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The correlation between adiposity and adiponectin, tumor necrosis factor α, interleukin-6 and high sensitivity C-reactive protein levels. Is adipocyte size associated with inflammation in adults?

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Abstract

Objective: Hypertrophic obesity correlates with metabolic complications of obesity. We evaluated adipocyte volume and its relationship with tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), adiponectin and high sensitivity C-reactive protein (hs-CRP) levels. Subjects and methods: Patients were divided into 4 groups; lean healthy controls [body mass index (BMI): 24.2±1.4 kg/m2], non-diabetic obese patients (30.2±2.9), obese (30.1 ±3.2) and non-obese (22.2±1.5) Type 2 diabetic patients. TNF-α, hs-CRP, adiponectin and IL-6 levels were measured preoperatively and sc fat specimens were obtained during operation. Semi-thin sections were stained with toluidine-blue and evaluated by light microscopy. Fat volumes were calculated by Goldrick’s formulation. Results: Mean adipocyte volumes were higher in obese diabetic patients than in other groups (p<0.0001). Mean TNF-α, hs-CRP and IL-6 levels were higher in obese diabetic patients than in control subjects, obese non-diabetic and non-obese diabetic patients (p<0.0001, p<0.02 and p<0.01. respectively). Mean TNF-α levels of non-diabetic obese patients were higher than the control group (p<0.05). Mean IL-6 levels of diabetic and non-diabetic obese patients were higher than control subjects (p<0.02 and p<0.0001, respectively). Mean adiponectin levels of control subjects were higher than non-diabetic obese, non-obese diabetic and obese-diabetic subjects (p<0.0001). Mean adiponectin levels of obese diabetic patients were lower than non-diabetic obese subjects (p<0.008). Mean hs-CRP levels were higher in diabetic patients whether they were obese or not. There was a positive correlation between adipocyte size and TNF-α (p<0.01), IL-6 (p<0.03) and hs-CRP levels (p<0.004), and negative correlation between adipocyte size, adiponectin levels (p<0.0001). Conclusions: TNF-α, IL-6 and hs-CRP levels were positively, adiponectin negatively correlated with adipocyte size. Therefore, adiposity may be an inflammatory condition.

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Authors and Affiliations

  1. Department of Endocrinology, Dicle University School of Medicine, 21280, Diyarbakir, Turkey

    M. Bahceci MD, D. Gokalp, A. Tuzcu & S. Arikan

  2. Department of Histology and Embryology, Dicle University School of Medicine, Diyarbakir, Turkey

    S. Bahceci

  3. Department of Microbiology, Dicle University School of Medicine, Diyarbakir, Turkey

    S. Atmaca

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  1. M. Bahceci MD
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  2. D. Gokalp
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  3. S. Bahceci
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  6. S. Arikan
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Correspondence to M. Bahceci MD.

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Bahceci, M., Gokalp, D., Bahceci, S. et al. The correlation between adiposity and adiponectin, tumor necrosis factor α, interleukin-6 and high sensitivity C-reactive protein levels. Is adipocyte size associated with inflammation in adults?. J Endocrinol Invest 30, 210–214 (2007). https://doi.org/10.1007/BF03347427

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