Skip to main content

Advertisement

SpringerLink
Log in

Cancer and Referred Facial Pain

  • Secondary Headache (M Robbins, Section Editor)
  • Published:
Current Pain and Headache Reports Aims and scope Submit manuscript

Abstract

Orofacial pain may be a symptom of diverse types of cancers as a result of local or distant tumor effects. The pain can be presented with the same characteristics as any other orofacial pain disorder, and this should be recognized by the clinician. Orofacial pain also can arise as a consequence of cancer therapy. In the present article, we review the mechanisms of cancer-associated facial pain, its clinical presentation, and cancer therapy associated with orofacial pain.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: •Of importance ••Of major importance

  1. Benoliel R, Epstein J, Eliav E, Jurevic R, Elad S. Orofacial pain in cancer: part I—mechanisms. J Dent Res. 2007;86(6):491–505.

    Article  CAS  PubMed  Google Scholar 

  2. Clark GT, Ram S. Orofacial pain and neurosensory disorders and dysfunction in cancer patients. Dent Clin N Am. 2008;52(1):183–202. doi:10.1016/j.cden.2007.09.003.

    Article  PubMed  Google Scholar 

  3. Scott-Warren J, Bhaskar A. Cancer pain management—part I: general principles. Continuing education in anaesthesia. Crit Care Pain. 2014. doi:10.1093/bjaceaccp/mkt070. Analgesic ladder for pain control.

    Google Scholar 

  4. Caraceni A, Portenoy RK. An international survey of cancer pain characteristics and syndromes. IASP Task Force on Cancer Pain. International Association for the Study of Pain. Pain. 1999;82(3):263–74.

    Article  CAS  PubMed  Google Scholar 

  5. Fischer DJ, Klasser GD, Epstein JB. Cancer and orofacial pain. Oral Maxillofac Surg Clin North Am. 2008;20(2):287–301. doi:10.1016/j.coms.2007.12.011.

    Article  PubMed  Google Scholar 

  6. Qaisi M, Vorrasi J, Lubek J, Ord R. Multiple primary squamous cell carcinomas of the oral cavity. J Oral Maxillofac Surg. 2014;72(8):1511–6. doi:10.1016/j.joms.2014.03.012.

    Article  PubMed  Google Scholar 

  7. Jain M, Mittal S, Gupta DK. Primary intraosseous squamous cell carcinoma arising in odontogenic cysts: an insight in pathogenesis. J Oral Maxillofac Surg. 2013;71(1):e7–14. doi:10.1016/j.joms.2012.08.031.

    Article  PubMed  Google Scholar 

  8. Lam DK, Schmidt BL. Orofacial pain onset predicts transition to head and neck cancer. Pain. 2011;152(5):1206–9. doi:10.1016/j.pain.2011.02.009. Onset of orofacial pain as a predictor for precancer transition to cancer.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Kirby S, Purdy RA. Headaches and brain tumors. Neurol Clin. 2014;32(2):423–32. doi:10.1016/j.ncl.2013.11.006.

    Article  PubMed  Google Scholar 

  10. Mehrkhodavandi N, Green D, Amato R. Toothache caused by trigeminal neuralgia secondary to vestibular schwannoma: a case report. J Endod. 2014;40(10):1691–4. doi:10.1016/j.joen.2014.03.008.

    Article  PubMed  Google Scholar 

  11. Matsuka Y, Fort ET, Merrill RL. Trigeminal neuralgia due to an acoustic neuroma in the cerebellopontine angle. J Orofac pain. 2000;14(2):147–51.

    CAS  PubMed  Google Scholar 

  12. Fischer DJ, Klasser GD, Epstein JB. Cancer and orofacial pain. Oral Maxillofac Surg Clin N Am. 2008;20(2):287–301. doi:10.1016/j.coms.2007.12.011.

    Article  Google Scholar 

  13. Witt C, Borges AC, Klein K, Neumann H-J. Radiographic manifestations of multiple myeloma in the mandible: a retrospective study of 77 patients. J Oral Maxillofac Surg. 1997;55(5):450–3. doi:10.1016/S0278-2391(97)90687-X.

