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Relationship between serum pro- and anti-inflammatory cytokine and growth factor concentrations with the age and gender adjusted prevalence of diabetes and pre-diabetes

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

The main goal of the present study is to compare the serum pro- and anti-inflammatory cytokines and growth factor profile (IL-1α, IL-1β, IL-2, IL-6, IL-8, IFN-γ, MCP-1, TNF-α, IL-10, IL-4, VEGF, and EGF) in individuals with diabetes or pre-diabetes and control subjects matched for age and gender. This study included 270 normal control subjects, 41 pre-diabetics, and 104 diabetic subjects. Demographic and anthropometric characteristics and serum biochemistry parameters, smoking status, and blood pressure were determined. Serum cytokine and growth factor measurements were performed using a multiplex biochip array based method. After removing the effects of confounders such as age, sex, smoking, BMI, serum triglyceride and cholesterol, hypertension, and treatment with anti-diabetic drugs, serum IL-4 (p = 0.015), IL-1α (p = 0.031), and VEGF (p = 0.012) were significantly associated with the presence of diabetes mellitus. The presence of pre-diabetes was positively associated with serum IL-4 (p < 0.001), and IL-1α (p = 0.026). We have found a positive association between serum IL-1α, and IL-4, and a negative association of serum VEGF with the presence of diabetes, or pre-diabetes.

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Acknowledgements

This study was conducted as a M.Sc. degree thesis with financial support provided by the Research Council at the Mashhad University of Medical Sciences, Mashhad, Iran. The authors would like to express their sincerest thanks to the patients and their family members who volunteered to participate in this study.

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Authors and Affiliations

  1. Medical Genetics Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Elahe Mahdipour

  2. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Elahe Mahdipour, Shiva Ganjali & Sara Shoeibi

  3. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Maryam Azizian & Mohsen Nematy

  4. Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran

    Seyed Reza Mirhafez

  5. Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Seyed Reza Mirhafez & Majid Ghayour Mobarhan

  6. Department of Biostatistics, Mashhad University of Medical Sciences, Mashhad, Iran

    Habibollah Esmaily

  7. Metabolic Syndrom Research Center, Mashhad University of Medical Sciences, Mashhad, 99199, Iran

    Habibollah Esmaily & Majid Ghayour Mobarhan

  8. Division of Medical Education, Brighton and Sussex Medical School, Falmer, Brighton, Sussex, BN1 9PH, UK

    Gordon AA Ferns

Authors
  1. Elahe Mahdipour
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  2. Maryam Azizian
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  3. Seyed Reza Mirhafez
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  4. Shiva Ganjali
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  5. Sara Shoeibi
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  6. Mohsen Nematy
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  7. Habibollah Esmaily
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  8. Gordon AA Ferns
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  9. Majid Ghayour Mobarhan
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Corresponding author

Correspondence to Majid Ghayour Mobarhan.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Mashhad University of Medical Sciences research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Mahdipour, E., Azizian, M., Mirhafez, S.R. et al. Relationship between serum pro- and anti-inflammatory cytokine and growth factor concentrations with the age and gender adjusted prevalence of diabetes and pre-diabetes. Int J Diabetes Dev Ctries 37, 313–319 (2017). https://doi.org/10.1007/s13410-016-0538-x

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  • DOI: https://doi.org/10.1007/s13410-016-0538-x

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