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Characterization of the physicochemical properties of KRK-701P

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Abstract

KRK-701P is a broad-spectrum antibiotic with methicillin-resistant antibacterial activity. The objective of this preformulation study was to determine the physicochemical properties of KRK-701P. The n-octanol-to-water partition coefficients of KRK-701P were 0.448 at pH 4 and 2.546 at pH 8. One crystal form and one amorphous form of KRK-701P were isolated by recrystallization and characterized by differential scanning calorimetry, powder X-ray diffractometry and thermogravimetric analysis. After storage for 1 month at 0 % RH (silica gel, 20 °C), 52 % RH (saturated solution of Na2Cr2O7.2H2O/20 °C) and 95 % RH (saturated solution of Na2HPO4/20 °C), the two forms were not transformed.

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Authors and Affiliations

  1. College of Pharmacy, Duksung Women’s University, 419, Ssangmun-Dong, Dobong-Gu, 132-714, Seoul, Korea

    In Jeong Bang & Young Taek Sohn

  2. Cancer and In. Diseases Therapeutics Research Group, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong, 305-600, Daejeon, Korea

    Bong Jin Kim

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  1. In Jeong Bang
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  2. Bong Jin Kim
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Correspondence to Young Taek Sohn.

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Bang, I.J., Kim, B.J. & Sohn, Y.T. Characterization of the physicochemical properties of KRK-701P. Arch. Pharm. Res. 38, 834–838 (2015). https://doi.org/10.1007/s12272-014-0450-1

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  • DOI: https://doi.org/10.1007/s12272-014-0450-1

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