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The crosstalk between long non-coding RNAs and PI3K in cancer

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Abstract

Long non-coding RNAs (lncRNAs) are able to positively or negatively regulate other genes expression in cis or in trans. Their effect can be achieved through RNA–protein, RNA–DNA, or RNA–RNA interactions. They can recruit transcription factors and act as scaffolds or guides for chromatin-modifying enzymes. PI3K kinases transform external stimuli to intracellular signals regulating cell growth, differentiation, proliferation, survival, intracellular trafficking, cytoskeletal changes, cell migration and motility, and metabolism. PI3K is activated in cancer and affects several aspects of oncogenesis. LncRNAs and PI3K have been shown to be interconnected in several different cancer subtypes enhancing aberrant cell proliferation, epithelial-to-mesenchymal transition, migration and invasion, and also cancer cell metabolism. In this review, we have assembled recent data describing the interaction between lncRNAs and PI3K and the results of such interaction.

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Authors and Affiliations

  1. Blood Bank, Preveza General Hospital, Selefkeias 2, 48100, Preveza, Greece

    Leonidas Benetatos

  2. Department of Medical Oncology, 424 Military Hospital, Thessaloniki, Greece

    Evangelos Voulgaris

  3. Molecular Biology Laboratory, Ioannina University Hospital, Ioannina, Greece

    Georgios Vartholomatos

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  1. Leonidas Benetatos
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  2. Evangelos Voulgaris
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  3. Georgios Vartholomatos
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Correspondence to Leonidas Benetatos.

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LB, EV, and GV declare that they have no conflict of interest.

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Benetatos, L., Voulgaris, E. & Vartholomatos, G. The crosstalk between long non-coding RNAs and PI3K in cancer. Med Oncol 34, 39 (2017). https://doi.org/10.1007/s12032-017-0897-2

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