Abstract
This study aimed to compare the changes and determine the clinical significance of carbohydrate antigens CA242, CA199, CA125, carcinoembryonic antigen (CEA), and tumor-specific growth factor (TSGF) before and after cryoablation by Cryocare system. Thirty-one pancreatic cancer patients were selected to receive cryoablation by Cryocare system. The serum expression levels of CA242, CA199, CA125, CEA, and TSGF before and 1 month after treatment were determined. Meanwhile, the serum level of these factors was also determined in 31 healthy volunteers. The parameter changes were analyzed with the clinical pathological data. The serum levels of CA242, CA199, CA125, CEA, and TSGF in the pancreatic cancer group were significantly higher than those of the control group both before and after the cryoablation treatment (P < 0.05). The serum CA199, CEA, and TSGF dramatically decreased 1 month after the treatment, which were statistically different (P < 0.05). The positive rates of serum CA242, CA199, CA125, and CEA in the pancreatic cancer group were much higher than those in the control group both before and after treatment (P < 0.05), and the positive rate of TSGF was significantly higher than that of the control group before the treatment (P < 0.05). The positive rate of CA199, CEA, and TSGF after the treatment was significantly lower than that before the treatment (P < 0.05). Serum level of CA242 was correlated with the tumor diameter, clinical staging, tumor differentiation, lymph node, and liver metastasis (P < 0.05). Except gender, CA199 was correlated with all the other clinical pathological parameters (P < 0.05). The serum levels of CA125 and CEA were correlated with all the other clinical pathological parameters (P < 0.05). The serum level of TSGF was only correlated with tumor differentiation (P < 0.05). Cryoablation treatment by Cryocare system can decrease the serum levels of CA199, CEA, TSGF, and the positive rate. Serum CA199, CEA, and TSGF can be important index for pancreatic cancer treatment assessment. Serum levels of CA242, CA199, CA125, and CEA are of great clinical value for metastasis assessment and prognosis in pancreatic cancer patients.
Similar content being viewed by others
References
Jelski, W., Kutylowska, E., Laniewska-Dunaj, M., et al. (2011). Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as candidates for tumor markers in patients with pancreatic cancer. Journal of Gastrointestinal and Liver Diseases, 20(3), 255–259.
Gui, J. C., Yan, W. L., & Liu, X. D. (2014). CA19-9 and CA242 as tumor markers for the diagnosis of pancreatic cancer: A meta-analysis. Clinical and Experimental Medicine, 14(2), 225–233.
Liu, H. M., Zhao, S. L., Qu, L. X., et al. (2011). Value of contrast-enhanced ultrasound imaging in monitoring malignant tumor during argon–helium cryosurgery. Nan Fang Yi Ke Da Xue Xue Bao, 31(9), 1622–1625.
Zhou, G., Niu, L., Chiu, D., et al. (2012). Changes in the expression of serum markers CA242, CA199, CA125, CEA, TNF-alpha and TSGF after cryosurgery in pancreatic cancer patients. Biotechnology Letters, 34(7), 1235–1241.
Wang, Z., & Tian, Y. P. (2014). Clinical value of serum tumor markers CA19-9, CA125 and CA72-4 in the diagnosis of pancreatic carcinoma. Molecular and Clinical Oncology, 2(2), 265–268.
Huang, Z., & Liu, F. (2014). Diagnostic value of serum carbohydrate antigen 19-9 in pancreatic cancer: A meta-analysis. Tumour Biology, 35(8), 7459–7465.
Bao, B., Ali, S., Ahmad, A., et al. (2014). Differentially expressed miRNAs in cancer-stem-like cells: Markers for tumor cell aggressiveness of pancreatic cancer. Stem Cells and Development, 23(16), 1947–1958.
Yoo, T., Lee, W. J., Woo, S. M., et al. (2011). Pretreatment carbohydrate antigen 19-9 level indicates tumor response, early distant metastasis, overall survival, and therapeutic selection in localized and unresectable pancreatic cancer. International Journal of Radiation Oncology Biology Physics, 81(4), e623–e630.
