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GALNT7, a target of miR-494, participates in the oncogenesis of nasopharyngeal carcinoma

  • Original Article
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Tumor Biology

Abstract

GalNAc-transferase-7 (GALNT7) is essential for the regulation of cell proliferation and has been implicated in tumorigenesis. However, the role of GALNT7 in the development and progression of nasopharyngeal carcinoma (NPC) remains unclear. Our previous study showed that GALNT7 was a putative target of miR-494, which was confirmed by luciferase reporter assay. In the present study, we demonstrated that in vitro knockdown of GALNT7 significantly inhibited the proliferation, colony formation, migration, and invasion of NPC-derived cells. In vivo tumorigenicity assay showed that miR-494 and GALNT7-small interfering RNA (siRNA) reduced tumor growth in nude mice. Taken together, our results provided new evidence for an oncogenic role of GALNT7 in NPC.

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Acknowledgments

This research was supported by the Science and Technology Development Fund Project of Shenzhen (No. JCYJ20120827150357364, CXZZ20140416144209739, JCYJ20130329110752142, KQCX2012080314585099 and JCYJ20130402114702127) and the Medical Research Project of the Health and Family Planning Commission of Shenzhen (No. 201302005).

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    Authors and Affiliations

    1. Department of Otolaryngological, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong, China

      Guo-Hui Nie, Liang Luo, Hong-Fang Duan, Xiao-Qing Li, Mei-Jun Yin & Zhao Li

    2. Guangzhou Medical University, Guangzhou, 510000, Guangdong, China

      Liang Luo & Zhao Li

    3. Biomedical Research Institute, Shenzhen Peking University—The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, Guangdong, China

      Wei Zhang

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    1. Guo-Hui Nie
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    Correspondence to Guo-Hui Nie or Wei Zhang.

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    Guo-Hui Nie, Liang Luo and Hong-Fang Duan contributed equally to this work.

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    Nie, GH., Luo, L., Duan, HF. et al. GALNT7, a target of miR-494, participates in the oncogenesis of nasopharyngeal carcinoma. Tumor Biol. 37, 4559–4567 (2016). https://doi.org/10.1007/s13277-015-4281-6

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    • DOI: https://doi.org/10.1007/s13277-015-4281-6

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