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Microscopic colitides: a single center experience in Mexico

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Abstract

Background/aim

Microscopic colitis is characterized by chronic diarrhea and specific microscopic changes in a macroscopically normal colonic mucosa. In this paper, we report the clinical and histological features of a group of Mexican patients with microscopic colitis.

Materials and methods

Patients were identified from 10 years of data in the pathology database of our institution. A pathologist reassessed all biopsy material. We included only patients who met strict histopathological criteria. Clinical data were obtained from medical records.

Results

Microscopic colitis was diagnosed in 26 cases. The female/male ratio was 1.8:1. The median age at diagnosis was 56.5 ± 15.7 (range, 26–85) years. The most frequent symptoms were diarrhea in all, weight loss in 22 (84%), and abdominal pain in 18 (69%) patients. Sixteen (61%) patients reported associated diseases; autoimmune thyroid disorders were the most common. Drug-induced microscopic colitis was suspected in 12 (46%) patients. More than 80% of the treated patients improved or had clinical remission.

Conclusion

Microscopic colitis is an uncommon colonic disease at our institution, representing less than 1% of the final diagnoses in mucosal colonic biopsies. It is the largest case series of microscopic colitis in the Mexican population.

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References

  1. Pardi DS, Smyrk TC, Tremaine WJ, Sandborn WJ (2002) Microscopic colitis: a review. Am J Gastroenterol 97:794–802

    Article  PubMed  Google Scholar 

  2. Robert ME (2004) Microscopic colitis: pathologic considerations, changing dogma. J Clin Gastroenterol 38:S18–S26

    Article  PubMed  Google Scholar 

  3. Fernandez BF, Salas A, Forne M, Esteve M, Espinos J, Viverm JM (1999) Incidence of collagenous and lymphocytic colitis: A 5-year population-based study. Am J Gastroenterol 94(2):418–423

    Google Scholar 

  4. Lizardi-Cervera J, Moran-Villota S, Hinojo-Rivas E, Reynoso-Mendoza R, Correa-Rovelo JM, Pichardo-Bahena R, Uribe M (2002) Microscopic colitis. Rev Gastroenterol Mex 67:47–52

    PubMed  Google Scholar 

  5. Garg PK, Singh J, Dhali GK, Mathur M, Sharma MP (1996) Microscopic colitis is a cause of large bowel diarrhea in Northern India. J Clin Gastroenterol 22:11–15

    Article  PubMed  CAS  Google Scholar 

  6. Barta Z, Mekkel G, Csipo I, Toth L, Szakall S, Szabo GG, Bako G, Szegedi G, Zeher M (2005) Microscopic colitis: a retrospective study of clinical presentation in 53 patients. World J Gastroenterol 11:1351–1355

    PubMed  Google Scholar 

  7. Olesen M, Eriksson S, Bohr J, Järnerot G, Tysk C (2004) Microscopic colitis: a common diarrhoeal disease. An epidemiological study in Orebro, Sweden, 1993–1998. Gut 53:346–350

    Article  PubMed  CAS  Google Scholar 

  8. Olesen M, Ericksson S, Bohr J, Järnerot G, Tysk C (2004) Lymphocytic colitis: a retrospective clinical study of 199 Swedish patients. Gut 53:536–541

    Article  PubMed  CAS  Google Scholar 

  9. Carpenter HA, Talley NJ (2000) The importance of clinicopathological correlation in the diagnosis of inflammatory conditions of the colon: histological patterns with clinical implications. Am J Gastroenterol 95:878–896

    Article  PubMed  CAS  Google Scholar 

  10. Schiller LR (2004) Diagnosis and management of microscopic colitis syndrome. J Clin Gastroenterol 38:S27–S30

    Article  PubMed  Google Scholar 

  11. Fine KD, Do K, Schulte K, Ogunji F, Guerra R, Osowski L, McCormack J (2000) High prevalence of celiac sprue-like HLA–DQ genes and enteropathy in patients with the microscopic colitis syndrome. Am J Gastroenterol 95:1974–1982

    Article  PubMed  CAS  Google Scholar 

  12. Fine KD, Lee EL (1998) Efficacy of open-label bismuth subsalicylate for the treatment of microscopic colitis. Gastroenterology 114:29–36

    Article  PubMed  CAS  Google Scholar 

  13. Stroehlein JR (2003) Microscopic colitis. Curr Opin Gastroenterol 20:27–31

    Article  Google Scholar 

  14. Matteoni CA, Goldblum JR, Wang N et al (2001) Celiac disease is highly prevalent in lymphocytic colitis. J Clin Gastroenterol 32:225–227

    Article  PubMed  CAS  Google Scholar 

  15. Riddell RH, Tanaka M, Mazzoleni G (1992) Non-steroidal anti-inflammatory drugs as a possible cause of collgenous colitis: a case-control study. Gut 33:683–686

