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Extremely High Ferritinemia Associated with Haemophagocytic Lympho Histiocytosis (HLH)

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Abstract

Hyperferritinemia (>10,000 ng/ml) is an important hallmark used as an indicator of infection triggered macrophage activation syndrome leading to hemophagocytic lympho histiocytosis (HLH). Measurement of serum ferritin can be used in diagnosis as well as disease monitoring indicator and prognosis related to HLH, cAPS, sepsis, neoplasm and inflammatory conditions. It is a major contributor to manage critically ill patients as predicting and monitoring indicator. It can be used as acute phase response in conditions of MAS, AOSD, cAPS etc. A case study in our hospital showed extremely high ferritin values along with low hemoglobin, elevated LDH and triglycerides with positive MRSA in sputum culture and macrophage proliferation and hemophagocytosis in the bone marrow examination. Patient showed definite inverse relation with steroid therapy and serum ferritin levels.

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Authors and Affiliations

  1. SRL Ltd. Fortis Hospital, Shalimar Bagh, New Delhi, India

    Neelima Verma, Jyoti chakraverty, Pankaj Baweja, Alka Girotra, Leena Chatterjee & Manish Chugh

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  1. Neelima Verma
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  2. Jyoti chakraverty
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  3. Pankaj Baweja
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  4. Alka Girotra
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  5. Leena Chatterjee
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  6. Manish Chugh
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Correspondence to Neelima Verma.

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Authors (Neelima, Jyoti, Pankaj, Alka, Leena and Manish) declare that they have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Verma, N., chakraverty, J., Baweja, P. et al. Extremely High Ferritinemia Associated with Haemophagocytic Lympho Histiocytosis (HLH). Ind J Clin Biochem 32, 117–120 (2017). https://doi.org/10.1007/s12291-016-0559-8

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  • DOI: https://doi.org/10.1007/s12291-016-0559-8

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