Skip to main content
Log in

Kommentar zur 2014-Leitlinie der Europäischen Gesellschaft für Kardiologie (ESC) zur Diagnose und Therapie von Aortenerkrankungen

Comments on the 2014 guidelines of the European Society of Cardiology on the diagnosis and therapy of aortic diseases

  • Leitlinien
  • Published:
Der Kardiologe Aims and scope

Zusammenfassung

Erstmals fasst die Europäische Gesellschaft für Kardiologie in einer Leitlinie die Diagnose und Therapie von Erkrankungen der gesamten Aorta zusammen. Sie wünscht die Bildung von Aortenteams als Basis von Aortenzentren, die zukünftig europaweit zusammenarbeiten sollten. Im Vordergrund stehen die Diagnostik und Therapie der akuten Aortensyndrome, worunter die klassische Aortendissektion, das intramurale Hämatom, das penetrierende Aortenulkus, die traumatische Aortenruptur wie auch die iatrogene Aortenverletzung zusammengefasst werden. Ein diagnostischer Algorithmus für die Notaufnahme soll dazu beitragen, keine unnötigen diagnostischen Maßnahmen zu treffen und eine rasche Diagnosestellung zu ermöglichen als Basis für ein optimiertes therapeutisches chirurgisches und/oder interventionelles Verfahren. Für alle Kardiologen ist der Hinweis wichtig, dass bei Männern und Raucherinnen über 65 Jahren ein Screening auf ein abdominelles Aortenaneurysma durchgeführt werden soll, was z. B. im Anschluss an eine transthorakale Echokardiographie angeschlossen werden kann. Das therapeutische Vorgehen bei asymptomatischen und symptomatischen Patienten mit abdominellem Aortenaneurysma wird beschrieben. Ausführlich werden genetische Erkrankungen der Aorta sowie atherosklerotische und entzündliche Erkrankungen dargelegt. Wertvolle Hinweise gibt es für notwendige Verlaufsuntersuchungen im chronischen Stadium von Aortenerkrankungen.

Abstract

For the first time the European Society of Cardiology has presented guidelines for the diagnosis and therapy of aortic diseases involving parts as well as the total aorta. Desirable are the formation of aortic teams and the establishment of aortic centers, which should cooperate in a European effort. The diagnosis and therapy of acute aortic syndromes, including classical aortic dissection, intramural hematoma, penetrating aortic ulcer, traumatic aortic injury as well as iatrogenic aortic dissection are discussed and a diagnostic algorithm for emergency departments presented. The diagnostic algorithm should allow a rapid diagnosis and initiation of an optimal surgical and/or interventional therapy, not neglecting medical options . For cardiologists it is important to know that all men and women smokers > 65 years should be screened for the presence of an abdominal aortic aneurysm. Using transthoracic echocardiography a brief ultrasound scan of the abdominal aorta can be recommended as a screening method. The therapeutic options in asymptomatic and symptomatic patients with abdominal aortic aneurysms are described. Genetic diseases of the aorta as well as atherosclerotic and inflammatory diseases are listed. Important advice is given for follow-up studies in patients with aortic diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. Erbel R, Aboyans V, Boileau C, Bossone E, Bartolomeo RD, Eggebrecht H, Evangelista A, Falk V, Frank H, Gaemperli O, Grabenwöger M, Haverich A, Iung B, Manolis AJ, Meijboom F, Nienaber CA, Roffi M, Rousseau H, Sechtem U, Sirnes PA, Allmen RS, Vrints CJ, ESC Committee for Practice Guidelines (2014) ESC Guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC). Eur Heart J 35:2873–2926

    Article  PubMed  Google Scholar 

  2. Erbel R, Alfonso F, Boileau C, Dirsch O, Eber B, Haverich A, Rakowski H, Struyven J, Radegran K, Sechtem U, Taylor J, Zollikofer C, Klein WW, Mulder B, Providencia LA, Task Force on Aortic Dissection, European Society of Cardiology (2001) Diagnosis and management of aortic dissection. Eur Heart J 22:1642–1681

