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Xanthogranulomatous Cholecystitis: Analysis of 108 Patients

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Abstract

The aim of this study was to evaluate the clinical and radiological features of xanthogranulomatous cholecystitis (XGC) and the results of surgical treatment. This retrospective study concerns clinical, radiological, and surgical data as well as histopathological findings and postoperative results of 108 patients with XGC who were identified after evaluating 7916 cholecystectomy specimens between 2004 and 2014 in a single institute. One hundred eight patients with XGC were evaluated (56 males and 52 females, mean age 62.3 years). Clinical findings at referral included acute and chronic cholecystitis, Mirizzi’s syndrome, choledocholithiasis, cholangitis, and acute pancreatitis. Ultrasound was performed in all patients, CT in 25, contrast-enhanced MRI in 29, and magnetic resonance cholangiopancreatography (MRCP) in 25 patients. None of the patients were diagnosed preoperatively, but mild-moderate degrees of wall thickening were present in most. Fifty-four patients received open cholecystectomy, while 54 received laparoscopic intervention, among whom 23 were converted to open. Partial cholecystectomy was performed in 11 patients. Two patients with gallbladder adenocarcinoma were treated with radical cholecystectomy. XGC has nonspecific clinical and radiological findings; thus, preoperative diagnosis is generally absent. Open cholecystectomy is the recommended treatment modality. Conversion to open is frequently necessary after laparoscopy. Complete cholecystectomy is the ultimate goal; however, partial cholecystectomy may be preferred to protect the structures of the hepatic hilum.

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Authors and Affiliations

  1. Department of General Surgery, Haydarpasa Numune Training and Research Hospital, Tıbbiye Cad. No: 23, Uskudar, Istanbul, Turkey

    Osman Yucel, Mehmet Ali Uzun, Metin Tilki & Sevcan Alkan

  2. Semsettin Gunaltay Cad. No: 159/36, Erenkoy, Kadikoy, Istanbul, Turkey

    Osman Yucel

  3. Department of Radiology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey

    Zeynep Gamze Kilicoglu

  4. Department of Pathology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey

    Ceren Canbey Goret

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  1. Osman Yucel
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  2. Mehmet Ali Uzun
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  5. Zeynep Gamze Kilicoglu
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Correspondence to Osman Yucel.

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Yucel, O., Uzun, M.A., Tilki, M. et al. Xanthogranulomatous Cholecystitis: Analysis of 108 Patients. Indian J Surg 79, 510–514 (2017). https://doi.org/10.1007/s12262-016-1511-0

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  • DOI: https://doi.org/10.1007/s12262-016-1511-0

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