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Mercury Transfer During Pregnancy and Breastfeeding: Hair Mercury Concentrations as Biomarker

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Abstract

Hair mercury (HHg) concentration is a biomarker of exposure that is widely used to assess environmental contamination by fish methylmercury and neurodevelopment in children. In the Rio Madeira basin (Brazilian Amazon), total HHg concentrations in 649 mother–infant pairs were measured at birth (prenatal exposure) and after 6 months of exclusive breastfeeding; these mother–infant pairs were from high fish-eating communities (urban, n = 232; rural, n = 35; and Riverine, n = 262) and low fish-eating tin-miner settlers (n = 120). Differences in kinetics were seen between Hg exposure from fish consumption and environmental exposure to a tin-ore mining environment. Overall maternal HHg concentrations (at childbirth and after 6 months of lactation) were higher than those of infant HHg. However, the relative change in HHg after 6 months of lactation showed that mothers decreased HHg while infants increased HHg. The relative change showed a consistently higher increase for girls than boys with a statistical significance only in high fish-eating mothers. The correlation coefficients between maternal and newborn hair were high and statistically significant for mothers living in urban (r = 0.66, p < 0.001), rural (r = 0.89, p < 0.001), and Riverine (r = 0.89, p < 0.001) communities not for tin miner settlers (r = 0.07, p = 0.427). After 6 months of exclusive breastfeeding, correlation coefficients showed high correlation coefficients and statistical significance for all groups (urban, r = 0.73, p < 0.001; rural, r = 0.88, p < 0.001; Riverine, r = 0.91, p < 0.001) except for Tin miners (r = −0.07, p = 0.428). A linear model analysis was used to assess the longitudinal associations of maternal total HHg and total HHg at birth (0 days) and 6 months of age in exclusively breastfed infants. Regression analysis significantly predicted HHg in newborn from maternal HHg for high fish-eating maternal-infant pairs. Conclusion: The concentration of mercury accumulated in newborn tissues (in utero and during breastfeeding) relevant to both, maternal sources and infant exposure, can be reliably assessed from maternal hair.

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References

  1. ATSDR (2013) Agency for Toxic Substances and Disease Registry Division of Toxicology and Human Health Sciences. Atlanta, GA 30333, March

  2. Sakamoto M, Chan HM, Domingo JL, Kawakami S, Murata K (2012) Mercury and docosahexaenoic acid levels in maternal and cord blood in relation to segmental maternal hair mercury concentrations at parturition. Environ Int 44:112–117

    Article  PubMed  CAS  Google Scholar 

  3. Yasuda H, Yoshida K, Yasuda Y, Tsutsui T (2012) Two age-related accumulation profiles of toxic metals. Curr Aging Sci 5:105–111

    Article  PubMed  CAS  Google Scholar 

  4. Grandjean P, Budtz-Jørgensen E (2010) An ignored risk factor in toxicology: the total imprecision of exposure assessment. Pure Appl Chem 82:383–391

    Article  PubMed  CAS  Google Scholar 

  5. Vieira SM, de Almeida R, Holanda IB, Mussy MH, Galvão RC, Crispim PT, Dórea JG, Bastos WR (2013) Total and methyl-mercury in hair and milk of mothers living in the city of Porto Velho and in villages along the Rio Madeira, Amazon, Brazil. Int J Hyg Environ Health, doi:S1438-4639(12)00147-2

  6. Sakamoto M, Chan HM, Domingo JL, Kubota M, Murata K (2012) Changes in body burden of mercury, lead, arsenic, cadmium and selenium in infants during early lactation in comparison with placental transfer. Ecotoxicol Environ Saf 84:179–184

    Article  PubMed  CAS  Google Scholar 

  7. Barbosa AC, Silva SR, Dórea JG (1998) Concentration of mercury in hair of indigenous mothers and infants from the Amazon basin. Arch Environ Contam Toxicol 34:100–105

    Article  PubMed  CAS  Google Scholar 

  8. Marques RC, Dórea JG, Fonseca MF, Bastos WR, Malm O (2007) Hair mercury in breast-fed infants exposed to thimerosal-preserved vaccines. Eur J Pediatr 166:935–941

    Article  PubMed  CAS  Google Scholar 

  9. Razagui IB, Haswell SJ (2001) Mercury and selenium concentrations in maternal and neonatal scalp hair: relationship to amalgam-based dental treatment received during pregnancy. Biol Trace Elem Res 81:1–19

    Article  PubMed  CAS  Google Scholar 

  10. Lindow SW, Knight R, Batty J, Haswell SJ (2003) Maternal and neonatal hair mercury concentrations: the effect of dental amalgam. BJOG 110:287–291

    Article  PubMed  CAS  Google Scholar 

  11. Mohan S, Tiller M, van der Voet G, Kanhai H (2005) Mercury exposure of mothers and newborns in Surinam: a pilot study. Clin Toxicol (Phila) 43:101–104