    Article  CAS  PubMed  Google Scholar 

  3. Sampat U, Varadarajan P, Turk R, Kamath A, Khandhar S, Pai RG (2009) Effect of beta-blocker therapy on survival in patients with severe aortic regurgitation results from a cohort of 756 patients. J Am Coll Cardiol 54:452–457

    Article  PubMed  Google Scholar 

  4. Groenink M, den Hartog AW, Franken R, Radonic T, de Waard V, Timmermans J, Scholte AJ, van den Berg MP, Spijkerboer AM, Marquering HA, Zwinderman AH, Mulder BJ (2013) Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial. Eur Heart J 34:3491–3500

    Article  CAS  PubMed  Google Scholar 

  5. Stein LH, Berger J, Tranquilli M, Elefteraides JA (2013) Effect of statin drugs on thoracic aortic aneurysms. Am J Cardiol 112:1240–1245

    Article  CAS  PubMed  Google Scholar 

  6. Grabenwöger M, Alfonso F, Bachet J, Bonser R, Czerny M, Eggebrecht H, Evangelista A, Fattori R, Jakob H, Lönn L, Nienaber CA, Rocchi G, Rousseau H, Thompson M, Weigang E, Erbel R (2012) Thoracic Endovascular Aortic Repair (TEVAR) for the treatment of aortic diseases: a position statement from the European Association for Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J 33:1558–1563

    Article  PubMed  Google Scholar 

  7. Eggebrecht H, Herold U, Schmermund A, Lind AY, Kuhnt O, Martini S, Kühl H, Kienbaum P, Peters J, Jakob H, Erbel R, Baumgart D (2006) Endovascular stent-graft treatment of penetrating aortic ulcer: results over a median follow-up of 27 months. Am Heart J 151:530–536

    Article  PubMed  Google Scholar 

  8. Eggebrecht H, Thompson M, Rousseau H, Czerny M, Lönn L, Mehta RH, Erbel R (2009) European Registry on Endovascular Aortic Repair Complications. Retrograde ascending aortic dissection during or after thoracic aortic stent graft placement: insight from the European registry on endovascular aortic repair complications. Circulation 120(11):276–281

    Article  Google Scholar 

  9. Jakob H, Dohle DS, Piotrowski J, Benedik J, Thielmann M, Marggraf G, Erbel R, Tsagakis K (2012) Six-year experience with a hybrid stent graft prosthesis for extensive thoracic aortic disease: an interim balance. Eur J Cardiothorac Surg 42:1018–1025

    Article  PubMed  Google Scholar 

  10. Shrestha M, Baraki H, Maeding I, Fitzner S, Sarikouch S, Khaladj N, Hagl C, Haverich A (2012) Long-term results after aortic valve-sparing operation (David I). Eur J Cardiothorac Surg 41:56–61 (discussion 61-62)

    Article  PubMed Central  PubMed  Google Scholar 

  11. Leontyev S, Borger MA, Etz CD, Moz M, Seeburger J, Bakhtiary F, Misfeld M, Mohr FW (2013) Experience with the conventional and frozen elephant trunk techniques: a single-centre study. Eur J Cardiothorac Surg 44:1076–1082 (discussion 1083)

    Article  PubMed  Google Scholar 

  12. Nienaber CA, Rousseau H, Eggebrecht H, Kische S, Fattori R, Rehders TC, Kundt G, Scheinert D, Czerny M, Kleinfeldt T, Zipfel B, Labrousse L, Ince H (2009) INSTEAD Trial. Randomized comparison of strategies for type B aortic dissection: the Investigation of Stent Grafts in Aortic Dissection (INSTEAD) trial. Circulation 120:2519–2528

    Article  PubMed  Google Scholar 

  13. Nienaber CA, Kische S, Rousseau H, Eggebrecht H, Rehders TC, Kundt G, Glass A, Scheinert D, Czerny M, Kleinfeldt T, Zipfel B, Labrousse L, Fattori R, Ince H (2013) INSTEAD-XL trial. Endovascular repair of type B aortic dissection: long-term results of the randomized investigation of stent grafts in aortic dissection trial. Circ Cardiovasc Interv 6:407–416

