Review Article

Hepatology International

, Volume 2, Issue 3, pp 335-340

Open Access This content is freely available online to anyone, anywhere at any time.

The effect of iron depletion on chronic hepatitis C virus infection

  • Massimo FranchiniAffiliated withServizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Ospedale Policlinico, Piazzale Ludovico Scuro Email author 
  • , Giovanni TargherAffiliated withSezione di Endocrinologia e Malattie del Metabolismo, Dipartimento di Scienze Biomediche e Chirurgiche, Università di Verona
  • , Franco CapraAffiliated withMedicina Interna C, Dipartimento di Scienze Biomediche e Chirurgiche, Università di Verona
  • , Martina MontagnanaAffiliated withIstituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università di Verona
  • , Giuseppe LippiAffiliated withIstituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università di Verona

Abstract

Increasing evidence exists that iron overload, a common finding in chronic hepatitis C virus (HCV) infection, plays an important role in the pathophysiology of this disease. The mechanisms by which iron excess induces liver damage along with the benefit of iron depletion via phlebotomy on biochemical and histological outcomes in patients with chronic HCV infection have been discussed in this review. Finally, we focus on the effect of iron reduction on the rate of response to interferon antiviral therapy.

Keywords

Iron Phlebotomy HCV IFN Therapy