Vainshtein, J. M., Schipper, M., Zalupski, M. M., et al. (2013). Prognostic significance of carbohydrate antigen 19-9 in unresectable locally advanced pancreatic cancer treated with dose-escalated intensity modulated radiation therapy and concurrent full-dose gemcitabine: Analysis of a prospective phase 1/2 dose escalation study. International Journal of Radiation Oncology Biology Physics, 86(1), 96–101.
Zhao, J. G., Hu, Y., Liao, Q., et al. (2014). Prognostic significance of SUVmax and serum carbohydrate antigen 19-9 in pancreatic cancer. World Journal of Gastroenterology, 20(19), 5875–5880.
Satoi, S., Yanagimoto, H., Toyokawa, H., et al. (2011). Selective use of staging laparoscopy based on carbohydrate antigen 19-9 level and tumor size in patients with radiographically defined potentially or borderline resectable pancreatic cancer. Pancreas, 40(3), 426–432.
Kanda, M., Fujii, T., Takami, H., et al. (2014). The combination of the serum carbohydrate antigen 19-9 and carcinoembryonic antigen is a simple and accurate predictor of mortality in pancreatic cancer patients. Surgery Today, 44(9), 1692–1701.
Tzeng, C. W., Balachandran, A., Ahmad, M., et al. (2014). Serum carbohydrate antigen 19-9 represents a marker of response to neoadjuvant therapy in patients with borderline resectable pancreatic cancer. HPB (Oxford), 16(5), 430–438.
Li, X., Guo, X., Li, H., et al. (2014). Serum carbohydrate antigen 242 expression exerts crucial function in the diagnosis of pancreatic cancer. Tumour Biology, 35(6), 5281–5286.
Singh, S., Tang, S. J., Sreenarasimhaiah, J., et al. (2011). The clinical utility and limitations of serum carbohydrate antigen (CA19-9) as a diagnostic tool for pancreatic cancer and cholangiocarcinoma. Digestive Diseases and Sciences, 56(8), 2491–2496.
Singh, S., Tang, S. J., Sreenarasimhaiah, J., et al. (2011). The clinical utility and limitations of serum carbohydrate antigen (CA19-9) as a diagnostic tool for pancreatic cancer and cholangiocarcinoma. Digestive Diseases and Sciences, 56(8), 2491–2496.
Liu, H. M., Zhao, S. L., Qu, L. X., et al. (2011). Value of contrast-enhanced ultrasound imaging in monitoring malignant tumor during argon–helium cryosurgery. Nan Fang Yi Ke Da Xue Xue Bao, 31(9), 1622–1625.
Bauer, T. M., El-Rayes, B. F., Li, X., et al. (2013). Carbohydrate antigen 19-9 is a prognostic and predictive biomarker in patients with advanced pancreatic cancer who receive gemcitabine-containing chemotherapy: A pooled analysis of 6 prospective trials. Cancer, 119(2), 285–292.
Pelzer, U., Hilbig, A., Sinn, M., et al. (2013). Value of carbohydrate antigen 19-9 in predicting response and therapy control in patients with metastatic pancreatic cancer undergoing first-line therapy. Frontiers in Oncology, 3, 155.
Kaur, S., Baine, M. J., Guha, S., et al. (2013). Neutrophil gelatinase-associated lipocalin, macrophage inhibitory cytokine 1, and carbohydrate antigen 19-9 in pancreatic juice: Pathobiologic implications in diagnosing benign and malignant disease of the pancreas. Pancreas, 42(3), 494–501.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Chen, Y., Gao, SG., Chen, JM. et al. Serum CA242, CA199, CA125, CEA, and TSGF are Biomarkers for the Efficacy and Prognosis of Cryoablation in Pancreatic Cancer Patients. Cell Biochem Biophys 71, 1287–1291 (2015). https://doi.org/10.1007/s12013-014-0345-2
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12013-014-0345-2