    Article  CAS  PubMed  Google Scholar 

  14. Song JK (2011) Aortic intramural hematoma: aspects of pathogenesis 2011. Herz 36:488–497

    Article  PubMed  Google Scholar 

  15. Evangelista A, Dominguez R, Sebastia C, Salas A, Permanyer-Miralda G, Avegliano G, Gomez-Bosh Z, Gonzalez-Alujas T, Garcia del Castillo H, Soler-Soler J (2004) Prognostic value of clinical and morphologic findings in short-term evolution of aortic intramural haematoma. Therapeutic implications. Eur Heart J 25:81–87

    Article  PubMed  Google Scholar 

  16. Nathan DP, Boonn W, Lai E, Wang GJ, Desai N, Woo EY, Fairman RM, Jackson BM (2012) Presentation, complications, and natural history of penetrating atherosclerotic ulcer disease. J Vasc Surg 55:10–15

    Article  PubMed  Google Scholar 

  17. Cho KR, Stanson AW, Potter DD, Cherry KJ, Schaff HV, Sundt TM 3rd (2004) Penetrating atherosclerotic ulcer of the descending thoracic aorta and arch. J Thorac Cardiovasc Surg 127:1393–1399

    Article  PubMed  Google Scholar 

  18. Azizzadeh A, Keyhani K, Miller CC 3rd, Coogan SM, Safi HJ, Estrera AL (2009) Blunt traumatic aortic injury: initial experience with endovascular repair. J Vasc Surg 49:1403–1408

    Article  PubMed  Google Scholar 

  19. Januzzi JL, Sabatine MS, Eagle KA, Evangelista A, Bruckman D, Fattori R, Oh JK, Moore AG, Sechtem U, Llovet A, Gilon D, Pape L, O’Gara PT, Mehta R, Cooper JV, Hagan PG, Armstrong WF, Deeb GM, Suzuki T, Nienaber CA, Isselbacher EM (2002) International Registry of Aortic Dissection Investigators. Latrogenic aortic dissection. Am J Cardiol 89:623–626

    Article  PubMed  Google Scholar 

  20. Núñez-Gil IJ, Bautista D, Cerrato E, Salinas P, Varbella F, Omedè P, Ugo F, [] Ielasi A, Giammaria M, Moreno R, Pérez-Vizcayno MJ, Escaned J, de Agustin JA, Feltez G, Macaya C, Fernández-Ortiz A (2015) RAID (Registry on Aortic Iatrogenic Dissection) Investigators. Incidence, management, immediate and long-term outcomes following Iatrogenic Aortic Dissection during diagnostic or interventional coronary procedures. Circulation 131:2114–2119

  21. Jonker FH, Trimarchi S, Verhagen HJ, Moll FL, Sumpio BE, Muhs BE (2010) Meta-analysis of open versus endovascular repair for ruptured descending thoracic aortic aneurysm. J Vasc Surg 51:1026–1032

    Article  PubMed  Google Scholar 

  22. Brady AR, Thompson SG, Fowkes FG, Greenhalgh RM, Powell JT (2004) UK small aneurysm trial participants. Abdominal aortic aneurysm expansion: risk factors and time intervals for surveillance. Circulation 110:16–21

    Article  PubMed  Google Scholar 

  23. Badger SA, Jones C, McClements J, Lau LL, Young IS, Patterson CC (2011) Surveillance strategies according to the rate of growth of small abdominal aortic aneurysms. Vasc Med 16:415–421

    Article  PubMed  Google Scholar 

  24. Takagi H, Goto SN, Matsui M, Manabe H, Umemoto T (2010) A further meta-analysis of population-based screening for abdominal aortic aneurysm. J Vasc Surg 52:1103–1108