    Article  PubMed  CAS  Google Scholar 

  16. Tremaine WJ (2000) Collagenous colitis and lymphocytic colitis. J Clin Gastroenterol 30:245–249

    Article  PubMed  CAS  Google Scholar 

  17. Tagkaladis P, Bathal P, Gibson P (2002) Microscopic colitis. J Gastroenterol Hepatol 17:236–248

    Article  Google Scholar 

  18. Zins BJ, Sandborn WJ, Tremaine WJ (1995) Collagenous and lymphocytic colitis: a subject to review and therapeutic alternatives. Am J Gastroenterol 90:1394–1400

    PubMed  CAS  Google Scholar 

  19. Pardi DS (2004) Microscopic colitis: an update. Inflamm Bowel Dis 10:860–870

    Article  PubMed  Google Scholar 

  20. Waschke KA, Marcus VA, Bitton A (2002) The atypical colitides. Gastroenterol Clin North Am 3:293–305

    Article  Google Scholar 

  21. Beaugerie L, Luboinsky J, Brousse N et al (1994) Drug induced lymphocytic colitis. Gut 35:426–428

    Article  PubMed  CAS  Google Scholar 

  22. Beaugerie L, Patey N, Brousse N (1995) Ranitidine, diarrhea, and lymphocytic colitis. Gut 37:708–711

    Article  PubMed  CAS  Google Scholar 

  23. Thomson RD, Lestina LS, Bensen SP et al (2002) Lansoprazole-associated microscopic colitis: a case series. Am J Gastroenterol 97:2908–2913

    PubMed  Google Scholar 

  24. Mukherjee S (2003) Diarrhea associated with lansoprazole. J Gastroenterol Hepatol 18:602–603

    Article  PubMed  Google Scholar 

  25. Beaugerie L, Pardi DS (2005) Review article: drug-induced microscopic colitis—proposal for a scoring system and review of the literature. Aliment Pharmacol Ther 22:277–284

    Article  PubMed  CAS  Google Scholar 

  26. Fine KD, Ogunji F, Lee EL et al (1999) Randomized, double blind placebo controlled trial of bismuth subsalicylate for microscopic colitis. Gastroenterology 116:A880

    Article  Google Scholar 

  27. Munk LK, Kjelsen E, Philipsen E et al (2003) Incomplete remission with short-term prednisolone treatment of collagenous colitis: a randomized study. Scand J Gastroenterol 38:606–610

    Article  Google Scholar 

  28. Bonderup OK, Hansen JB, Birket-Smith L et al (2003) Budesonide treatment of collagenous colitis: a randomized, double blind, placebo controlled trial with morphometric analysis. Gut 52:248–251

    Article  PubMed  CAS  Google Scholar 

  29. Pardi DS, Loftus EV, Tremaine WJ et al (2001) Treatment of refractory microscopic colitis with azathioprine and 6-mercaptopurine. Gastroenterology 120:1483–1484

    Article  PubMed  CAS  Google Scholar 

  30. Kitchen PA, Levi AJ, Domizio P, Talbot IC, Forbes A, Price AB (2002) London inflammatory bowel disease forum. Microscopic colitis: the tip of the iceberg? Eur J Gastroenterol Hepatol 14(11):1199–1204

    Article  PubMed  Google Scholar 

  31. Agnarsdottir M, Gunnlaugsson O, Orvar KB, Cariglia N, Birgisson S, Bjornsson S, Thorgeirsson T, Jonasson JG (2002) Collagenous and lymphocytic colitis in Iceland. Dig Dis Sci 47(5):1122–1128

    Article  PubMed  Google Scholar 

  32. Pardi DS, Ramnath VR, Loftus EV Jr, Tremaine WJ, Sandborn WJ (2002) Lymphocytic colitis: clinical features, treatment, and outcomes. Am J Gastroenterol 97(11):2829–2833

    Article  PubMed  Google Scholar 

  33. Abdo A, Raboud J, Freeman HJ, Zetler P, Tilley J, Chaun H, Whittaker JS, Amar J, Halparin L, Enns R (2002) Clinical and histological predictors of response to medical therapy in collagenous colitis. Am J Gastroenterol 97(5):1164–1168

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INNSZ), Vasco de Quiroga 15, Sección XVI. Tlalpan, 14000, Mexico City, Mexico

    Alberto Rubio-Tapia, Julio Martínez-Salgado, Jorge García-Leiva & Misael Uribe

  2. Department of Pathology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (INNSZ), Mexico City, Mexico

    Braulio Martínez-Benítez

Authors
  1. Alberto Rubio-Tapia
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  2. Julio Martínez-Salgado
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  3. Jorge García-Leiva
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  4. Braulio Martínez-Benítez
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  5. Misael Uribe
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Corresponding author

Correspondence to Alberto Rubio-Tapia.

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Rubio-Tapia, A., Martínez-Salgado, J., García-Leiva, J. et al. Microscopic colitides: a single center experience in Mexico. Int J Colorectal Dis 22, 1031–1036 (2007). https://doi.org/10.1007/s00384-006-0258-7

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  • DOI: https://doi.org/10.1007/s00384-006-0258-7

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