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Roles of FoxM1 in cell regulation and breast cancer targeting therapy

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Abstract

Forkhead box M1 (FoxM1) is an oncogenic transcription factor involved in a wide variety of cellular processes, such as cell cycle progression, proliferation, differentiation, migration, metabolism and DNA damage response. It is overexpressed in many human cancers, especially in breast cancers. Posttranslational modifications are known to play an important role in regulating the expression and transcriptional activity of FoxM1. In this review, we characterize the posttranslational modifications of FoxM1, summarize modifications of FoxM1 by different kinases, explore the relationship between the different sites of modifications and comprehensively describe how posttranslational modifications to regulate the function of FoxM1 by changing protein stability, nucleus localization and transcriptional activity. Additionally, we systematically summarize the roles of FoxM1 in breast cancer occurrence, therapy and drug resistance. The purpose of this paper tries to give a better understanding of the regulatory mechanisms of FoxM1 in cell regulation and highlights potential of a new method for breast cancer therapy by targeting FoxM1.

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Acknowledgements

This work was partly supported by the National Nature Science Foundation of China (Grant Nos 21405138 and 81273111), the Scientific Projects of Zhejiang Province (2015C33148 and 2015C37117), the Foundations of Innovative Research Team of Educational Commission of Zhejiang Province (T200907), Ningbo Scientific Innovation Team for Environmental Hazardous Factor Control and Prevention (2016C51001) and KC Wong Magna Fund in Ningbo University.

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  1. Department of Preventative Medicine, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Medicine School of Ningbo University, 818 Fenghua Road, Ningbo, 315211, Zhejiang, People’s Republic of China

    Xin Song, Samuel Selorm Fiati Kenston, Jinshun Zhao, Danting Yang & Yuanliang Gu

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  1. Xin Song
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  2. Samuel Selorm Fiati Kenston
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  3. Jinshun Zhao
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  4. Danting Yang
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Correspondence to Danting Yang or Yuanliang Gu.

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Song, X., Fiati Kenston, S.S., Zhao, J. et al. Roles of FoxM1 in cell regulation and breast cancer targeting therapy. Med Oncol 34, 41 (2017). https://doi.org/10.1007/s12032-017-0888-3

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