    Article  CAS  PubMed  Google Scholar 

  14. Benson RE, Rodd HD, North S, Loescher AR, Farthing PM, Payne M. Leukaemic infiltration of the mandible in a young girl. Int J Paediatr Dent. 2007;17(2):145–50. doi:10.1111/j.1365-263X.2006.00794.x.

    Article  PubMed  Google Scholar 

  15. Bouzoubaa S, Khazana M, Slimani F, Chekkoury EI, Benyahya I. [Lung cancer reveal by mandibular metastasis: a case at the Centre of Consultation and Dental Treatment Dental of Casablanca (CCDTC)]. Odonto-Stomatol Trop Trop Dent J. 2014;37(145):40–6.

    CAS  Google Scholar 

  16. D’Silva NJ, Summerlin DJ, Cordell KG, Abdelsayed RA, Tomich CE, Hanks CT, et al. Metastatic tumors in the jaws: a retrospective study of 114 cases. J Am Dent Assoc. 2006;137(12):1667–72.

    Article  PubMed  Google Scholar 

  17. Murillo J, Bagan JV, Hens E, Diaz JM, Leopoldo M. Tumors metastasizing to the oral cavity: a study of 16 cases. J Oral Maxillofac Surg. 2013;71(9):1545–51. doi:10.1016/j.joms.2013.03.017.

    Article  PubMed  Google Scholar 

  18. Lawes K, Danford M, Di Palma S. Delayed metastasis to the mandible of esophageal adenocarcinoma. Head Neck Pathol. 2013;7(4):416–20. doi:10.1007/s12105-013-0450-3.

    Article  PubMed Central  PubMed  Google Scholar 

  19. Sarlani E, Schwartz AH, Greenspan JD, Grace EG. Facial pain as first manifestation of lung cancer: a case of lung cancer-related cluster headache and a review of the literature. J Orofacial Pain. 2003;17(3):262–7.

    PubMed  Google Scholar 

  20. Abraham PJ, Capobianco DJ, Cheshire WP. Facial pain as the presenting symptom of lung carcinoma with normal chest radiograph. Headache: J Head Face Pain. 2003;43(5):499–504. doi:10.1046/j.1526-4610.2003.03097.x.

    Article  Google Scholar 

  21. Pembroke CA, Byrne A, Lester JF, Button M. Persistent unilateral facial pain in lung cancer patients with mediastinal nodal involvement. Lung Cancer. 2013;82(1):173–5. doi:10.1016/j.lungcan.2013.06.024.

    Article  PubMed  Google Scholar 

  22. Naphade PS, Keraliya AR. Facial pain in carcinoma colon. Neurol India. 2013;61(5):540–1. doi:10.4103/0028-3886.121945.

    Article  PubMed  Google Scholar 

  23. Binczak M, Navez M, Perrichon C, Blanchard D, Bollet M, Calmels P, et al. Management of somatic pain induced by head-and-neck cancer treatment: definition and assessment. Guidelines of the French Oto-Rhino-Laryngology- Head and Neck Surgery Society (SFORL). Eur Ann Otorhinolaryngol Head Neck Dis. 2014;131(4):243–7. doi:10.1016/j.anorl.2014.07.003.

    Article  CAS  PubMed  Google Scholar 

  24. Clarkson JE, Worthington HV, Furness S, McCabe M, Khalid T, Meyer S. Interventions for treating oral mucositis for patients with cancer receiving treatment. Cochrane Database of Syst Rev. 2010;8, CD001973. doi:10.1002/14651858.CD001973.pub4.

    Google Scholar 

  25. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436–44. doi:10.1038/nature07205.

    Article  CAS  PubMed  Google Scholar 

  26. Mantyh PW. Cancer pain and its impact on diagnosis, survival and quality of life. Nat Rev Neurosci. 2006;7(10):797–809. doi:10.1038/nrn1914.

