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Sleep disordered breathing in hospitalized patients

  • Sleeping and Breathing (T Lee-Chiong, Section Editor)
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Abstract

Sleep is a ubiquitous phenomenon that is both adaptive and restorative. Obstructive sleep apnea, obesity–hypoventilation syndrome, primary central sleep apnea, and Cheyne–Stokes breathing/complex sleep apnea are the most common sleep-related breathing disorders encountered in the hospitalized population. Sleep disordered breathing (SDB) is commoner in hospitalized patients with obesity, congestive cardiac failure, COPD, and osteoarthritis. Various hospital and ICU-related factors contribute to disruption of sleep architecture and circadian rhythm. Sleep deprivation has been linked to higher incidence of delirium, prolonged hospitalization, and mortality during the hospital stay and long-term cognitive impairment. Persistent sleep deprivation also causes impairment in immune response. There is now a conclusive body of evidence linking SDB with higher prevalence of cardiovascular disease, stroke, diabetes, perioperative complications, and worse outcome. Hence, early recognition and treatment of SDB has become important for patients admitted in medical wards, critical care units, and post-surgical wards.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Roca J, Fuentes LJ, Marotta A, López-Ramón M-F, Castro C, Lupiáñez J, et al. The effects of sleep deprivation on the attentional functions and vigilance. Acta Psychol (Amst). 2012;140(2):164–76.

    Article  Google Scholar 

  2. Boivin DB, Czeisler CA, Dijk DJ, Duffy JF, Folkard S, Minors DS, et al. Complex interaction of the sleep-wake cycle and circadian phase modulates mood in healthy subjects. Arch Gen Psychiatry. 1997;54(2):145–52.

    Article  CAS  PubMed  Google Scholar 

  3. Surridge-David M, MacLean A, Coulter ME, Knowles JB. Mood change following an acute delay of sleep. Psychiatry Res. 1987;22(2):149–58.

    Article  CAS  PubMed  Google Scholar 

  4. Kawano H, Motoyama T, Yasue H, Hirai N, Waly HM, Kugiyama K, et al. Endothelial function fluctuates with diurnal variation in the frequency of ischemic episodes in patients with variant angina. J Am Coll Cardiol. 2002;40(2):266–70.

    Article  CAS  PubMed  Google Scholar 

  5. Gottlieb DJ, Redline S, Nieto FJ, Baldwin CM, Newman AB, Resnick HE, et al. Association of usual sleep duration with hypertension: the Sleep Heart Health Study. Sleep. 2006;29(8):1009–14.

    PubMed  Google Scholar 

  6. Bonsignore MR, Smirne S, Marrone O, Insalaco G, Salvaggio A, Bonsignore G. Myocardial ischemia during sleep. Sleep Med Rev. 1999;3(3):241–55.

    Article  CAS  PubMed  Google Scholar 

  7. Spiegel K, Tasali E, Penev P, Van Cauter E. Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med. 2004;141(11):846–50.

    Article  PubMed  Google Scholar 

  8. Taheri S, Lin L, Austin D, Young T, Mignot E. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med. 2004;1(3):e62.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Redwine L, Hauger RL, Gillin JC, Irwin M. Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans. J Clin Endocrinol Metab. 2000;85(10):3597–603.

    CAS  PubMed  Google Scholar 

  10. Heiser P, Dickhaus B, Schreiber W, Clement HW, Hasse C, Hennig J, et al. White blood cells and cortisol after sleep deprivation and recovery sleep in humans. Eur Arch Psychiatry Clin Neurosci. 2000;250(1):16–23.

    Article  CAS  PubMed  Google Scholar 

  11. Dinges DF, Douglas SD, Hamarman S, Zaugg L, Kapoor S. Sleep deprivation and human immune function. Adv Neuroimmunol. 1995;5(2):97–110.

