, Volume 23, Issue 6, pp 1011-1014,
Open Access This content is freely available online to anyone, anywhere at any time.
Date: 03 Apr 2012

How Ubiquitin Unfolds after Transfer into the Gas Phase


The structural evolution of ubiquitin after transfer into the gas phase was studied by electron capture dissociation. Site-specific fragment yields show that ubiquitin’s solution fold is overall unstable in the gas phase, but unfolding caused by loss of solvent is slowest in regions stabilized by salt bridges.