    Article  CAS  PubMed  Google Scholar 

  27. Roxburgh CS, McMillan DC. Cancer and systemic inflammation: treat the tumour and treat the host. Br J Cancer. 2014;110(6):1409–12. doi:10.1038/bjc.2014.90.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  28. Ye Y, Dang D, Zhang J, Viet CT, Lam DK, Dolan JC, et al. Nerve growth factor links oral cancer progression, pain, and cachexia. Mol Cancer Ther. 2011;10(9):1667–76. doi:10.1158/1535-7163.MCT-11-0123.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  29. Schmidt BL. What pain tells us about cancer. Pain. 2015;156 Suppl 1:S32–4. doi:10.1097/j.pain.0000000000000099. Review for tumor derived mechanism that induce pain.

    Article  PubMed  Google Scholar 

  30. Ye Y, Ono K, Bernabe DG, Viet CT, Pickering V, Dolan JC, et al. Adenosine triphosphate drives head and neck cancer pain through P2X2/3 heterotrimers. Acta Neuropathol Commun. 2014;2:62. doi:10.1186/2051-5960-2-62.

    Article  PubMed Central  PubMed  Google Scholar 

  31. Schmidt BL, Hamamoto DT, Simone DA, Wilcox GL. Mechanism of cancer pain. Mol Interv. 2010;10(3):164–78. doi:10.1124/mi.10.3.7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  32. Mantyh PW. Bone cancer pain: from mechanism to therapy. Curr Opin Support Palliat Care. 2014;8(2):83–90. doi:10.1097/SPC.0000000000000048.

    Article  PubMed Central  PubMed  Google Scholar 

  33. Bapat AA, Hostetter G, Von Hoff DD, Han H. Perineural invasion and associated pain in pancreatic cancer. Nat Rev Cancer. 2011;11(10):695–707. doi:10.1038/nrc3131.

    Article  CAS  PubMed  Google Scholar 

  34. Binmadi NO, Basile JR. Perineural invasion in oral squamous cell carcinoma: a discussion of significance and review of the literature. Oral Oncol. 2011;47(11):1005–10. doi:10.1016/j.oraloncology.2011.08.002.

    Article  PubMed  Google Scholar 

  35. Johnston M, Yu E, Kim J. Perineural invasion and spread in head and neck cancer. Expert Rev Anticancer Ther. 2012;12(3):359–71. doi:10.1586/era.12.9. Review of perineural invasion in head and neck cancer.

    Article  CAS  PubMed  Google Scholar 

  36. Frunza A, Slavescu D, Lascar I. Perineural invasion in head and neck cancers—a review. J Med Life. 2014;7(2):121–3.

    CAS  PubMed Central  PubMed  Google Scholar 

  37. Nemec SF, Herneth AM, Czerny C. Perineural tumor spread in malignant head and neck tumors. Top Magn Reson Imaging: TMRI. 2007;18(6):467–71. doi:10.1097/rmr.0b013e3181645a0d.

    Article  PubMed  Google Scholar 

  38. Millan MJ. The induction of pain: an integrative review. Prog Neurobiol. 1999;57(1):1–164.

    Article  CAS  PubMed  Google Scholar 

  39. Romero-Reyes M, Head C, Cacalano NA, Jewett A. Potent induction of TNF-alpha during interaction of immune effectors with oral tumors as a potential mechanism for the loss of NK cell viability and function. Apoptosis. 2007.

  40. Jewett A, Cacalano NA, Teruel A, Romero M, Rashedi M, Wang M, et al. Inhibition of nuclear factor kappa B (NFkappaB) activity in oral tumor cells prevents depletion of NK cells and increases their functional activation. Cancer Immunol Immunother: CII. 2006;55(9):1052–63.

