, Nelson BR. The efficacy of dermabrasion in the treatment of nodular amyloidosis. J Am Acad Dermatol. 1997;36(2 Pt 2):315–6.

    CAS  PubMed  Google Scholar 

  92. Okazaki M, Hisatomi T, Sarukawa S. Aesthetic upper lip reconstruction with vermilion submucosal-pedicle cross-lip flap. J Craniofacial Surg. 2006;17(6):1259–62. doi:10.1097/01.scs.0000246737.99718.87.

    Google Scholar 

  93. Ueno M, Yamamoto T, Yamanaka M, Matsunaga T. Nodular amyloidosis in a patient with liver cirrhosis. Dermatol Online J. 2011;17(7):10.

    PubMed  Google Scholar 

  94. Vestey JP, Tidman MJ, McLaren KM. Primary nodular cutaneous amyloidosis: long-term follow-up and treatment. Clin Exp Dermatol. 1994;19(2):159–62.

    CAS  PubMed  Google Scholar 

  95. Aoki M, Kawana S. Lichen amyloidosis of the auricular concha: successful treatment with electrodesiccation. J Dermatol. 2009;36(2):116–7. doi:10.1111/j.1346-8138.2009.00603.x.

    PubMed  Google Scholar 

  96. Harahap M, Marwali MR. The treatment of lichen amyloidosis: a review and a new technique. Dermatol Surg. 1998;24(2):251–4.

    CAS  PubMed  Google Scholar 

  97. Savant SS. Therapeutic regional dermabrasion in papular lichen amyloidosis of shins. Indian J Dermatol Venereol Leprol. 1995;61(4):196–201.

    CAS  PubMed  Google Scholar 

  98. Mun KS, Pailoor J, Reddy SC. Primary localised deep cutaneous amyloidosis of the eyelid. Malays J Pathol. 2005;27(2):113–5.

    PubMed  Google Scholar 

  99. Santos-Briz A, Canueto J, Antunez P, et al. Primary cutaneous localized amyloid elastosis. Am J Dermatopathol. 2010;32(1):86–90. doi:10.1097/DAD.0b013e3181b1c62f.

    PubMed  Google Scholar 

  100. Sangen Y, Kawada A, Maeda A, et al. Primary localized cutaneous amyloidosis in association with papillary thyroid carcinoma. J Cutan Med Surg. 2002;6(4):332–4. doi:10.1007/s10227-001-0052-7.

    PubMed  Google Scholar 

  101. Schucht K, Schroder J, Siegmund H, et al. Nodular cutaneous amyloidosis at the temple. Case Rep Dermatol. 2016;8(2):193–6. doi:10.1159/000447234.

    PubMed  PubMed Central  Google Scholar 

  102. Haverkampf S, Evert K, Schroder J, Schreml S. Nodular cutaneous amyloidosis resembling a giant tumor. Case Rep Dermatol. 2016;8(1):22–5. doi:10.1159/000443950.

    PubMed  PubMed Central  Google Scholar 

  103. Wechalekar AD, Goodman HJ, Lachmann HJ, et al. Safety and efficacy of risk-adapted cyclophosphamide, thalidomide, and dexamethasone in systemic AL amyloidosis. Blood. 2007;109(2):457–64. doi:10.1182/blood-2006-07-035352.

    CAS  PubMed  Google Scholar 

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  1. Department of Dermatology, University Hospital Jena, Erfurter Straße 35, Jena, 07743, Germany

    Till Weidner, Tanja Illing & Peter Elsner

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  1. Till Weidner
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Correspondence to Till Weidner.

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T Weidner, T. Illing, and P. Elsner have no conflicts of interest directly relevant to the content of this article.

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Weidner, T., Illing, T. & Elsner, P. Primary Localized Cutaneous Amyloidosis: A Systematic Treatment Review. Am J Clin Dermatol 18, 629–642 (2017). https://doi.org/10.1007/s40257-017-0278-9

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