    CAS  Google Scholar 

  12. Weiss B (2011) Same sex, no sex, and unaware sex in neurotoxicology. Neurotoxicology 32:509–517

    Article  PubMed  Google Scholar 

  13. Mergler D (2012) Neurotoxic exposures and effects: gender and sex matter! Hänninen Lecture 2011. Neurotoxicology 33:644–651

    Article  PubMed  CAS  Google Scholar 

  14. Marques RC, Dórea JG, McManus C, Leão RS, Brandão KG, Marques RC, Vieira IH, Guimarães JR, Malm O (2011) Hydroelectric reservoir inundation (Rio Madeira Basin, Amazon) and changes in traditional lifestyle: impact on growth and neurodevelopment of pre-school children. Public Health Nutr 14:661–669

    Article  PubMed  Google Scholar 

  15. Marques RC, Dórea JG, Leão RS, Dos Santos VG, Bueno L, Marques RC, Brandão KG, Palermo EF, Guimarães JR (2012) Role of methylmercury exposure (from fish consumption) on growth and neurodevelopment of children under 5 years of age living in a transitioning (tin-mining) area of the western Amazon, Brazil. Arch Environ Contam Toxicol 62:341–150

    Article  PubMed  CAS  Google Scholar 

  16. Marques RC, Bernardi JVE, Dórea JG, Brandão KG, Bueno L, Leão RS, Malm O (2013) Fish consumption during pregnancy, mercury transfer, and birth weight along the Madeira River basin in Amazonia. Int J Environ Res Pub Health 10:2150–2163

    Article  CAS  Google Scholar 

  17. Barghi M, Behrooz RD, Esmaili-Sari A, Ghasempouri SM (2012) Mercury exposure assessment in Iranian pregnant women’s hair with respect to diet, amalgam filling, and lactation. Biol Trace Elem Res 148:292–301

    Article  PubMed  CAS  Google Scholar 

  18. Okati N, Sari AE, Ghasempouri SM (2012) Hair mercury concentrations of lactating mothers and breastfed infants in Iran (fish consumption and mercury exposure). Biol Trace Elem Res 149:155–162

    Article  PubMed  CAS  Google Scholar 

  19. Greenwood MR, Clarkson TW, Doherty RA, Gates AH, Amin-Zaki L, Elhassani S, Majeed MA (1978) Environ Res 16:48

    Article  PubMed  CAS  Google Scholar 

  20. Grandjean P, Jørgensen PJ, Weihe P (1994) Human milk as a source of methylmercury exposure in infants. Environ Health Perspect 102:74–77

    Article  PubMed  CAS  Google Scholar 

  21. Gareri J, Koren G (2010) Prenatal hair development: implications for drug exposure determination. Forensic Sci Int 196:27–31

    Article  PubMed  CAS  Google Scholar 

  22. Cernichiari E, Myers GJ, Ballatori N, Zareba G, Vyas J, Clarkson T (2007) The biological monitoring of prenatal exposure to methylmercury. Neurotoxicology 28:1015–1022

    Article  PubMed  CAS  Google Scholar 

  23. Al-Saleh I, Shinwari N, El-Doush I, Billedo G, Al-Amodi M, Khogali F (2004) Comparison of mercury levels in various tissues of albino and pigmented mice treated with two different brands of mercury skin-lightening creams. Biometals 17:167–175

    Article  PubMed  CAS  Google Scholar 

  24. Dórea JG, Pereira SE (1983) The influence of hair color on the concentration of zinc and copper in boys’ hair. J Nutr 113:2375–2381

    PubMed  Google Scholar 

  25. Kauf E, Wiesner W, Niese S, Plenert W (1984) Zinc, copper, manganese and gold content of the hair of infants. Acta Paediatr Hung 25(3):299–307

    Google Scholar 

  26. Dórea JG, Horner MR, Campanate ML (1985) Lacteal zinc and copper in relation to volume, total ash and energy during the first three months of lactation of Brazilian women. Acta Paediatr Scand 74:891–896

    Article  PubMed  Google Scholar 

  27. Dórea JG, Brito M, Araujo MO (1987) Concentration of copper and zinc in liver of fetuses and infants. J Am Coll Nutr 6:491–495

    PubMed  Google Scholar 

  28. Donangelo CM, Trugo NM, Dórea JG, Araújo MO (1993) Liver reserves of iron, copper, and vitamin B12 in Brazilian fetuses and infants of different socioeconomic status. Nutrition 9:430–432

    PubMed  CAS  Google Scholar 

  29. Shimomura S, Kimura A, Nakagawa H, Takao M (1980) Mercury levels in human hair and sex factors. Environ Res 22:22–30

    Article  PubMed  CAS  Google Scholar 

  30. Airey D (1983) Total mercury concentrations in human hair from 13 countries in relation to fish consumption and location. Sci Total Environ 31:157–180

    Article  PubMed  CAS  Google Scholar 

  31. Wakisaka I, Yanagihashi T, Sato M, Nakano A (1990) Factors contributing to the difference of hair mercury concentrations between the sexes. Nihon Eiseigaku Zasshi 45:654–664

