Skip to main content

Advertisement

SpringerLink
Log in

An Extraordinary Case of Mesenchymal Chondrosarcoma Metastasis in the Thyroid

  • Published:
Endocrine Pathology Aims and scope Submit manuscript

Abstract

Secondary tumours of the thyroid gland account for 1.25 to 3 % in clinical series and reach 24 % in autopsy series. Chondrosarcoma is a rare malignant mesenchymal tumour of chondrogenic nature; the mesenchymal variant represents less than 3 % of all chondrosarcomas, being therefore extremely rare. A mesenchymal chondrosarcoma metastasis in the thyroid is exceptional; to our knowledge, only three previous cases of chondrosarcoma metastasis in the thyroid have been reported to date but none of such cases corresponded to a mesenchymal chondrosarcoma. We present the first of such a case in a 27-year-old woman with a 4-year history of mesenchymal chondrosarcoma of the sacrum that was treated by surgery and chemotherapy. At the present admission, head and neck computed tomography revealed a well-defined nodule in the thyroid gland. The diagnosis of metastasis from the mesenchymal chondrosarcoma was made in the right lobectomy specimen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Gerges AS, Shehata SR, Gouda IA (2006) Metastasis to the thyroid gland: unusual site of metastasis. J Egypt Natl Canc Inst 18:67–72.

    CAS  PubMed  Google Scholar 

  2. DeLellis R (2004) Secondary tumours of the thyroid. In: DeLellis R, Lloyd R, Heitz P, Eng C (eds) Pathology and Genetics of Tumours of Endocrine Organs. IARC, pp 122–123.

  3. Coca-Pelaz A, Rodrigo JP, Triantafyllou A, Hunt JL, Fernández-Miranda JC, Strojan P, de Bree R, Rinaldo A, Takes RP, Ferlito A (2013) Chondrosarcomas of the head and neck. Eur Arch Otorhinolaryngol 271:2601–2609.

    PubMed  Google Scholar 

  4. Giorgadze T, Ward RM, Baloch ZW, LiVolsi VA (2002) Phyllodes tumor metastatic to thyroid Hürthle cell adenoma. Arch Pathol Lab Med 126:1233–1236.

    PubMed  Google Scholar 

  5. Youssef D, Mohamed MT, Mehdi C, Karim N, Mostapha B, Haddou A, Brahim B (2014) Chondrosarcoma metastasis in the thyroid gland: a case report. Journal of Medical Case Reports 8:157.

    Article  Google Scholar 

  6. El Otmany A, Hafid H, Hamada H, El Hafed A, Souadka A, Amrani L, Jahid M, Belabbas M (2001) Métastase intrathyroïdienne d’un chondrosarcome. Médecine Du Maghreb 87:53–54.

    Google Scholar 

  7. Bakx PA, van den Ingh HF, Baggen RG, Veen HF, Oosterhuis WJ (1993) An unusual metastasis of a chondrosarcoma in the thyroid gland. Eur J Surg 159:643–644.

    CAS  PubMed  Google Scholar 

  8. Chung AY, Tran TB, Brumund KT, Weisman RA, Bouvet M (2012) Metastases to the thyroid: a review of the literature from the last decade. Thyroid 22:258–268.

    Article  PubMed  Google Scholar 

  9. Ishikawa M, Hirano S, Tsuji T, Ito J (2011) Management of metastasis to the thyroid gland. Auris Nasus Larynx 38:426–430.

    Article  PubMed  Google Scholar 

  10. Nakashima Y, de Pinieux G, Ladanyi M (2013) Mesenchymal chondrosarcoma. In: Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F (eds) WHO Classification of Tumours of Soft Tissue and Bone. IARC, pp 271–272.

  11. Oliveira AM (2013) Cartilaginous and Osseous Soft Tissue Tumors. In: Hornick JL (ed) Practical Soft Tissue Pathology A Diagnostic Approach. Elsevier, pp 380–381.

  12. Gupta P, Bhalla AS, Karthikeyan V, Bhutia O (2012) Two rare cases of craniofacial chondrosarcoma. World J Radiol 4:283–285.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Prado FO, Nishimoto IN, Perez DE, Kowalski LP, Lopes MA (2009) Head and neck chondrosarcoma: analysis of 16 cases. Br J Oral Maxillofac Surg 47:555–557.