    Article  CAS  PubMed  Google Scholar 

  12. Zhao H, Yin J-Y, Yang W-S, Qin Q, Li T-T, Shi Y, et al. Sleep duration and cancer risk: a systematic review and meta-analysis of prospective studies. Asian Pac J Cancer Prev APJCP. 2013;14(12):7509–15.

    Article  PubMed  Google Scholar 

  13. Kubo T, Ozasa K, Mikami K, Wakai K, Fujino Y, Watanabe Y, et al. Prospective cohort study of the risk of prostate cancer among rotating-shift workers: findings from the Japan collaborative cohort study. Am J Epidemiol. 2006;164(6):549–55.

    Article  PubMed  Google Scholar 

  14. Davis S, Mirick DK. Circadian disruption, shift work and the risk of cancer: a summary of the evidence and studies in Seattle. Cancer Causes Control CCC. 2006;17(4):539–45.

    Article  PubMed  Google Scholar 

  15. Schernhammer ES, Laden F, Speizer FE, Willett WC, Hunter DJ, Kawachi I, et al. Night-shift work and risk of colorectal cancer in the nurses’ health study. J Natl Cancer Inst. 2003;95(11):825–8.

    Article  PubMed  Google Scholar 

  16. Jennum P, Riha RL. Epidemiology of sleep apnoea/hypopnoea syndrome and sleep-disordered breathing. Eur Respir J. 2009;33(4):907–14.

    Article  CAS  PubMed  Google Scholar 

  17. Bixler EO, Vgontzas AN, Lin H-M, Calhoun SL, Vela-Bueno A, Kales A. Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression. J ClinEndocrinolMetab. 2005;90(8):4510–5.

    Article  CAS  Google Scholar 

  18. Durán J, Esnaola S, Rubio R, Iztueta A. Obstructive sleep apnea-hypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr. Am J RespirCrit Care Med. 2001;163(3 Pt 1):685–9.

    Article  Google Scholar 

  19. Seneviratne U, Puvanendran K. Excessive daytime sleepiness in obstructive sleep apnea: prevalence, severity, and predictors. Sleep Med. 2004;5(4):339–43.

    Article  PubMed  Google Scholar 

  20. Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013;177(9):1006–14. This study highlights the rising prevalence of sleep disordered breathing in the generalpopulation.

    Article  PubMed  PubMed Central  Google Scholar 

  21. United States Department of Health and Human Services.National Center for Health Statistics. National Hospital Discharge Survey, 2004: Version 1 [Internet]. 2006 May [cited 2015 Sep 4]. Available from: http://www.icpsr.umich.edu/NACDA/studies/04442/version/1

  22. Spurr K, Morrison DL, Graven MA, Webber A, Gilbert RW. Analysis of hospital discharge data to characterize obstructive sleep apnea and its management in adult patients hospitalized in Canada: 2006 to 2007. Can RespirJ CanThorac Soc. 2010;17(5):213–8.

    Google Scholar 

  23. Nowbar S, Burkart KM, Gonzales R, Fedorowicz A, Gozansky WS, Gaudio JC, et al. Obesity-associated hypoventilation in hospitalized patients: prevalence, effects, and outcome. Am J Med. 2004;116(1):1–7.

    Article  PubMed  Google Scholar 

  24. Berg G, Delaive K, Manfreda J, Walld R, Kryger MH. The use of health-care resources in obesity-hypoventilation syndrome. Chest. 2001;120(2):377–83.

    Article  CAS  PubMed  Google Scholar 

  25. Sanders MH, Newman AB, Haggerty CL, Redline S, Lebowitz M, Samet J, et al. Sleep and sleep-disordered breathing in adults with predominantly mild obstructive airway disease. Am J RespirCrit Care Med. 2003;167(1):7–14.

    Article  Google Scholar 

  26. Bednarek M, Plywaczewski R, Jonczak L, Zielinski J. There is no relationship between chronic obstructive pulmonary disease and obstructive sleep apnea syndrome: a population study. RespirInt Rev Thorac Dis. 2005;72(2):142–9.

