Original Article

3 Biotech

, 1:173

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Nanocrystalline hydroxyapatite and zinc-doped hydroxyapatite as carrier material for controlled delivery of ciprofloxacin

  • G. Devanand VenkatasubbuAffiliated withCrystal Growth Centre, Anna University Email author 
  • , S. RamasamyAffiliated withCrystal Growth Centre, Anna University
  • , V. RamakrishnanAffiliated withDepartment of Laser Studies, School of Physics, Madurai Kamaraj University
  • , J. KumarAffiliated withCrystal Growth Centre, Anna University


In bone disorders infections are common. The concentration of majority of antibiotics is very low in the bone tissue. A high local dose can be obtained from the ciprofloxacin-loaded hydroxyapatite nanoparticles. The present study is aimed at developing the use of hydroxyapatite and zinc-doped hydroxyapatite nanoparticles as a carrier for ciprofloxacin drug delivery system. The ciprofloxacin-loaded hydroxyapatite and zinc-doped hydroxyapatite have a good antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus. Hydroxyapatite and zinc-doped hydroxyapatite were prepared and characterized using X-ray diffraction, Transmission electron microscopy and inductively coupled plasma optical emission spectrometry. They were loaded with ciprofloxacin using optimized drug loading parameters. Drug loading, in vitro drug release and antimicrobial activity were analyzed. The influence of zinc on the controlled release of ciprofloxacin was analyzed. The results show that the presence of zinc increases the drug release percentage and that the drug was released in a controlled manner.


Biomaterials Ciprofloxacin Controlled release Drug delivery Hydroxyapatite Pseudomonas aeruginosa Staphylococcus aureus