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Synthesis, X-ray crystal structure, DNA binding and Nuclease activity of lanthanide(III) complexes of 2-benzoylpyridine acetylhydrazone

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Abstract

Lanthanide(III) complexes of general formula [La(BPAH)2(NO3)3] and [Ce(BPAH)2(NO3)(H2O)2] 2NO3.H2O (where, BPAH = 2-benzoylpyridine acetyl hydrazone), were synthesized and characterized by elemental analysis, molar conductance, IR spectroscopy and single crystal X-ray diffraction and Hirschfeld studies. The central metal ion is 12-coordinate in lanthanum complex and 10-coordinated in the cerium complex. The coordination polyhedra around the lanthanum and cerium were found to have distorted icosahedron and distorted bicapped square antiprism respectively. DNA binding and nuclease activity of these complexes were also investigated in the present work.

Lanthanide(III) complexes of general formula [La(BPAH)2(NO3)3] and [Ce(BPAH)2(NO3)(H2O)2].2NO3.H2O (where, BPAH = 2-benzoylpyridine acetyl hydrazone), were synthesized and characterized by elemental analysis, molar conductance, IR spectroscopy, single crystal X-ray diffraction and Hirschfeld studies. DNA binding and nuclease activity of these complexes were also investigated in the present work.

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Acknowledgements

One of the authors (K. Raja) is thankful to UGC, New Delhi for the award Project Fellow. The authors are thankful to UGC, New Delhi [Sanction No. Lr.No.F 40-80/2011(SR)] for financial support. KHR is thankful to U.G.C for sanction of one time financial grant [Sanction No. F 19-106/2013(BSR)]. We are also thankful to SAIF, IIT-Madras for providing x-ray crystallographic data. The authors also thank UGC and DST for providing equipment facility under SAP and FIST programs respectively.

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Authors and Affiliations

  1. Department of Chemistry, Sri Krishnadevaraya University, Anantapur, 515 003, India

    KARREDDULA RAJA, AKKILI SUSEELAMMA & KATREDDI HUSSAIN REDDY

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  1. KARREDDULA RAJA
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  2. AKKILI SUSEELAMMA
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Correspondence to KATREDDI HUSSAIN REDDY.

Additional information

Supplementary Information (SI)

CCDC 945920 & CCDC 917696 contains the supplementary crystallographic data for La and Ce complexes. These data can be obtained free of charge via http://www.ccdc.cam.ac.uk/conts/retrieving.html, or from the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: + 44 1223 336 033; or e-mail: deposit@ccdc.cam.ac.uk. Figures S1 and S2 shows the X-H... π intra molecular interactions for the La and Ce complexes respectively, Figure S3 shows the hydrogen bond network of Ce complex, Figures S4 and S5 shows the absorption spectra of La and Ce complexes respectively and Figures S6 and S7 show nuclease activity of La and Ce complexes respectively Tables S1 and S2 lists the hydrogen bonds(Å) and angles (°) for La and Ce complexes respectively. “Supplementary information is available at www.ias.ac.in/chemsci”.

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RAJA, K., SUSEELAMMA, A. & REDDY, K.H. Synthesis, X-ray crystal structure, DNA binding and Nuclease activity of lanthanide(III) complexes of 2-benzoylpyridine acetylhydrazone. J Chem Sci 128, 1265–1275 (2016). https://doi.org/10.1007/s12039-016-1125-x

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  • DOI: https://doi.org/10.1007/s12039-016-1125-x

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