Abstract
With the investigation of the efficacy of laser therapy in primary localized amyloidosis(PLCA) only recently starting to materialize, we aimed to review the currently available studies of laser therapy in the management of the disease. We searched PubMed, Scopus, Embase, Web of Science, Cochrane, and ProQuest online databases with a specified search strategy, assessed the quality of each study, and then extracted the eligible data. Five RCTs(randomized controlled trials), one non-randomized controlled trial, three case series, and nine case reports(18 in total) were included. Overall, carbon dioxide (CO2), neodymium-doped:yttrium aluminum garnet (Nd:YAG), pulsed dye (PDL), Er (Erbium):YAG, and yttrium/erbium fiber were the studied lasers. One hundred fifty-five cases in total underwent laser therapy, with CO2 being the most frequent laser. Almost all studies demonstrated significantly desirable outcomes, while only mild and transient side effects were noted. Even though the studies’ results were significant, we noticed that implementing a consistent methodology and a standardized objective assessment method was missing. Therefore, we recommend that future studies be conducted with less heterogeneous data for a more definite conclusion.
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The dataset supporting the conclusions of this article (i.e., data extracted from included studies) is available upon request to the corresponding author, Mohammad Shafie'ei.
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All authors participated in designing the protocol. First, NA, MS, and ZA designed the study. MS, ZA, and MSS then did the literature search. NA, MS, ZA, and MSS selected the studies and extracted the relevant information, then assessed and confirmed by the senior authors. All authors then participated in synthesizing the data. MS and NA also wrote the first draft of the paper. NA, NS, and MA provided critical guidance on the analysis and overall direction of the study. All authors critically revised successive drafts of the paper and approved the final version.
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Ahramiyanpour, N., Akbari, Z., Sarasyabi, M.S. et al. The therapeutic role of lasers in primary localized cutaneous amyloidosis: a systematic review. Lasers Med Sci 37, 799–813 (2022). https://doi.org/10.1007/s10103-021-03429-4
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DOI: https://doi.org/10.1007/s10103-021-03429-4