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Application of Adipose-Derived Stem Cells in Heart Disease

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Journal of Cardiovascular Translational Research Aims and scope Submit manuscript

Abstract

Therapy with mesenchymal stem cells is one of the promising tools to improve outcomes after myocardial infarction. Adipose-derived stem cells (ASCs) are an ideal source of mesenchymal stem cells due to their abundance and ease of preparation. Studies in animal models of myocardial infarction have demonstrated the ability of injected ASCs to engraft and differentiate into cardiomyocytes and vasculature cells. ASCs secrete a wide array of angiogenic and anti-apoptotic paracrine factors such as vascular endothelial growth factor, hepatocyte growth factor, and insulin-like growth factor 1. ASCs are capable of enhancing heart function, reducing myocardial infarction, promoting vascularization, and reversing remodeling in the ischemically injured hearts. Furthermore, several ongoing clinical trials using ASCs are producing promising results for heart diseases. This article reviews the isolation, differentiation, immunoregulatory properties, mechanisms of action, animal models, and ongoing clinical trials of ASCs for cardiac disease.

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Abbreviations

ASCs:

Adipose-derived stem cells

MI:

Myocardial infarction

MSCs:

Mesenchymal stem cells

BM:

Bone marrow

SVF:

Stromal vascular fraction

VEGF:

Vascular endothelial growth factor

COX-2:

Cyclooxygenase-2

PGE-2:

Prostaglandin E2

HGF:

Hepatocyte growth factor

Tregs:

Regulatory T cells

GVHD:

Graft-versus-host disease

IGF-I:

Insulin-like growth factor 1

eNOS:

Endothelial nitric oxide synthase

ADRCs:

Adipose-derived stem and regenerative cells

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Funding

This work was supported by the National Natural Science Foundation of China (81270068), Zhejiang Health Bureau Cultivation Plan (2014PYA020), and Shaoxing 330 Plan to JX and the National Natural Science Foundation of China (81272139) and the National Science and Technology Support Program (2012BAI04B05) to QS.

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The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Shaoxing Second Hospital, Shaoxing, Zhejiang, China

    Lina Chen, Fengming Qin, Menghua Ge & Jianguo Xu

  2. Children’s Hospital, Zhejiang University, Shaoxing, Zhejiang, China

    Qiang Shu

  3. First Affiliated Hospital, Zhejiang University, Shaoxing, Zhejiang, China

    Jianguo Xu

  4. Shaoxing Second Hospital, Zhejiang University, 123 Yan’an Road, Shaoxing, 312000, Zhejiang, China

    Jianguo Xu

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  1. Lina Chen
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  2. Fengming Qin
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  3. Menghua Ge
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  4. Qiang Shu
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  5. Jianguo Xu
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Correspondence to Jianguo Xu.

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Editor-in-Chief Jennifer L. Hall oversaw the review of this article

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Chen, L., Qin, F., Ge, M. et al. Application of Adipose-Derived Stem Cells in Heart Disease. J. of Cardiovasc. Trans. Res. 7, 651–663 (2014). https://doi.org/10.1007/s12265-014-9585-1

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