    Article  CAS  PubMed  Google Scholar 

  41. Magee MS, Snook AE, Marszalowicz GP, Waldman SA. Immunotherapeutic strategies to target prognostic and predictive markers of cancer. Biomark Med. 2013;7(1):23–35. doi:10.2217/bmm.12.110.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  42. Talmi YP, Waller A, Bercovici M, Horowitz Z, Pfeffer MR, Adunski A, et al. Pain experienced by patients with terminal head and neck carcinoma. Cancer. 1997;80(6):1117–23. doi:10.1002/(SICI)1097-0142(19970915)80:6<1117::AID-CNCR15>3.0.CO;2-B.

    Article  CAS  PubMed  Google Scholar 

  43. Boerman RH, Maassen EM, Joosten J, Kaanders HA, Marres HA, van Overbeeke J, et al. Trigeminal neuropathy secondary to perineural invasion of head and neck carcinomas. Neurology. 1999;53(1):213–6.

    Article  CAS  PubMed  Google Scholar 

  44. Bagan J, Sarrion G, Jimenez Y. Oral cancer: clinical features. Oral Oncol. 2010;46(6):414–7. doi:10.1016/j.oraloncology.2010.03.009.

    Article  PubMed  Google Scholar 

  45. Gorsky M, Epstein JB, Oakley C, Le ND, Hay J, Stevenson-Moore P. Carcinoma of the tongue: a case series analysis of clinical presentation, risk factors, staging, and outcome. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 2004;98(5):546–52. doi:10.1016/j.tripleo.2003.12.041.

    Article  Google Scholar 

  46. Cuffari L, Siqueira JTT, Nemr K, Rapaport A. Pain complaint as the first symptom of oral cancer: a descriptive study. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 2006;102(1):56–61. doi:10.1016/j.tripleo.2005.10.041.

    Article  Google Scholar 

  47. Nomura T, Monobe H, Tamaruya N, Kishishita S, Saito K, Miyamoto R, et al. Primary intraosseous squamous cell carcinoma of the jaw: two new cases and review of the literature. Eur Arch Otorhinolaryngol. 2013;270(1):375–9. doi:10.1007/s00405-012-2235-9.

    Article  PubMed  Google Scholar 

  48. Adachi M, Inagaki T, Ehara Y, Azuma M, Kurenuma A, Motohashi M, et al. Primary intraosseous carcinoma arising from an odontogenic cyst: a case report. Oncol Lett. 2014;8(3):1265–8. doi:10.3892/ol.2014.2248.

    PubMed Central  PubMed  Google Scholar 

  49. Huang J-W, Luo H-Y, Li Q, Li T-J. Primary intraosseous squamous cell carcinoma of the jaws. Arch Pathol Lab Med. 2009;133(11):1834–40. doi:10.1043/1543-2165-133.11.1834.

    PubMed  Google Scholar 

  50. Nthumba PM. Osteosarcoma of the jaws: a review of literature and a case report on synchronous multicentric osteosarcomas. World J Surg Oncol. 2012;10:240. doi:10.1186/1477-7819-10-240.

    Article  PubMed Central  PubMed  Google Scholar 

  51. Chittaranjan B, Tejasvi MLA, Babu BB, Geetha P. Intramedullary osteosarcoma of the mandible: a clinicoradiologic perspective. J Clin Imaging Sci. 2014;4 Suppl 2:6. doi:10.4103/2156-7514.148273.

    PubMed Central  PubMed  Google Scholar 

  52. Clark GT, Ram S. Orofacial pain and neurosensory disorders and dysfunction in cancer patients. Dent Clin N Am. 2008;52(1):183–202. doi:10.1016/j.cden.2007.09.003.

    Article  PubMed  Google Scholar 

  53. Kamio Y, Sakai N, Takahashi G, Baba S, Namba H. Nasopharyngeal carcinoma presenting with rapidly progressive severe visual disturbance: a case report. J Med Case Rep. 2014;8(1):361.

    Article  PubMed Central  PubMed  Google Scholar 

  54. Park KA, Oh SY. Nasopharyngeal carcinoma presenting with rapidly progressive severe binocular optic neuropathy and periocular pain in a young man. J Neuro-Ophthalmol: Off J N Am Neuro-Ophthalmol Soc. 2010;30(2):150–2. doi:10.1097/WNO.0b013e3181ce2ce7.

