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Solid-State Nanopore for Molecular Detection

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Abstract

Solid-state nanopore (SSNP) or synthetic nanopore using semiconductor materials have established themselves as a single molecule bio-detection platform. Although biological nanopore with fixed dimension has been successfully utilized for many sensing applications, SSNP has unique characteristics of distinctly potent geometries and relaxation of modification. The most common method of molecular detection is to measure the temporal variations of the ionic current in the pore. In this review, the principles of the SSNP and the improvement of device performance for the molecular detection platform are discussed elaborately. Moreover, different experimental aspects of the SSNP are discussed in detail. For instance, the enhancement of spatial resolution, modification of temporal resolution with the difficulties of its analyte-detection, as well as reduction of the electrical noise for the improvement of device sensing functionalities, all are addressed in designated chapters for better conception. In addition, the typical and updated applications of SSNP including DNA, protein and virus are briefly discussed. Finally, this article offers the context needed to comprehend current research trends and promote molecular sensing through synthetic nanopores.

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Funding

This research was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean government (Ministry of Science and ICT) (NRF-2020R1A2C300488512 and NRF-2020R1A4A200272812).

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Authors and Affiliations

  1. Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea

    Muhammad Refatul Haq, Bong Jae Lee & Jungchul Lee

  2. Center for Extreme Thermal Physics and Manufacturing, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea

    Muhammad Refatul Haq, Bong Jae Lee & Jungchul Lee

Authors
  1. Muhammad Refatul Haq
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  2. Bong Jae Lee
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  3. Jungchul Lee
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Correspondence to Jungchul Lee.

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Haq, M.R., Lee, B.J. & Lee, J. Solid-State Nanopore for Molecular Detection. Int. J. Precis. Eng. Manuf. 22, 2001–2026 (2021). https://doi.org/10.1007/s12541-021-00590-2

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  • DOI: https://doi.org/10.1007/s12541-021-00590-2

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