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Buccal Versus Vaginal Misoprostol Administration for the Induction of First and Second Trimester Abortions

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Abstract

Objectives

To compare the effectiveness, side effects, and patient satisfaction of buccal versus vaginal misoprostol administration in first and second trimester induced abortions.

Methods

In first trimester, women received oral mifepristone followed by misoprostol either by buccal or vaginal route. In second trimester, women received oral mifepristone followed by repeated doses of misoprostol either by buccal or vaginal route. A comparative analysis using SPSS was done.

Results

In first trimester, success rate of medical abortion was 96 % in buccal group and 88 % in vaginal group. Nausea was the most common adverse effect which was similar in both groups. In second trimester, success rate was 96 % in buccal group and 80 % in vaginal group. A statistically higher incidence of nausea was noticed in buccal group. Patient satisfaction level was almost similar in both the groups in both trimesters.

Conclusions

Buccal and vaginal routes of misoprostol administration have similar efficacy and patient satisfaction level for first and second trimester induced abortions. Hence, buccal route may serve as an alternative to vaginal misoprostol.

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Compliance with ethical standards

The study was conducted among the patients selected from out patient department of Government Medical College and Hospital, Sector 32, Chandigarh and requesting for medical abortions. A written and informed consent was taken from all. The interventions involved in the present study are routinely practiced in Obstetrics and Gynecology and are safe. The patients were given the right to opt out of the study at any time they want. The defined guidelines of Central Ethics Committee for Biomedical Research on Human subjects by ICMR and guidelines as per Helsinki Declaration were strictly adherent in the present project.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Government Multispeciality Hospital Sector 16, Chandigarh, India

    Geetika Garg Medical Officer

  2. Department of Obstetrics and Gynecology, Government Medical College and Hospital, Sector 32, Chandigarh, India

    Navneet Takkar Associate Professor & Alka Sehgal Associate Professor

Authors
  1. Geetika Garg Medical Officer
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  2. Navneet Takkar Associate Professor
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  3. Alka Sehgal Associate Professor
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Corresponding author

Correspondence to Geetika Garg Medical Officer.

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Garg, G., Takkar, N. & Sehgal, A. Buccal Versus Vaginal Misoprostol Administration for the Induction of First and Second Trimester Abortions. J Obstet Gynecol India 65, 111–116 (2015). https://doi.org/10.1007/s13224-014-0605-5

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  • DOI: https://doi.org/10.1007/s13224-014-0605-5

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