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Prognostic Factors for Survival in Patients with Epithelioid Sarcoma: 441 Cases from the SEER Database

  • Original Article
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Clinical Orthopaedics and Related Research®

Abstract

Current stratification of prognosis in patients with epithelioid sarcoma (ES) is based largely on data reported by individual centers with a limited number of patients. We sought to identify the important prognostic parameters using the Surveillance, Epidemiology, and End Results (SEER) database. We identified 441 patients with ES in the database and extracted information regarding patient demographics and clinical characteristics. Kaplan-Meier, log-rank, and Cox regression were used for analysis. Disease-specific survival declined until 100 months after diagnosis after which survival was unrelated to epithelioid sarcoma. The overall incidence of ES during 2005 was 0.041 per 100,000. The reported incidence has increased since 1973, with an annual percentage change of 5.217%. On multivariate analysis, only age younger than 16 years, local stage of disease, or negative nodes and surgical resection of the tumor predicted better disease-specific survival. We observed no increase in survival by comparing decades of diagnosis since 1986. The SEER database shows only age younger than 16 years, negative nodes, or local stage of disease and operability of primary disease independently predict survival in patients with ES.

Level of Evidence: Level II, prognostic study. See Guidelines for Authors for a complete description of levels of evidence.

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Authors and Affiliations

  1. Department of Orthopaedics, University of Miami Miller School of Medicine, University of Miami Hospital, 4th Floor, 1400 NW, 12th Avenue, Miami, FL, 33136, USA

    Muhammad Umar Jawad MD & Sean P. Scully MD, PhD

  2. Department of Surgery, Weill Cornell Medical College, New York, NY, USA

    Jason Extein BS

  3. Ross University School of Medicine, North Brunswick, NJ, USA

    Elijah S. Min BS

Authors
  1. Muhammad Umar Jawad MD
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  2. Jason Extein BS
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  3. Elijah S. Min BS
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  4. Sean P. Scully MD, PhD
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Correspondence to Sean P. Scully MD, PhD.

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Each author certifies that he or she has no commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing arrangements, etc) that might pose a conflict of interest in connection with the submitted article.

Each author certifies that his or her institution has approved or does not require approval for the protocol for this investigation and that all investigations were conducted in conformity with ethical principles of research.

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Jawad, M.U., Extein, J., Min, E.S. et al. Prognostic Factors for Survival in Patients with Epithelioid Sarcoma: 441 Cases from the SEER Database. Clin Orthop Relat Res 467, 2939–2948 (2009). https://doi.org/10.1007/s11999-009-0749-2

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  • DOI: https://doi.org/10.1007/s11999-009-0749-2

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