    Article  PubMed  Google Scholar 

  14. Haeri H, Asadi Amoli F, Shariat Torbaghan S (1999) A case report of well differentiated chondrosarcoma of thyroid gland. Acta Medica Iranica 37:249–251.

    Google Scholar 

  15. Wang L, Motoi T, Khanin R, et al. (2012) Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data. Genes Chromosomes Cancer 51:127–139.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  16. Gholamreza M, Ali H, Hossein A, Farzane H, Reza Basirat N, Nushin A, Mehdi E, Saleh J (2013) A rare case of laryngotracheal chondrosarcoma in a patient with past history of radioiodine therapy for thyroid cancer. Adv Biomed Res 2:74.

    Article  Google Scholar 

  17. Pontes HA, Pontes FS, de Abreu MC, de Carvalho PL, de Brito Kato AM, Fonseca FP, de Freitas Silva BS, Neto NC (2012) Clinicopathological analysis of head and neck chondrosarcoma: three case reports and literature review. Int J Oral Maxillofac Surg 41:203–210.

    Article  CAS  PubMed  Google Scholar 

  18. Vankalakunti M, Kaur J, Srinivasan R (2008) Cytology of sarcoma metastasizing to the thyroid: a case report. Acta Cytol 52:729–32.

    Article  PubMed  Google Scholar 

  19. Gattuso P, Castelli MJ, Reyes CV (1989) Fine needle aspiration cytology of metastatic sarcoma involving the thyroid. Southern Medical Journal 82:1158–60.

    Article  CAS  PubMed  Google Scholar 

  20. Haugen BR, Nawaz S, Cohn A, Shroyer K, Bunn PA Jr, Liechty DR, Ridgway EC (1994) Secondary malignancy of the thyroid gland: a case report and review of the literature. Thyroid 4:297–300.

    Article  CAS  PubMed  Google Scholar 

  21. Ackerman L, Romyn A, Khedkar N, Kaplan E (1987) Malignant fibrous histiocytoma metastatic to the thyroid gland. Clin Nucl Med 12:648–9.

    Article  CAS  PubMed  Google Scholar 

  22. Akimov OV (1994) Malignant fibrous histiocytoma of the heart with metastases to the brain and thyroid gland. Arkh Patol 56:70–2.

    CAS  PubMed  Google Scholar 

  23. Kreze A Jr, Zápotocká A, Urbanec T, Koskuba J, Pura M, Vítek P, Praženica P, Traboulsi E (2012) Metastasis of dermatofibrosarcoma from the abdominal wall to the thyroid gland: case report. Case Rep Med 2012:654–9.

    Google Scholar 

  24. Socrier Y, D’Aure D, Lacoste-Collin L, Escourrou G, Soule-Tholy M, Delisle MB, Courtade-Saïdi M (2013) Cytology of a thyroid metastasis from an endometrial sarcoma: a case report. Cytopathology 24:408–9.

    Article  CAS  PubMed  Google Scholar 

  25. Mete O, Ozbey N, Erbil Y, Salmasloglu A, Aral F, Temel B, Dizdaroglu F (2007) Thyroid metastasis of endometrial carcinosarcoma associated with Graves’ disease. Gynecol Endocrinol 23:562–6.

    Article  CAS  PubMed  Google Scholar 

  26. Giannikaki E, Mantadakis E, Mamalaki E, Delides G, Samonis G (2006) Metastatic uterine leiomyosarcoma coexisting with papillary carcinoma of the thyroid gland. Int J Gynecol Cancer 16:442–5.

    Article  CAS  PubMed  Google Scholar 

  27. Michelow PM, Leiman G (1995) Metastases to the thyroid gland: diagnosis by aspiration cytology. Diagn Cytopathol 13:209–13.

    Article  CAS  PubMed  Google Scholar 

  28. Leath CA 3rd, Huh WK, Straughn JM Jr, Conner MG (2002) Uterine leiomyosarcoma metastatic to the thyroid. Obstet Gynecol 100:1122–4.

    Article  PubMed  Google Scholar 

  29. Nemenqani D, Yaqoob N, Khoja H (2010) Leiomyosarcoma metastatic to the thyroid diagnosed by fine needle aspiration cytology. Journal of the Pakistan Medical Association 60:307–9.

