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Role of the rs9939609 gene variant of FTO on cardiovascular risk factors and adipokines levels in naive patients with diabetes mellitus type 2

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Abstract

One of the genetic variants (rs9939609) of FTO gene is related with obesity and type 2 diabetes mellitus. The aim of the present study was to analyze the relationship of the rs9939609 FTO gene polymorphism to body weight, insulin resistance, cardiovascular risk factors and serum adipokine levels in patients with diabetes. 123 naïve patients with diabetes mellitus type 2 were analyzed in a cross sectional design. Body weight, blood pressure, fast blood glucose, c-reactive protein (CRP), insulin, HbA1c, insulin resistance (homeostasis model assessment, HOMA-R), total cholesterol, HDL-cholesterol, HDL-cholesterol, triglycerides blood and adipocytokines levels were measured. Forty one patients (14 males/27 females) (33.3 %) had the genotype TT (wild type group), 51 (11 males/40 females) (41.5 %) TA and 31 (9 males/22 females) (25.2 %) AA (mutant type group). No association between the FTO variant and anthropometric parameters or blood pressure was found. Wild type group had higher HOMA-R (1.3 units:CI95% 0.51–5.8), insulin (3.3 mUI/L:CI95% 0.31–13.4) and triglyceride (12.6 mg/dl: CI95% 3.90–46.1) levels than mutant allelic group (TA and AA). Adipocytokines levels were similar in both genotype groups. The FTO gene polymorphism, rs9939609, was found to be associated with HOMA-R, insulin and triglyceride levels in naïve diabetic patients with TT variant.

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Conflict of interest

There is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

Funding

This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

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Authors and Affiliations

  1. Center of Investigation of Endocrinology and Clinical Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain

    Daniel Antonio de Luis, Rocío Aller, Rosa Conde, Olatz Izaola, Beatriz de la Fuente, Manuel Gonzalez Sagrado, David Primo & Marta Ruiz Mambrilla

  2. Center of Investigation of Endocrinology and Clinical Nutrition, Medicine School, Valladolid University, C/Los perales 16 Simancas, 47130, Valladolid, Spain

    Daniel Antonio de Luis

Authors
  1. Daniel Antonio de Luis
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  2. Rocío Aller
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  3. Rosa Conde
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  4. Olatz Izaola
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  5. Beatriz de la Fuente
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  6. Manuel Gonzalez Sagrado
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  8. Marta Ruiz Mambrilla
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Correspondence to Daniel Antonio de Luis.

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Author contribution statement

D. A de Luis realized design and statistical of the study.

M González Sagrado realized biochemical studies.

R. Aller realized nutritional evaluation.

O. Izaola realized nutritional evaluation.

B de la Fuente realized nutritional evaluation.

D Primo realized biochemical studies.

R Conde realized biochemical studies.

Marta Ruiz Mambrilla realized design and statistical of the study.

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de Luis, D.A., Aller, R., Conde, R. et al. Role of the rs9939609 gene variant of FTO on cardiovascular risk factors and adipokines levels in naive patients with diabetes mellitus type 2. Int J Diabetes Dev Ctries 33, 202–206 (2013). https://doi.org/10.1007/s13410-013-0151-1

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