    Article  PubMed  CAS  Google Scholar 

  32. Grandjean P, Neilsen GD, Jorgensen PG, Horder M (1992) Reference intervals for trace elements in blood: significance of risk factors. Scand J Clin Lab Invest 52:321–337

    Article  PubMed  CAS  Google Scholar 

  33. Harada M, Nakanishi J, Konuma S, Ohno K, Kimura T, Yamaguchi H, Tsuruta K, Kizaki T, Ookawara T, Ohno (1998) The present mercury contents of scalp hair and clinical symptoms in inhabitants of the Minamata area. Environ Res 77:160–164

    Article  PubMed  CAS  Google Scholar 

  34. Barbosa AC, Jardim W, Dórea JG, Fosberg B, Souza J (2001) Hair mercury speciation as a function of gender, age, and body mass index in inhabitants of the Negro River basin, Amazon, Brazil. Arch Environ Contam Toxicol 40:439–444

    Article  PubMed  CAS  Google Scholar 

  35. Lebel J, Mergler D, Branches F, Lucotte M, Amorim M, Larribe F, Dolbec (1998) Neurotoxic effects of low-level methylmercury contamination in the Amazonian Basin. Environ Res 79:20–32

    Article  PubMed  CAS  Google Scholar 

  36. Fujimura M, Matsuyama A, Harvard JP, Bourdineaud JP, Nakamura K (2012) Mercury contamination in humans in Upper Maroni, French Guiana between 2004 and 2009. Bull Environ Contam Toxicol 88:135–139

    Article  PubMed  CAS  Google Scholar 

  37. Barbosa AC, Dórea JG (1998) Indices of mercury contamination during breast feeding in the Amazon Basin. Environ Toxicol Pharmacol 6:71–79

    Article  PubMed  CAS  Google Scholar 

  38. Dórea JG (2007) Exposure to mercury during the first six months via human milk and vaccines: modifying risk factors. Am J Perinatol 24:387–400

    Article  PubMed  Google Scholar 

  39. Park HJ, Kim SA, Moon JS, Yang W, Son BS (2008) Mercury level in hair of primary school children in Korea and China. Mol Cell Toxicol 4:235–245

    Google Scholar 

  40. Redwood L, Bernard S, Brown D (2001) Predicted mercury concentrations in hair from infant immunizations: cause for concern. Neurotoxicology 22:691–697

    Article  PubMed  CAS  Google Scholar 

  41. Dórea JG, Wimer W, Marques RC, Shade C (2011) Automated speciation of mercury in the hair of breastfed infants exposed to ethylmercury from thimerosal-containing vaccines. Biol Trace Elem Res 140(3):262–71

    Article  PubMed  Google Scholar 

  42. Dórea JG, Bezerra VL, Fajon V, Horvat M (2011) Speciation of methyl- and ethyl-mercury in hair of breastfed infants acutely exposed to thimerosal-containing vaccines. Clin Chim Acta 412:1563–566

    Article  PubMed  Google Scholar 

  43. Grandjean P, Weihe P, Nielsen JB (1994) Methylmercury: significance of intrauterine and postnatal exposures. Clin Chem 40(7 Pt 2):1395–1400

    PubMed  CAS  Google Scholar 

  44. Boischio AA, Henshel DS (2000) Linear regression models of methyl mercury exposure during prenatal and early postnatal life among riverside people along the upper Madeira River, Amazon. Environ Res 83:150–161

    Article  PubMed  CAS  Google Scholar 

  45. Savabieasfahani M, Hoseiny M, Goodarzi S (2012) Toxic and essential trace metals in first baby haircuts and mother hair from Imam Hossein Hospital Tehran, Iran. Bull Environ Contam Toxicol 88:140–144

    Article  PubMed  CAS  Google Scholar 

  46. Razagui IB, Haswell SJ (1997) The determination of mercury and selenium in maternal and neonatal scalp hair by inductively coupled plasma-mass spectrometry. J Anal Toxicol 21:149–153

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Universidade Federal do Rio de Janeiro, Campus Macaé, Rio de Janeiro, 27930-560, RJ, Brazil

    Rejane C. Marques

  2. University of Brasília, Brasília, 0919-970, DF, Brazil

    José V. E. Bernardi & José G. Dórea

  3. Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, CEP 21941-902, Rio de Janeiro, RJ, Brazil

    Renata S. Leão & Olaf Malm

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  1. Rejane C. Marques
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  2. José V. E. Bernardi
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  3. José G. Dórea
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  4. Renata S. Leão
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  5. Olaf Malm
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Correspondence to José G. Dórea.

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Marques, R.C., Bernardi, J.V.E., Dórea, J.G. et al. Mercury Transfer During Pregnancy and Breastfeeding: Hair Mercury Concentrations as Biomarker. Biol Trace Elem Res 154, 326–332 (2013). https://doi.org/10.1007/s12011-013-9743-3

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  • DOI: https://doi.org/10.1007/s12011-013-9743-3

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