    Article  PubMed  Google Scholar 

  25. Aboyans V, Bataille V, Bliscaux P, Ederhy S, Filliol D, Honton B, Kurtz B, Messas E, Mohty D, Brochet E, Kownator S, investigators of the E2T3 A study (2014) Effectiveness of screening for abdominal aortic aneurysm during echocardiography. Am J Cardio 114:1100–1104

    Article  Google Scholar 

  26. Aboyans V, Kownator S, Lafitte M, Brochet E, Emmerich J, Tribouilloy C, Lafitte S, Working Group for Vascular Diseases/Thrombosis, French Society of Cardiology, Council of Echocardiography, Ferrini M (2010) Screening abdominal aorta aneurysm during echocardiography: literature review and proposal for a French nationwide study. Arch Cardiovasc Dis 103:552–558

    Article  PubMed  Google Scholar 

  27. Lederle FA, Wilson SE, Johnson GR, Reinke DB, Littooy FN, Acher CW, Ballard DJ, Messina LM, Gordon IL, Chute EP, Krupski WC, Busuttil SJ, Barone GW, Sparks S, Graham LM, Rapp JH, Makaroun MS, Moneta GL, Cambria RA, Makhoul RG, Eton D, Ansel HJ, Freischlag JA, Bandyk D, Aneurysm Detection and Management Veterans Affairs Cooperative Study Group (2002) Immediate repair compared with surveillance of small abdominal aortic aneurysms. N Engl J Med 346:1437–1444

    Article  PubMed  Google Scholar 

  28. The UK Small Aneurysm Trial Participants (1998) Mortality results for randomised controlled trial of early elective surgery or ultrasonographic surveillance for small abdominal aortic aneurysms. Lancet 352:1649–1655

  29. Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Barón-Esquivias G, Baumgartner H, Borger MA, Carrel TP, De Bonis M, Evangelista A, Falk V, Lung B, Lancellotti P, Pierard L, Price S, Schäfers HJ, Schuler G, Stepinska J, Swedberg K, Takkenberg J, Von Oppell UO, Windecker S, Zamorano JL, Zembala M, Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC), European Association for Cardio-Thoracic Surgery (EACTS) (2012) Guidelines on the management of valvular heart disease (version 2012). Eur Heart J 33:2451–2496

    Article  PubMed  Google Scholar 

  30. Baumgartner H, Bonhoeffer P, De Groot NM, de Haan F, Deanfield JE, Galie N, Gatzoulis MA, Gohlke-Baerwolf C, Kaemmerer H, Kilner P, Meijboom F, Mulder BJ, Oechslin E, Oliver JM, Serraf A, Szatmari A, Thaulow E, Vouhe PR, Walma E, Task Force on the Management of Grown-up Congenital Heart Disease of the European Society of Cardiology (ESC), Association for European Paediatric Cardiology (AEPC), ESC Committee for Practice Guidelines (CPG) (2010) ESC Guidelines for the management of grown-up congenital heart disease (new version 2010). Eur Heart J 31:2915–2957

    Article  PubMed  Google Scholar 

  31. Gornik HL, Creager MA (2008) Aortitis. Circulation 117:3039–3051

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to R. Erbel.

Ethics declarations

Interessenkonflikt

Den Interessenkonflikt der Autoren finden Sie online auf der DGK-Homepage unter http://leitlinien.dgk.org/ bei der entsprechenden Publikation.

Dieser Beitrag beinhalten keine Studien an Menschen und Tieren.

Additional information

Dieser Kommentar wurde koordiniert von C. Nienaber für die Kommission für Klinische Kardiologie der Deutschen Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e. V.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Erbel, R., Eggebrecht, H., Falk, V. et al. Kommentar zur 2014-Leitlinie der Europäischen Gesellschaft für Kardiologie (ESC) zur Diagnose und Therapie von Aortenerkrankungen. Kardiologe 9, 348–353 (2015). https://doi.org/10.1007/s12181-015-0018-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12181-015-0018-4

Schlüsselwörter

Keywords

Navigation