    Article  Google Scholar 

  55. Reiter S, Gavish A, Winocur E, Emodi-Perlman A, Eli I. Nasopharyngeal carcinoma mimicking a temporomandibular disorder: a case report. J Orofac Pain. 2006;20(1):74–81.

    PubMed  Google Scholar 

  56. Mackie AM, Epstein JB, Wu JSY, Stevenson-Moore P. Nasopharyngeal carcinoma: the role of the dentist in assessment, early diagnosis and care before and after cancer therapy. Oral Oncol. 2000;36(5):397–403. doi:10.1016/S1368-8375(00)00034-8.

    Article  CAS  PubMed  Google Scholar 

  57. Gronseth G, Cruccu G, Alksne J, Argoff C, Brainin M, Burchiel K, et al. Practice Parameter: the diagnostic evaluation and treatment of trigeminal neuralgia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the European Federation of Neurological Societies. Neurology. 2008;71(15):1183–90. doi:10.1212/01.wnl.0000326598.83183.04.

    Article  CAS  PubMed  Google Scholar 

  58. Moazzam AA, Habibian M. Patients appearing to dental professionals with orofacial pain arising from intracranial tumors: a literature review. Oral Surgery Oral Med Oral Pathol Oral Radiol. 2012;114(6):749–55. doi:10.1016/j.oooo.2012.06.017.

    Article  Google Scholar 

  59. Kirby S, Purdy RA. Headache and brain tumors. Curr Neurol Neurosci Rep. 2007;7(2):110–6.

    Article  PubMed  Google Scholar 

  60. Nelson S, Taylor LP. Headaches in brain tumor patients: primary or secondary? Headache: J Head Face Pain. 2014;54(4):776–85. doi:10.1111/head.12326.

    Article  Google Scholar 

  61. Sharma BS, Ahmad FU, Chandra PS, Mahapatra AK. Trigeminal schwannomas: experience with 68 cases. J Clin Neurosci. 2008;15(7):738–43. doi:10.1016/j.jocn.2006.09.007.

    Article  PubMed  Google Scholar 

  62. Wanibuchi M, Fukushima T, Zomordi AR, Nonaka Y, Friedman AH. Trigeminal schwannomas: skull base approaches and operative results in 105 patients. Neurosurgery. 2012;70(1 Suppl Operative):132-43; discussion 43-4. doi:10.1227/NEU.0b013e31822efb21.

  63. Perrini P, Rasile F, Leggate J. Trigeminal neuralgia as initial symptom of paramedian tentorial meningioma. Neurol Sci. 2009;30(1):81–3. doi:10.1007/s10072-009-0014-1.

    Article  PubMed  Google Scholar 

  64. Gopalakrishnan CV, Ansari KA, Nair S, Menon G. Long term outcome in surgically treated posterior fossa epidermoids. Clin Neurol Neurosurg. 2014;117(0):93–9. doi:10.1016/j.clineuro.2013.11.025.

    Article  PubMed  Google Scholar 

  65. Saman Y, Whitehead D, Gleeson M. Jugular foramen schwannoma presenting with glossopharyngeal neuralgia syncope syndrome. Jof Laryngol Otol. 2010;124(12):1305–8. doi:10.1017/S0022215110001556.

    Article  CAS  Google Scholar 

  66. Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, Berger R. Metastatic tumours to the oral cavity—pathogenesis and analysis of 673 cases. Oral Oncol. 2008;44(8):743–52. doi:10.1016/j.oraloncology.2007.09.012.

    Article  PubMed  Google Scholar 

  67. Lawes KP, Danford M, Di Palma S. Delayed metastasis to the mandible of esophageal adenocarcinoma. Head Neck Pathol. 2013;7(4):416–20. doi:10.1007/s12105-013-0450-3. Case presentation of metastasis from a distant organ presenting pain in the orofacial region.

