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Short-term Administration of Water-soluble Silicon Improves Mineral Density of the Femur and Tibia in Ovariectomized Rats

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Abstract

Silicon is important for the proper growth and development of bone and connective tissues. This study was designed to investigate if water-soluble silicon could be used for the treatment of postmenopausal osteoporosis. Silicon (Si 20 mg/kg body weight/day) was administrated orally to 17-week-old ovariectomized (OVX) rats for 4 weeks. Silicon did not alter weight gain in OVX rats. Silicon supplementation significantly increased the bone mineral density of the femur (p < 0.05, vs. OVX control group) and tibia in OVX rats (p < 0.05, vs. OVX control group). Serum alkaline phosphatase and osteocalcin, two bone formation biomarkers tested, were not significantly altered, but urinary calcium and phosphorous excretion tended to decrease with silicon supplementation. OVX rats with silicon supplementation showed a relatively higher serum CTx compared to the nonsupplemented OVX group (p < 0.01, vs. OVX control group). According to these results, short-term soluble silicon supplementation improved bone mineral density in OVX-induced osteoporosis.

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Acknowledgments

This work was supported by the 2006 Korea Sanhak Foundation Research Funds.

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Authors and Affiliations

  1. Department of Food and Nutrition, Sookmyung Women’s University, Seoul, 140-742, South Korea

    Yun-Jung Bae

  2. Research Center for Biopharmacetical Lead Molecule, Catholic University, Bucheon, 420-743, South Korea

    Jae-Young Kim

  3. Department of Human Nutrition and Food Science, Chungwoon University, Chungnam, 350-701, South Korea

    Mi-Kyeong Choi

  4. Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, 443-749, South Korea

    Yoon-Sok Chung

  5. Department of Food and Nutrition, Kangwon National University, San 253 Gyo-dong, Samcheok-si, Gangwon, 245-711, South Korea

    Mi-Hyun Kim

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  1. Yun-Jung Bae
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  2. Jae-Young Kim
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  3. Mi-Kyeong Choi
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  4. Yoon-Sok Chung
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Correspondence to Mi-Hyun Kim.

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Bae, YJ., Kim, JY., Choi, MK. et al. Short-term Administration of Water-soluble Silicon Improves Mineral Density of the Femur and Tibia in Ovariectomized Rats. Biol Trace Elem Res 124, 157–163 (2008). https://doi.org/10.1007/s12011-008-8138-3

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  • DOI: https://doi.org/10.1007/s12011-008-8138-3

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