    Google Scholar 

  27. López-Acevedo MN, Torres-Palacios A, Elena Ocasio-Tascón M, Campos-Santiago Z, Rodríguez-Cintrón W. Overlap syndrome: an indication for sleep studies? A pilot study. Sleep Breath Schlaf Atm. 2009;13(4):409–13.

    Article  Google Scholar 

  28. Turcani P, Skrickova J, Pavlik T, Janousova E, Orban M. The prevalence of obstructive sleep apnea in patients hospitalized for COPD exacerbation. Czechoslov: Biomed Pap Med FacUnivPalacky Olomouc; 2014.

    Google Scholar 

  29. Goring K, Collop N. Sleep disordered breathing in hospitalized patients. J Clin Sleep Med JCSM Off Publ Am Acad Sleep Med. 2008;4(2):105–10.

    Google Scholar 

  30. Ely EW, Shintani A, Truman B, Speroff T, Gordon SM, Harrell FE, et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA. 2004;291(14):1753–62.

    Article  CAS  PubMed  Google Scholar 

  31. Elliott R, McKinley S, Cistulli P, Fien M. Characterisation of sleep in intensive care using 24-hour polysomnography: an observational study. Crit Care Lond Engl. 2013;17(2):R46. This study has objectively measured the sleep quality and quantity and the factors affecting it in the ICU setting.

    Article  Google Scholar 

  32. Pisani MA, Kong SYJ, Kasl SV, Murphy TE, Araujo KLB, Van Ness PH. Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J RespirCrit Care Med. 2009;180(11):1092–7.

    Article  Google Scholar 

  33. Girard TD, Jackson JC, Pandharipande PP, Pun BT, Thompson JL, Shintani AK, et al. Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med. 2010;38(7):1513–20.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Thomason JWW, Shintani A, Peterson JF, Pun BT, Jackson JC, Ely EW. Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients. Crit Care Lond Engl. 2005;9(4):R375–81.

    Article  Google Scholar 

  35. Bryant PA, Trinder J, Curtis N. Sick and tired: does sleep have a vital role in the immune system. Nat Rev Immunol. 2004;4(6):457–67.

    Article  CAS  PubMed  Google Scholar 

  36. Born J, Lange T, Hansen K, Mölle M, Fehm HL. Effects of sleep and circadian rhythm on human circulating immune cells. J Immunol Baltim Md. 1997;158(9):4454–64.

    CAS  Google Scholar 

  37. Spiegel K, Sheridan JF, Van Cauter E. Effect of sleep deprivation on response to immunization. JAMA. 2002;288(12):1471–2.

    Article  PubMed  Google Scholar 

  38. Kahn-Greene ET, Killgore DB, Kamimori GH, Balkin TJ, Killgore WDS. The effects of sleep deprivation on symptoms of psychopathology in healthy adults. Sleep Med. 2007;8(3):215–21.

    Article  PubMed  Google Scholar 

  39. Babkoff H, Sing HC, Thorne DR, Genser SG, Hegge FW. Perceptual distortions and hallucinations reported during the course of sleep deprivation. Percept Mot Skills. 1989;68(3 Pt 1):787–98.

    Article  CAS  PubMed  Google Scholar 

  40. Watson PL, Ceriana P, Fanfulla F. Delirium: is sleep important? Best Pract Res ClinAnaesthesiol. 2012;26(3):355–66. This article links sleep deprivation to delirium in the hospital which is a marker of poor outcome.

    Article  Google Scholar 

  41. Chen HI, Tang YR. Sleep loss impairs inspiratory muscle endurance. Am Rev Respir Dis. 1989;140(4):907–9.

    Article  CAS  PubMed  Google Scholar 

  42. White DP, Douglas NJ, Pickett CK, Zwillich CW, Weil JV. Sleep deprivation and the control of ventilation. Am Rev Respir Dis. 1983;128(6):984–6.