    Article  PubMed Central  PubMed  Google Scholar 

  68. Seoane J, Van der Waal I, Van der Waal RIF, Cameselle-Teijeiro J, Antón I, Tardio A, et al. Metastatic tumours to the oral cavity: a survival study with a special focus on gingival metastases. J Clin Periodontol. 2009;36(6):488–92. doi:10.1111/j.1600-051X.2009.01407.x.

    Article  PubMed  Google Scholar 

  69. Besic N, Luznik Z. Choroidal and orbital metastases from thyroid cancer. Thyroid. 2012;23(5):543–51. doi:10.1089/thy.2012.0021.

    Article  Google Scholar 

  70. Kruse ALD, Luebbers H-T, Obwegeser JA, Edelmann L, Graetz KW. Temporomandibular disorders associated with metastases to the temporomandibular joint: a review of the literature and 3 additional cases. Oral Surg Oral Med Oral Pathol Oral Radiondodontol. 2010;110(2):e21–8. doi:10.1016/j.tripleo.2010.02.031. Clinical case report and review of the literature about metastasis from distant organs reflecting pain in the TMJ.

    Article  Google Scholar 

  71. Albayram S, Adaletli I, Selcuk H, Gulsen F, Islak C, Kocer N. Breast cancer metastasis involving pterygopalatine fossa: a cause of trigeminal neuralgia. Headache: J Head Face Pain. 2004;44(9):927–8. doi:10.1111/j.1526-4610.2004.04178_1.x.

    Article  Google Scholar 

  72. Iriarte Soldevilla JI1 UUM, Angulo Cuesta J, Zubiaur Líbano C, Arceo R, Flores Corral N. [Trigeminal neuralgia. First manifestation of adenocarcinoma of the prostate]. Arch Esp Urol. 1993; 46(1):54-6.

  73. Schoenen J, Broux R, Moonen G. Unilateral facial pain as the first symptom of lung cancer: are there diagnostic clues? Cephalalgia. 1992;12(3):178–9. doi:10.1046/j.1468-2982.1992.1203178.x.

    Article  CAS  PubMed  Google Scholar 

  74. Capobianco DJ. Facial pain as a symptom of nonmetastatic lung cancer. Headache: J Head Face Pain. 1995;35(10):581–5. doi:10.1111/j.1526-4610.1995.hed3510581.x.

    Article  CAS  Google Scholar 

  75. Dach F, Oliveira FAA, dos Santos AC, Speciali JG. Trigeminal neuralgia as the sole symptom of pancreatic cancer. Headache: J Head Face Pain. 2013;53(1):165–7. doi:10.1111/j.1526-4610.2012.02246.x. Clinical case report of trigeminal neuralgia as a symptom of a non-metastatic distant tumor.

    Article  Google Scholar 

  76. Bindoff L, Heseltine D. Unilateral facial pain in patients with lung cancer: a referred pain via the vagus? Lancet. 1988;331(8589):812–5. doi:10.1016/S0140-6736(88)91668-6.

    Article  Google Scholar 

  77. Webber B, Webber M, Keinan D. Extranodal large B cell lymphoma of the anterior maxilla. Case report and review of literature. New York State Dental J. 2015;81(1):34–8.

    Google Scholar 

  78. Parihar S, Garg RK, Narain P. Primary extra-nodal non-Hodgkin’s lymphoma of gingiva: a diagnostic dilemma. J Oral and Maxillofac Pathol: JOMFP. 2013;17(2):320. doi:10.4103/0973-029X.119773.

    PubMed Central  PubMed  Google Scholar 

  79. Oranger A, Carbone C, Izzo M, Grano M. Cellular mechanisms of multiple myeloma bone disease. Clin Dev Immunol. 2013;2013:289458. doi:10.1155/2013/289458.

    Article  PubMed Central  PubMed  Google Scholar 

  80. Troeltzsch M, Oduncu F, Mayr D, Ehrenfeld M, Pautke C, Otto S. Root resorption caused by jaw infiltration of multiple myeloma: report of a case and literature review. J Endod. 2014;40(8):1260–4. doi:10.1016/j.joen.2013.12.030.

