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A new triterpene glycoside from the stems of Lagerstroemia indica

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Abstract

A bioassay-guided fractionation and chemical investigation of the stems of Lagerstroemia indica resulted in the isolation and identification of a new triterpene glycoside, lagerindiside (1), along with nine known triterpenes (2–10). The structure of this new compound was elucidated on the basis of 1D and 2D nuclear magnetic resonance spectroscopic data analysis as well as chemical method. The cytotoxic activities of the isolates (1–10) were evaluated by determining their inhibitory effects on four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15) using a sulforhodamine B bioassay. Compounds 3 and 4 showed potent cytotoxicity on the tumor cell lines with IC50 values ranging from 3.38 to 6.29 μM.

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Acknowledgments

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science and Technology (2013R1A1A2A10005315). We are thankful to the Korea Basic Science Institute (KBSI) for the measurements of NMR and MS spectra.

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Authors and Affiliations

  1. Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-ku, Suwon, Gyeonggi-do, 440-746, Republic of Korea

    Kyeong Wan Woo, Joon Min Cha & Kang Ro Lee

  2. Korea Research Institute of Chemical Technology, Daejeon, 305-600, Republic of Korea

    Sang Un Choi

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  1. Kyeong Wan Woo
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  2. Joon Min Cha
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  3. Sang Un Choi
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  4. Kang Ro Lee
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Correspondence to Kang Ro Lee.

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Woo, K.W., Cha, J.M., Choi, S.U. et al. A new triterpene glycoside from the stems of Lagerstroemia indica . Arch. Pharm. Res. 39, 631–635 (2016). https://doi.org/10.1007/s12272-016-0746-4

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  • DOI: https://doi.org/10.1007/s12272-016-0746-4

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