    CAS  PubMed  Google Scholar 

  43. Kaneko Y, Floras JS, Usui K, Plante J, Tkacova R, Kubo T, et al. Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea. N Engl J Med. 2003;348(13):1233–41.

    Article  PubMed  Google Scholar 

  44. Redfield MM, Jacobsen SJ, Burnett JC, Mahoney DW, Bailey KR, Rodeheffer RJ. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA. 2003;289(2):194–202.

    Article  PubMed  Google Scholar 

  45. Arnulf I, Merino-Andreu M, Perrier A, Birolleau S, Similowski T, Derenne J-P. Obstructive sleep apnea and venous thromboembolism. JAMA. 2002;287(20):2655–6.

    Article  PubMed  Google Scholar 

  46. Hilton BA. Quantity and quality of patients’ sleep and sleep-disturbing factors in a respiratory intensive care unit. J AdvNurs. 1976;1(6):453–68.

    CAS  Google Scholar 

  47. Aurell J, Elmqvist D. Sleep in the surgical intensive care unit: continuous polygraphic recording of sleep in nine patients receiving postoperative care. Br Med J (Clin Res Ed). 1985;290(6474):1029–32.

    Article  CAS  Google Scholar 

  48. Freedman NS, Gazendam J, Levan L, Pack AI, Schwab RJ. Abnormal sleep/wake cycles and the effect of environmental noise on sleep disruption in the intensive care unit. Am J RespirCrit Care Med. 2001;163(2):451–7.

    Article  CAS  Google Scholar 

  49. Cooper S, Oborne J, Newton S, Harrison V, Thompson Coon J, Lewis S, et al. Effect of two breathing exercises (Buteyko and pranayama) in asthma: a randomised controlled trial. Thorax. 2003;58(8):674–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Watson PL, Pandharipande P, Gehlbach BK, Thompson JL, Shintani AK, Dittus BS, et al. Atypical sleep in ventilated patients: empirical electroencephalography findings and the path toward revised ICU sleep scoring criteria. Crit Care Med. 2013;41(8):1958–67.

    Article  PubMed  Google Scholar 

  51. Scoring sleep in critically ill patients. Limitations in standard methodology and need for revised criteria. Crit Care Med. 2006;34(12):A83.

    Google Scholar 

  52. Gehlbach BK, Chapotot F, Leproult R, et al. Temporal disorganization of circadian rhythmicity and sleep-wake regulation in mechanically ventilated patients receiving continuous intravenous sedation. Sleep. 2012;35:1105–14.

    PubMed  PubMed Central  Google Scholar 

  53. Mundigler G, Delle-Karth G, Koreny M, et al. Impaired circadian rhythm of melatonin secretion in sedated critically ill patients with severe sepsis. Crit Care Med. 2002;30:536–40.

    Article  CAS  PubMed  Google Scholar 

  54. Hetzenecker A, Buchner S, Greimel T, Satzl A, Luchner A, Debl K, et al. Cardiac workload in patients with sleep-disordered breathing early after acute myocardial infarction. Chest. 2013;143(5):1294–301.

    Article  PubMed  Google Scholar 

  55. Thurnheer R. Obstructive sleep apnea and cardiovascular disease—time to act! Swiss Med Wkly. 2007;137(15–16):217–22.

    PubMed  Google Scholar 

  56. Dyken ME, Somers VK, Yamada T, Ren ZY, Zimmerman MB. Investigating the relationship between stroke and obstructive sleep apnea. Stroke J Cereb Circ. 1996;27(3):401–7.

    Article  CAS  Google Scholar 

  57. Schober A-K, Neurath MF, Harsch IA. Prevalence of sleep apnoea in diabetic patients. ClinRespir J. 2011;5(3):165–72.

    Google Scholar 

  58. Punjabi NM, Caffo BS, Goodwin JL, Gottlieb DJ, Newman AB, O’Connor GT, et al. Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med. 2009;6(8):e1000132.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Young T, Finn L, Peppard PE, Szklo-Coxe M, Austin D, Nieto FJ, et al. Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep. 2008;31(8):1071–8.

