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Association Between Interleukin-1A, Interleukin-1B, and Bridging integrator 1 Polymorphisms and Alzheimer’s Disease: a standard and Cumulative Meta-analysis

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Abstract

Alzheimer’s disease (AD) has been one of the most prevalent health problems among senior population. Interleukin-1A (IL-1A) and IL-1B are two isoforms of IL-1. Recent studies suggested that certain polymorphisms on these two genes are associated with AD. Bridging integrator 1 (BIN1) is considered as common genetic risk factors for AD, whereas different studies have provided various conclusions regarding its role in AD. This study was designed to justify the association between multiple gene polymorphisms and AD through an evidence synthesis approach. We conducted a literature search to identify relevant articles published from 2000 to 2015 from PubMed, Embase, and Cochrane Library, in accordance with inclusion criteria. Pooled odds ratios (ORs) were calculated for the allele model. The effect estimates were summarized by both standard and cumulative meta-analysis. Finally, 54 articles with 88 independent studies were enrolled in this meta-analysis. Mutants in rs1800587 of IL-1A, rs1143634 of IL-1B, rs12989701, and rs744373 of BIN1 were significantly associated with AD onset. The difference effect of same single nucleotide polymorphisms (SNPs) on various ethnicities was also observed in our results. The present meta-analysis suggested that IL-1A, IL-1B, and BIN1 were candidate genes for AD pathogenesis. Polymorphisms of IL-1A, IL-1B, and BIN1 are associated with AD onset.

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Authors and Affiliations

  1. Department of Neurology, Tangshan People’s Hospital, Tangshan, 063000, China

    Xiaoliu Dong

  2. Department of Neurosurgery, Tangshan People’s Hospital, Tangshan, 063000, China

    Li Zhang

  3. Department of Internal Medicine, The People’s Hospital of Qianxi County, Qianxi, 064300, China

    Qingling Meng

  4. Department of Ultrasound, Tangshan People’s Hospital, Tangshan, 063000, China

    Qiuyan Gao

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Correspondence to Xiaoliu Dong.

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Figure S1

Cumulative meta-analysis of rs1143627 polymorphism in IL-1B gene (GIF 8 kb)

High resolution image (EPS 1084 kb)

Figure S2

Cumulative meta-analysis of rs16944 polymorphism in IL-1B gene (GIF 27 kb)

High resolution image (EPS 1225 kb)

Figure S3

Cumulative meta-analysis of rs7561528 polymorphism in BIN1 gene (GIF 6 kb)

High resolution image (EPS 1074 kb)

Figure S4

Funnel plot of publication bias for rs1800587 polymorphism in IL-1A gene (A), rs1143634 polymorphism in IL-1B gene (B), rs12989701 (C) and rs744373 (D) polymorphisms in BIN1 gene (GIF 83 kb)

High resolution image (EPS 1906 kb)

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Dong, X., Zhang, L., Meng, Q. et al. Association Between Interleukin-1A, Interleukin-1B, and Bridging integrator 1 Polymorphisms and Alzheimer’s Disease: a standard and Cumulative Meta-analysis. Mol Neurobiol 54, 736–747 (2017). https://doi.org/10.1007/s12035-015-9683-3

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  • DOI: https://doi.org/10.1007/s12035-015-9683-3

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