Abstract
series of novel chalcone derivatives was designed and synthesized via a suitable synthetic strategy in good yields using commercially available 2-amino-4-nitrophenol as an initiator. The structures of the target compounds were confirmed by means of 1H NMR, 13C NMR and high-resolution mass spectrometry(HRMS). And the ability of the target compounds to inhibit influenza viruses was evaluated. These compounds showed moderate inhibitory activity against influenza A(H9N2 and H5N1) viruses. Within this series, compounds S14 and S15 with good potency(IC50=40.3―51.5 μmol/L) could be used as lead compounds in the future.
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Supported by the National High-tech R&D Program of China(No.2014AA020523), the National Natural Science Foundation of China(Nos.21302111, 81373282, 21172134) and the China Postdoctoral Science Foundation Funded Project (Nos.2013M540558, 2014T70654).
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Shi, F., Fang, H. & Xu, W. Design, synthesis and biological activity of novel chalcone derivatives as anti-influenza agents. Chem. Res. Chin. Univ. 32, 28–34 (2016). https://doi.org/10.1007/s40242-015-5356-z
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DOI: https://doi.org/10.1007/s40242-015-5356-z