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Chronic atrophic gastritis in association with hair mercury level

  • Research Article
  • Published:
Tumor Biology

Abstract

The objective of this study was to explore hair mercury level in association with chronic atrophic gastritis, a precancerous stage of gastric cancer (GC), and thus provide a brand new angle of view on the timely intervention of precancerous stage of GC. We recruited 149 healthy volunteers as controls and 152 patients suffering from chronic gastritis as cases. The controls denied upper gastrointestinal discomforts, and the cases were diagnosed as chronic superficial gastritis (n = 68) or chronic atrophic gastritis (n = 84). We utilized Mercury Automated Analyzer (NIC MA-3000) to detect hair mercury level of both healthy controls and cases of chronic gastritis. The statistic of measurement data was expressed as mean ± standard deviation, which was analyzed using Levene variance equality test and t test. Pearson correlation analysis was employed to determine associated factors affecting hair mercury levels, and multiple stepwise regression analysis was performed to deduce regression equations. Statistical significance is considered if p value is less than 0.05. The overall hair mercury level was 0.908949 ± 0.8844490 ng/g [mean ± standard deviation (SD)] in gastritis cases and 0.460198 ± 0.2712187 ng/g (mean ± SD) in healthy controls; the former level was significantly higher than the latter one (p = 0.000 < 0.01). The hair mercury level in chronic atrophic gastritis subgroup was 1.155220 ± 0.9470246 ng/g (mean ± SD) and that in chronic superficial gastritis subgroup was 0.604732 ± 0.6942509 ng/g (mean ± SD); the former level was significantly higher than the latter level (p < 0.01). The hair mercury level in chronic superficial gastritis cases was significantly higher than that in healthy controls (p < 0.05). The hair mercury level in chronic atrophic gastritis cases was significantly higher than that in healthy controls (p < 0.01). Stratified analysis indicated that the hair mercury level in healthy controls with eating seafood was significantly higher than that in healthy controls without eating seafood (p < 0.01) and that the hair mercury level in chronic atrophic gastritis cases was significantly higher than that in chronic superficial gastritis cases (p < 0.01). Pearson correlation analysis indicated that eating seafood was most correlated with hair mercury level and positively correlated in the healthy controls and that the severity of gastritis was most correlated with hair mercury level and positively correlated in the gastritis cases. Multiple stepwise regression analysis indicated that the regression equation of hair mercury level in controls could be expressed as 0.262 multiplied the value of eating seafood plus 0.434, the model that was statistically significant (p < 0.01). Multiple stepwise regression analysis also indicated that the regression equation of hair mercury level in gastritis cases could be expressed as 0.305 multiplied the severity of gastritis, the model that was also statistically significant (p < 0.01). The graphs of regression standardized residual for both controls and cases conformed to normal distribution. The main positively correlated factor affecting the hair mercury level is eating seafood in healthy people whereas the predominant positively correlated factor affecting the hair mercury level is the severity of gastritis in chronic gastritis patients. That is to say, the severity of chronic gastritis is positively correlated with the level of hair mercury. The incessantly increased level of hair mercury possibly reflects the development of gastritis from normal stomach to superficial gastritis and to atrophic gastritis. The detection of hair mercury is potentially a means to predict the severity of chronic gastritis and possibly to insinuate the environmental mercury threat to human health in terms of gastritis or even carcinogenesis.

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Authors and Affiliations

  1. Shanghai High School, Shanghai, 200231, China

    Zeyun Xue

  2. Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Diseases, 145 Middle Shandong Road, Shanghai, 200001, China

    Huiping Xue

  3. Pharmacy Department, Shanghai Research Academy of Environmental Science, Shanghai, 200025, China

    Jianlan Jiang & Xiaoyun Huang

  4. Division of Nutrition, School of Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China

    Bing Lin

  5. Life Science Division, Shanghai High School, Shanghai, 200231, China

    Si Zeng

  6. Department of Information, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, 200001, China

    Jianfu An

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  1. Zeyun Xue
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  2. Huiping Xue
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  7. Jianfu An
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Correspondence to Huiping Xue.

Additional information

Zeyun Xue, Huiping Xue, Jianlan Jiang, Bing Lin, and Si Zeng contributed equally to this work.

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Supplemental Figure 1

The residual analysis and its histogram check in controls. (PDF 102 kb)

Supplemental Figure 2

Standard P-P diagram of regression standardized residuals in controls (Normal probability plot). (PDF 110 kb)

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Xue, Z., Xue, H., Jiang, J. et al. Chronic atrophic gastritis in association with hair mercury level. Tumor Biol. 35, 11391–11398 (2014). https://doi.org/10.1007/s13277-014-2475-y

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  • DOI: https://doi.org/10.1007/s13277-014-2475-y

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