    PubMed  PubMed Central  Google Scholar 

  60. Marin JM, Carrizo SJ, Vicente E, Agusti AGN. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet Lond Engl. 2005;365(9464):1046–53.

    Article  Google Scholar 

  61. Shah N, Redline S, Yaggi HK, Wu R, Zhao CG, Ostfeld R, et al. Obstructive sleep apnea and acute myocardial infarction severity: ischemic preconditioning? Sleep Breath Schlaf Atm. 2013;17(2):819–26.

    Article  Google Scholar 

  62. Floras JS. Sleep apnea and cardiovascular risk. J Cardiol. 2014;63(1):3–8. This article describes the cardiovascular risks associated with sleep disordered breathing.

    Article  PubMed  Google Scholar 

  63. Patel D, Mohanty P, Di Biase L, Shaheen M, Lewis WR, Quan K, et al. Safety and efficacy of pulmonary vein antral isolation in patients with obstructive sleep apnea: the impact of continuous positive airway pressure. CircArrhythmElectrophysiol. 2010;3(5):445–51.

    Google Scholar 

  64. Mehra R, Benjamin EJ, Shahar E, Gottlieb DJ, Nawabit R, Kirchner HL, et al. Association of nocturnal arrhythmias with sleep-disordered breathing: The Sleep Heart Health Study. Am J RespirCrit Care Med. 2006;173(8):910–6.

    Article  Google Scholar 

  65. Kanagala R, Murali NS, Friedman PA, Ammash NM, Gersh BJ, Ballman KV, et al. Obstructive sleep apnea and the recurrence of atrial fibrillation. Circulation. 2003;107(20):2589–94.

    PubMed  Google Scholar 

  66. Kasai T, Bradley TD. Obstructive sleep apnea and heart failure: pathophysiologic and therapeutic implications. J Am CollCardiol. 2011;57(2):119–27.

    Article  Google Scholar 

  67. Shepard JW, Pevernagie DA, Stanson AW, Daniels BK, Sheedy PF. Effects of changes in central venous pressure on upper airway size in patients with obstructive sleep apnea. Am J RespirCrit Care Med. 1996;153(1):250–4.

    Article  Google Scholar 

  68. Yumino D, Redolfi S, Ruttanaumpawan P, Su M-C, Smith S, Newton GE, et al. Nocturnal rostral fluid shift: a unifying concept for the pathogenesis of obstructive and central sleep apnea in men with heart failure. Circulation. 2010;121(14):1598–605.

    Article  PubMed  Google Scholar 

  69. Kasai T, Arcand J, Allard JP, Mak S, Azevedo ER, Newton GE, et al. Relationship between sodium intake and sleep apnea in patients with heart failure. J Am CollCardiol. 2011;58(19):1970–4.

    Article  CAS  Google Scholar 

  70. Yumino D, Bradley TD. Central sleep apnea and Cheyne-Stokes respiration. Proc Am Thorac Soc. 2008;5(2):226–36.

    Article  PubMed  Google Scholar 

  71. Kaye DM, Mansfield D, Aggarwal A, Naughton MT, Esler MD. Acute effects of continuous positive airway pressure on cardiac sympathetic tone in congestive heart failure. Circulation. 2001;103(19):2336–8.

    Article  CAS  PubMed  Google Scholar 

  72. Tkacova R, Rankin F, Fitzgerald FS, Floras JS, Bradley TD. Effects of continuous positive airway pressure on obstructive sleep apnea and left ventricular afterload in patients with heart failure. Circulation. 1998;98(21):2269–75.

    Article  CAS  PubMed  Google Scholar 

  73. Naughton MT, Rahman MA, Hara K, Floras JS, Bradley TD. Effect of continuous positive airway pressure on intrathoracic and left ventricular transmural pressures in patients with congestive heart failure. Circulation. 1995;91(6):1725–31.

