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Association of follicular lymphoma risk with BRCA2 N372H Polymorphism in Slovak population

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Abstract

Follicular lymphoma (FL) is one of the most common Non-Hodgkin lymphoma (NHL) subtype. Only small number of studies concerning NHL and DNA reparation gene polymorphisms has been performed so far. Hence, we have assessed the effect of 4 selected polymorphisms with possible influence on risk of FL development in a case–control study in Slovak population. We have genotyped polymorphisms in the RAG1 (K820R), LIG4 (T9I), BRCA2 (N372H), and WRN (V114I) genes in 108 patients with histologically proven FL diagnosis and 127 healthy controls. For discrimination between the allelic variants, we have established the genotyping by real-time melting analysis of an unlabeled probe. The most notable finding was related to polymorphism N372H in the BRCA2 gene. Compared with the wild-type genotype (NN), the homozygous variant genotype (HH) was associated with an increased FL risk (OR = 2.91, 95% CI: 0.96–8.81), although on the borderline of statistical significance (P = 0.050). However, after stratification by gender and age, the FL risk was significantly increased in men with variant-containing genotypes (OR = 2.79, 95% CI: 1.20–6.45) and even severalfold significantly increased among men with homozygous variant BRCA2 genotype (OR = 21.18, 95% CI: 2.46–182.2). No significant associations with FL risk were identified for other polymorphisms.

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Acknowledgment

The study was supported by the grant VEGA 1/0864/08 of the Ministry of Education of Slovak Republic (75%) and the project “Network of Excellent Laboratories for Oncology,” Operational Program Research and Development financed by European Fund for Regional Development. SEPO, Contract No: 007/2009/2.1/(25%).

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Authors and Affiliations

  1. Department of Medical Biology, School of Medicine, University of P. J. Šafárik, Tr. SNP 1, 040 11, Košice, Slovakia

    Ján Šalagovič & Lucia Klimčáková

  2. Department of Genetics, National Cancer Institute, Klenová 1, 833 10, Bratislava, Slovakia

    Denisa Ilenčíková

  3. Clinic of Haematology and Oncohematology, University of P. J. Šafárik, School of Medicine and L. Pasteur University Hospital, Tr. SNP 1, 040 11, Košice, Slovakia

    Adriana Kafková

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  1. Ján Šalagovič
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  2. Lucia Klimčáková
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Correspondence to Lucia Klimčáková.

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Šalagovič, J., Klimčáková, L., Ilenčíková, D. et al. Association of follicular lymphoma risk with BRCA2 N372H Polymorphism in Slovak population. Med Oncol 29, 1173–1178 (2012). https://doi.org/10.1007/s12032-011-9925-9

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  • DOI: https://doi.org/10.1007/s12032-011-9925-9

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