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Microwave-Assisted ZrSiO2 Catalysed Synthesis, Characterization and Computational Study of Novel Spiro[Indole-Thiazolidines] Derivatives as Anti-tubercular Agents

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Abstract

In the current investigation, we prepared a series of novel spiro[indole-thiazolidines] derivatives (5a–5h) from 5-substituted isatin derivatives and thioglycolic acid (TGA) with ZrSiO2 as an efficient catalyst under microwave irradiation. The significant merits of this protocol have some significant merits such as simplicity in operation, simple, efficient workup, good practical yields of product and the employment of recyclable catalyst. All the new synthesized scaffold has been well characterized by various spectroscopic methods and elemental analysis. All the spiro scaffolds were subjected to in vitro anti-mycobacterial activity against the Mycobacterium tuberculosis (H37Rv) strain. We have carried out molecular docking study of our synthesized compounds. We also calculated theoretically ADME–Tox parameters for synthesized compounds.

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Acknowledgements

The authors (MNB and MAB) are very thankful to UGC-BSR for financial support and other institutes for given that amenities for our research work.

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Authors and Affiliations

  1. Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, 380009, Gujarat, India

    Mayuri A. Borad, Manoj N. Bhoi, Sanjay K. Rathwa, Mahesh S. Vasava & Hitesh D. Patel

  2. Department of Bioinformatics, Applied Botany Centre (ABC), School of Sciences, Gujarat University, Ahmedabad, 380009, Gujarat, India

    Chirag N. Patel & Himanshu A. Pandya

  3. Department of Life Sciences, School of Sciences, Gujarat University, Ahmedabad, 380009, Gujarat, India

    Edwin. A. Pithawala

  4. Department of Bioinformatics, Christ College, Rajkot, 360 005, Gujarat, India

    John J. Georrge

Authors
  1. Mayuri A. Borad
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  2. Manoj N. Bhoi
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  3. Sanjay K. Rathwa
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  4. Mahesh S. Vasava
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  5. Hitesh D. Patel
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  6. Chirag N. Patel
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  7. Himanshu A. Pandya
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  8. Edwin. A. Pithawala
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Correspondence to Mayuri A. Borad.

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Borad, M.A., Bhoi, M.N., Rathwa, S.K. et al. Microwave-Assisted ZrSiO2 Catalysed Synthesis, Characterization and Computational Study of Novel Spiro[Indole-Thiazolidines] Derivatives as Anti-tubercular Agents. Interdiscip Sci Comput Life Sci 10, 411–418 (2018). https://doi.org/10.1007/s12539-016-0195-2

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  • DOI: https://doi.org/10.1007/s12539-016-0195-2

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