    Article  CAS  PubMed  Google Scholar 

  74. Khayat RN, Abraham WT, Patt B, Pu M, Jarjoura D. In-hospital treatment of obstructive sleep apnea during decompensation of heart failure. Chest. 2009;136(4):991–7.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Staniforth AD, Kinnear WJ, Starling R, Hetmanski DJ, Cowley AJ. Effect of oxygen on sleep quality, cognitive function and sympathetic activity in patients with chronic heart failure and Cheyne–Stokes respiration. Eur Heart J. 1998;19(6):922–8.

    Article  CAS  PubMed  Google Scholar 

  76. Franklin KA, Eriksson P, Sahlin C, Lundgren R. Reversal of central sleep apnea with oxygen. Chest. 1997;111(1):163–9.

    Article  CAS  PubMed  Google Scholar 

  77. Doherty LS, Kiely JL, Swan V, McNicholas WT. Long-term effects of nasal continuous positive airway pressure therapy on cardiovascular outcomes in sleep apnea syndrome. Chest. 2005;127(6):2076–84.

    Article  PubMed  Google Scholar 

  78. Haentjens P, Van Meerhaeghe A, Moscariello A, De Weerdt S, Poppe K, Dupont A, et al. The impact of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea syndrome: evidence from a meta-analysis of placebo-controlled randomized trials. Arch Intern Med. 2007;167(8):757–64.

    Article  PubMed  Google Scholar 

  79. Alajmi M, Mulgrew AT, Fox J, Davidson W, Schulzer M, Mak E, et al. Impact of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea hypopnea: a meta-analysis of randomized controlled trials. Lung. 2007;185(2):67–72.

    Article  CAS  PubMed  Google Scholar 

  80. Wang H, Parker JD, Newton GE, Floras JS, Mak S, Chiu K-L, et al. Influence of obstructive sleep apnea on mortality in patients with heart failure. J Am CollCardiol. 2007;49(15):1625–31.

    Article  Google Scholar 

  81. Malone S, Liu PP, Holloway R, Rutherford R, Xie A, Bradley TD. Obstructive sleep apnoea in patients with dilated cardiomyopathy: effects of continuous positive airway pressure. Lancet Lond Engl. 1991;338(8781):1480–4.

    Article  CAS  Google Scholar 

  82. Mansfield DR, Gollogly NC, Kaye DM, Richardson M, Bergin P, Naughton MT. Controlled trial of continuous positive airway pressure in obstructive sleep apnea and heart failure. Am J RespirCrit Care Med. 2004;169(3):361–6.

    Article  Google Scholar 

  83. Smith LA, Vennelle M, Gardner RS, McDonagh TA, Denvir MA, Douglas NJ, et al. Auto-titrating continuous positive airway pressure therapy in patients with chronic heart failure and obstructive sleep apnoea: a randomized placebo-controlled trial. Eur Heart J. 2007;28(10):1221–7.

    Article  PubMed  Google Scholar 

  84. Bradley TD, Logan AG, Kimoff RJ, Sériès F, Morrison D, Ferguson K, et al. Continuous positive airway pressure for central sleep apnea and heart failure. N Engl J Med. 2005;353(19):2025–33.

    Article  CAS  PubMed  Google Scholar 

  85. Philippe C, Stoïca-Herman M, Drouot X, Raffestin B, Escourrou P, Hittinger L, et al. Compliance with and effectiveness of adaptive servoventilation versus continuous positive airway pressure in the treatment of Cheyne–Stokes respiration in heart failure over a six month period. Heart Br Card Soc. 2006;92(3):337–42.

    Article  CAS  Google Scholar 

  86. Pepperell JCT, Maskell NA, Jones DR, Langford-Wiley BA, Crosthwaite N, Stradling JR, et al. A randomized controlled trial of adaptive ventilation for Cheyne–Stokes breathing in heart failure. Am J RespirCrit Care Med. 2003;168(9):1109–14.