    PubMed  Google Scholar 

  30. Wang TY, Lee CH, Yang AH, P’eng FK, Lui WY (1998) Metastatic leiomyosarcoma of the thyroid: a case report. Zhonghua Yi Xue Za Zhi 61:353–7.

    CAS  PubMed  Google Scholar 

  31. Woo Young K, Young Ran K, Sang Uk W, Jae Bok L (2011) Pulmonary leiomyosarcoma metastatic to the thyroid gland: case report and review of the literature. Ann Endocrinol 72:314–6.

    Article  CAS  Google Scholar 

  32. Deng XR, Wang G, Kuang CJ, Peng GZ, Chen RS (2005) Metastasis of leiomyosarcoma to the thyroid. Chinese Medical Journal 118:174–6.

    PubMed  Google Scholar 

  33. Bode-Lesniewska B, Schroder S, Gemsenjager E, Staubli M, Pfaltz M (1994) Leiomyosarcoma in the thyroid gland—primary or metastatic tumour?. Pathologe 15:303–7.

    Article  CAS  PubMed  Google Scholar 

  34. D’Andrea N, Romano V, Mattioli F, Candia S, Montanari A, Guidi L, Carvalho M, Sanguinetti CM (2003) Pulmonary artery leiomyosarcoma with thyroid metastases. Monaldi Arch Chest Dis 59:304–7.

    PubMed  Google Scholar 

  35. Choi YM Jang EK, Ahn SH, Jeon MJ, Han JM, Kim SC, Han DJ, Gong G, Kim TY, Shong YK, Kim WB (2013) Long-term survival of a patient with pulmonary artery intimal sarcoma after sequential metastasectomies of the thyroid and adrenal glands. Endocrinol Metab 28:46–9.

    Article  Google Scholar 

  36. Fulciniti F, Di Mattia D, Bove P, Mastro AA, De Chiara A, Botti G, Petrillo A, Apice G (2008) Fine needle aspiration of metastatic epithelioid angiosarcoma: a report of 2 cases. Acta Cytol 52:612–8.

    Article  PubMed  Google Scholar 

  37. Eng SP, Goh CH, Khoo JB, Yang TL, Lim LH (2005) Metastatic angiosarcoma to the thyroid. Rev Laryngol Otol Rhinol 126:111–4.

    CAS  Google Scholar 

  38. Hafez MT, Hegazy MA, Abd Elwahab K, Arafa M, Abdou I, Refky B (2012) Metastatic rhabdomyosarcoma of the thyroid gland, a case report. Head Neck Oncol 4:27.

    Article  PubMed Central  PubMed  Google Scholar 

  39. Tysome JR, Sandison A, Clarke PM. (2006) Myxoid liposarcoma metastatic to the thyroid gland: a case report and literature review. J Laringol Otol 120:511–3.

    CAS  Google Scholar 

  40. Brandwein-Gensler M, Urken M, Wang B (2004) Collision tumor of the thyroid: a case report of metastatic liposarcoma plus papillary thyroid carcinoma. Head Neck 26:637–41.

    Article  PubMed  Google Scholar 

  41. Azar AR, Weynand B, Daumerie C, Coche E (2003) Metastatic liposarcoma of the thyroid gland. Br J Radiol 76:750–2.

    Article  CAS  PubMed  Google Scholar 

  42. Bashir H, Nawaz MK, Shah MA, Ahmad E (2002) Pleomorphic liposarcoma metastatic to the thyroid gland. Clin Nucl Med 27:9–10.

    Article  PubMed  Google Scholar 

  43. Lam KY, Lo CY (1998) Metastatic tumors of the thyroid gland: a study of 79 cases in Chinese patients. Arch Pathol Lab Med 122:37–41.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centro Hospitalar Lisboa Norte, EPE—Hospital de Santa Maria, Lisbon, Portugal

    Santiago Ortiz & Francisco Tortosa

  2. Ipatimup, Porto, Portugal

    Manuel Sobrinho Simões

Authors
  1. Santiago Ortiz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Francisco Tortosa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Manuel Sobrinho Simões
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Santiago Ortiz.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ortiz, S., Tortosa, F. & Sobrinho Simões, M. An Extraordinary Case of Mesenchymal Chondrosarcoma Metastasis in the Thyroid. Endocr Pathol 26, 33–36 (2015). https://doi.org/10.1007/s12022-014-9351-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12022-014-9351-6

Keywords

Search

Navigation