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Herbal drug loaded poly(D,L-lactide-co-glycolide) ultrafine fibers: Interaction with pathogenic bacteria

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Abstract

This study investigated for the first time the antimicrobial effect of methanolic extract of Grewia mollis Juss (mGM) against Staphylococcus aureus KCCM 11256 (Gram positive) and Escherichia coli KCCM 11234 (Gram negative). The minimum inhibitory concentration (MIC) values for each bacterial strain were recorded in a liquid medium. In addition, ultrafine poly(D,L-lactide-co-glycolide) (PLGA) fiber mats containing a methanolic crude extract (7.5 wt%) of Grewia mollis (mGM) were fabricated from the neat PLGA solution by electrospinning. The PLGA ultrafine fiber mat containing mGM were characterized by SEM, FE-SEM, Bio-TEM, TGA, and EDX analyses. Our findings indicate that the incorporation of mGM in the polymer media affected both the morphology and size of the mGM-loaded PLGA ultrafine fibers (UFs). SEM-EDX results confirmed well oriented ultrafine fibers with good incorporation of mGM. Results of the structure characterization indicated that the incorporated mGM interacted strongly with the PLGA matrix and the mechanical properties were effectively improved. Moreover, mGM loaded PLGA ultrafine fiber mats were able to inhibit the growth of the bacterial strains, which indicate that mGM blended PLGA fibers could be used as a potential effective antimicrobial agent for many biomedical applications including wound dressing.

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Authors and Affiliations

  1. Department of Pharmacognosy, College of pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    Hanan M. Al-Youssef & Musarat Amina

  2. Center for Healthcare Technology Development, Chonbuk National University, Jeonbuk, 561-756, Korea

    Touseef Amna & Hak Yong Kim

  3. Department of Organic Materials and Fiber Engineering, Chonbuk National University, Jeonbuk, 561-756, Korea

    Shamshi Hassan, Jin Won Jeong, Ki-Taek Nam & Hak Yong Kim

Authors
  1. Hanan M. Al-Youssef
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  2. Musarat Amina
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  3. Shamshi Hassan
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  4. Touseef Amna
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  5. Jin Won Jeong
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  6. Ki-Taek Nam
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  7. Hak Yong Kim
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Correspondence to Touseef Amna or Hak Yong Kim.

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Al-Youssef, H.M., Amina, M., Hassan, S. et al. Herbal drug loaded poly(D,L-lactide-co-glycolide) ultrafine fibers: Interaction with pathogenic bacteria. Macromol. Res. 21, 589–598 (2013). https://doi.org/10.1007/s13233-013-1062-1

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  • DOI: https://doi.org/10.1007/s13233-013-1062-1

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