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Micronutrients-incorporated calcium phosphate particles with protective effect on osteoporotic bone tissue

  • Published:
The journal of nutrition, health & aging

Abstract

Background

Supplementation of individual micronutrient is inadequate for maintaining bone function because single micronutrient can not contribute significantly a positive remodeling balance.

Objective

We developed the highly integrated, stably dietary multi-micronutrients with good bioavailability and low adverse effect on the improvement of bone consolidation in osteoporosis.

Methods

The trace element-codoped calcium phosphate (teCaP) particles were prepared in the modified body fluid and carefully evaluated. Rats, aged 3 months, were ovariectomized and when 6 month intervened with the conditioned, low, moderate, and high teCaP diets.

Results

The teCaP particles showed highly dissolvable in stomach juice-mimicing acidic solutions. Three months after intervention, the body weight increase showed remarkable differences among the low teCaP diet (∼52 g), moderate teCaP diet (∼34 g) and high teCaP diet (∼23 g) group. In particular, the intake of moderate teCaP greatly improved the retention of trace elements in femural bone for better protection against the skeletal weakening, and resulted in a significant increase of bone mineral density (104.06%) in comparison with the conventional high calcium plus vitamin D3 diet (Control group).

Conclusions

These investigations improve our understanding of micronutrient retention on bone consolidation in osteoporotic bone tissue, and also provide new mild wet-chemical approach to prepare potent nutritionally effective edible complements to synergistically relieve bone degeneration and prevent osteoporosis.

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Authors and Affiliations

  1. Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou, 310029, China

    X. Chen, X. Yang, Z. Li & Zongru Gou

  2. Rui’an People’s Hospital & the 3rd Hospital Affiliated to Wenzhou Medical College, Ruian, 325200, China

    L. Zhang, X. Sun, M. Lin & G. Yang

  3. Dr. Bio-nanomaterials and Regenerative Medicine Research Division, Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou, 310029, China

    Zongru Gou

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  1. X. Chen
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  2. L. Zhang
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  4. Z. Li
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Correspondence to Zongru Gou.

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Chen, X., Zhang, L., Yang, X. et al. Micronutrients-incorporated calcium phosphate particles with protective effect on osteoporotic bone tissue. J Nutr Health Aging 17, 426–433 (2013). https://doi.org/10.1007/s12603-013-0006-y

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  • DOI: https://doi.org/10.1007/s12603-013-0006-y

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