    Article  Google Scholar 

  87. Cowie MR, Woehrle H, Wegscheider K, et al. Adaptive servo-ventilation for central sleep apnea in systolic heart failure. N Engl J Med. 2015;373(12):1095–105. This is the most recent randomised trial which has cast doubt about the usefulness of adaptive servo ventilation for the treatment of CSA specially in those with systolic dysfunction.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. McArdle N, Riha RL, Vennelle M, Coleman EL, Dennis MS, Warlow CP, et al. Sleep-disordered breathing as a risk factor for cerebrovascular disease: a case–control study in patients with transient ischemic attacks. Stroke J Cereb Circ. 2003;34(12):2916–21.

    Article  Google Scholar 

  89. Sahlin C, Sandberg O, Gustafson Y, Bucht G, Carlberg B, Stenlund H, et al. Obstructive sleep apnea is a risk factor for death in patients with stroke: a 10-year follow-up. Arch Intern Med. 2008;168(3):297–301.

    Article  PubMed  Google Scholar 

  90. Harbison J, Gibson GJ, Birchall D, Zammit-Maempel I, Ford GA. White matter disease and sleep-disordered breathing after acute stroke. Neurology. 2003;61(7):959–63.

    Article  CAS  PubMed  Google Scholar 

  91. Martínez-García MA, Galiano-Blancart R, Román-Sánchez P, Soler-Cataluña J-J, Cabero-Salt L, Salcedo-Maiques E. Continuous positive airway pressure treatment in sleep apnea prevents new vascular events after ischemic stroke. Chest. 2005;128(4):2123–9.

    Article  PubMed  Google Scholar 

  92. Fletcher EC, Donner CF, Midgren B, Zielinski J, Levi-Valensi P, Braghiroli A, et al. Survival in COPD patients with a daytime PaO2 greater than 60 mmHg with and without nocturnal oxyhemoglobin desaturation. Chest. 1992;101(3):649–55.

    Article  CAS  PubMed  Google Scholar 

  93. Mokhlesi B, Hovda MD, Vekhter B, Arora VM, Chung F, Meltzer DO. Sleep-disordered breathing and postoperative outcomes after elective surgery: analysis of the nationwide inpatient sample. Chest. 2013;144(3):903–14.

    Article  PubMed  PubMed Central  Google Scholar 

  94. Kaw R, Chung F, Pasupuleti V, Mehta J, Gay PC, Hernandez AV. Meta-analysis of the association between obstructive sleep apnoea and postoperative outcome. Br J Anaesth. 2012;109(6):897–906. This study highlights the importance of evaluation and treatment of SBD in patients undergoing emergency or elective surgery as there is increased risk of complications.

    Article  CAS  PubMed  Google Scholar 

  95. Memtsoudis S, Liu SS, Ma Y, Chiu YL, Walz JM, Gaber-Baylis LK, et al. Perioperative pulmonary outcomes in patients with sleep apnea after noncardiac surgery. AnesthAnalg. 2011;112(1):113–21.

    Google Scholar 

  96. Gross JB, Bachenberg KL, Benumof JL, Caplan RA, Connis RT, Coté CJ, et al. Practice guidelines for the perioperative management of patients with obstructive sleep apnea: a report by the American Society of Anesthesiologists Task Force on Perioperative Management of patients with obstructive sleep apnea. Anesthesiology. 2006;104(5):1081–93. quiz 1117–8.

    Article  PubMed  Google Scholar 

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Correspondence to Anant Mohan.

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Vipin Malik, Ashesh Dhungana, and Anant Mohan declare that they have no conflict of interest.

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Mohan, A., Dhungana, A. & Malik, V. Sleep disordered breathing in hospitalized patients. Curr Pulmonol Rep 5, 116–122 (2016). https://doi.org/10.1007/s13665-016-0143-y

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