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Synthesis and antibacterial activity screening of quaternary ammonium derivatives of triazolyl pyranochromenones

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Abstract

A series of quaternary ammonium derivatives of triazolyl pyranochromen-2-ones have been synthesized and characterized; their antibacterial potential were investigated against two gram negative (Pseudomonas aeruginosa and Escherichia coli) and two gram positive bacterial strains (Bacillus cereus and Staphylococcus aureus). In order to develop structure-activity relationship (SAR), the effect of varying the substituent (R) at the C-10 position of pyranochromen-2-one as well as the length of the spacer (n) between the triazolyl pyranochromen-2-ones and quaternary ammonium group, on the antibacterial activity of compounds has been evaluated. Some of the screened compounds exhibited antibacterial potential against the studied strains in the microgram range.

A series of quaternary ammonium derivatives of triazolyl pyranochromen-2-ones have been synthesized, characterized AND their antibacterial potential investigated. In order to develop structure-activity relationship (SAR), the effect of varying the substituent (R) at the C-10 position of pyranochromen-2-one as well as the length of the spacer (n) between the triazolyl pyranochromen-2-ones and quaternary ammonium group, on the antibacterial activity of compounds has been evaluated.

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Acknowledgements

We gratefully acknowledge the financial assistance from the University of Delhi for the DU-DST PURSE Grant and Council of Scientific and Industrial Research (CSIR) task force project (BSC0302). The author PY is thankful to Council of Scientific and Industrial Research (CSIR, New Delhi) for the award of Junior/Senior Research Fellowships.

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Authors and Affiliations

  1. Department of Chemistry, University of Delhi, Delhi, 110 007, India

    PREETI YADAV & SUNIL K SHARMA

  2. CSIR-Institute of Genomics and Integrative Biology, Sukhdev Vihar, Mathura Road, Delhi, 110 025, India

    BIPUL KUMAR & HEMANT K GAUTAM

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  1. PREETI YADAV
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  2. BIPUL KUMAR
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  3. HEMANT K GAUTAM
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Correspondence to SUNIL K SHARMA.

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YADAV, P., KUMAR, B., GAUTAM, H.K. et al. Synthesis and antibacterial activity screening of quaternary ammonium derivatives of triazolyl pyranochromenones. J Chem Sci 129, 211–222 (2017). https://doi.org/10.1007/s12039-016-1214-x

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  • DOI: https://doi.org/10.1007/s12039-016-1214-x

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