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Collagenous colitis appeared after 6-year administration of lansoprazole

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Abstract

Collagenous colitis (CC) is one of the causes of undefined watery diarrhea, which is histologically accompanied by thickening of the subepithelial collagen layer. CC associated with lansoprazole normally occurs within several weeks after initial administration, but no case presenting after long-term administration of lansoprazole has yet been reported. A 77-year-old male with 6-year history of administration of lansoprazole complained of watery diarrhea and weight loss. Colonoscopy revealed disappearance of vascular networks and red spots in the sigmoid colon. Biopsy specimen showed erosion and collagen bands thickened, so the patient was diagnosed as CC. After lansoprazole discontinuation, the watery diarrhea disappeared and histological abnormalities improved.

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Authors and Affiliations

  1. Department of Internal Medicine, Municipal Nakashibetsu Hospital, Nakashibetsu, Japan

    Koji Sawada, Kentaro Itabashi, Yasuyuki Suzuki & Koji Kubo

  2. Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, 2-1 Midorigaoka-higashi, Asahikawa, Hokkaido, 078-8510, Japan

    Mikihiro Fujiya, Toshie Nata, Nobuhiro Ueno, Yuhei Inaba, Kentaro Moriichi, Kotaro Okamoto, Katsuya Ikuta, Hiroki Tanabe, Yusuke Mizukami & Yutaka Kohgo

  3. GLab Pathology Center Co., Ltd., Sapporo, Japan

    Yoshitake Takagi

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  1. Koji Sawada
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Correspondence to Mikihiro Fujiya.

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Sawada, K., Fujiya, M., Itabashi, K. et al. Collagenous colitis appeared after 6-year administration of lansoprazole. Clin J Gastroenterol 3, 18–21 (2010). https://doi.org/10.1007/s12328-009-0126-4

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  • DOI: https://doi.org/10.1007/s12328-009-0126-4

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