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Anti-MDA5 Antibody Spectrum in Western World

  • Inflammatory Muscle Disease (R Aggarwal, Section Editor)
  • Published:
Current Rheumatology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Anti-melanoma differentiation-associated gene 5 (anti-MDA5) is a novel and highly specific myositis-associated autoantibody, which defines a unique phenotype among patients with dermatomyositis (DM).

Recent Findings

Anti-MDA5 was originally characterized in Japan in DM patients with hallmark cutaneous features and no proximal muscle weakness and termed clinically amyopathic DM (CADM). Anti-MDA5 has characteristic cutaneous manifestations which include tender palmar papules and cutaneous ulcerations, along with an increased frequency of interstitial lung disease (ILD) that can be rapidly progressive (RPILD) and fatal.

Summary

This review will highlight the clinical significance of anti-MDA5 autoantibodies in Caucasian DM patients.

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Authors and Affiliations

  1. Myositis Center and Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Siamak Moghadam-Kia, Chester V. Oddis & Rohit Aggarwal

  2. VA Pittsburgh Healthcare System, Pittsburgh, PA, USA

    Siamak Moghadam-Kia

Authors
  1. Siamak Moghadam-Kia
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  2. Chester V. Oddis
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  3. Rohit Aggarwal
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Correspondence to Rohit Aggarwal.

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This article is part of the Topical Collection on Inflammatory Muscle Disease

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Moghadam-Kia, S., Oddis, C.V. & Aggarwal, R. Anti-MDA5 Antibody Spectrum in Western World. Curr Rheumatol Rep 20, 78 (2018). https://doi.org/10.1007/s11926-018-0798-1

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  • DOI: https://doi.org/10.1007/s11926-018-0798-1

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