    Article  PubMed  Google Scholar 

  81. Assaf AT, Jürgens TP, Benecke AW, Riecke B, Blessmann M, Zrnc TA, et al. Numb chin syndrome: a rare and often overlooked symptom. J Oral Facial Pain Headache. 2014;28(1):80–90. doi:10.11607/jop.994. Neuropathy commonly present in systemic cancers.

    Article  PubMed  Google Scholar 

  82. Romo CG, Jain P, Cortes JE. Numb chin syndrome by precursor B acute lymphoblastic leukemia. Am J Hematol. 2014;89(8):860–1. doi:10.1002/ajh.23766.

    Article  PubMed  Google Scholar 

  83. Reddy CG, Mauermann ML, Solomon BM, Ringler MD, Jerath NU, Begna KH, et al. Neuroleukemiosis: an unusual cause of peripheral neuropathy. Leukemia Lymphoma. 2012;53(12):2405–11. doi:10.3109/10428194.2012.691480. Mechanism of numb chin syndrome.

    Article  PubMed  Google Scholar 

  84. Pelosof LC, Gerber DE. Paraneoplastic syndromes: an approach to diagnosis and treatment. Mayo Clin Proc. 2010;85(9):838–54. doi:10.4065/mcp.2010.0099.

    Article  PubMed Central  PubMed  Google Scholar 

  85. Epstein JB, Elad S, Eliav E, Jurevic R, Benoliel R. Orofacial pain in cancer: part II—clinical perspectives and management. J Dent Res. 2007;86(6):506–18.

    Article  CAS  PubMed  Google Scholar 

  86. Demarquay G, Didelot A, Rogemond V, Ryvlin P, Gouttard M, Garassus P, et al. Facial pain as first manifestation of anti-Hu paraneoplastic syndrome. J Headache Pain. 2010;11(4):355–7. doi:10.1007/s10194-010-0212-5.

    Article  PubMed Central  PubMed  Google Scholar 

  87. Carozzi VA, Canta A, Chiorazzi A. Chemotherapy-induced peripheral neuropathy: what do we know about mechanisms? Neuroscience letters. (0). doi:10.1016/j.neulet.2014.10.014.

  88. Connolly I, Zaleon C, Montagnini M. Management of severe neuropathic cancer pain: an illustrative case and review. Am J Hospice Palliat Med. 2013;30(1):83–90. doi:10.1177/1049909112443586.

    Article  Google Scholar 

  89. Steiner F, Evans J, Marsh R, Rigby P, James S, Sutherland K, et al. Mouth opening and trismus in patients undergoing curative treatment for head and neck cancer. Int J Oral Maxillofac Surg. 2015;44(3):292–6. doi:10.1016/j.ijom.2014.12.009. Relevant for TMD as a consequence on cancer therapy.

    Article  CAS  PubMed  Google Scholar 

  90. Jawad H, Hodson NA, Nixon PJ. A review of dental treatment of head and neck cancer patients, before, during and after radiotherapy: part 1. Br Dent J. 2015;218(2):65–8. doi:10.1038/sj.bdj.2015.28.

    Article  CAS  PubMed  Google Scholar 

  91. Jawad H, Hodson NA, Nixon PJ. A review of dental treatment of head and neck cancer patients, before, during and after radiotherapy: part 2. Br Dent J. 2015;218(2):69–74. doi:10.1038/sj.bdj.2015.29.

    Article  CAS  PubMed  Google Scholar 

  92. Campos MI, Campos CN, Aarestrup FM, Aarestrup BJ. Oral mucositis in cancer treatment: natural history, prevention and treatment. Mol Clin Oncol. 2014;2(3):337–40. doi:10.3892/mco.2014.253.

    PubMed Central  PubMed  Google Scholar 

  93. Barrach RH, de Souza MP, da Silva DP, Lopez PS, Montovani JC. Oral changes in individuals undergoing hematopoietic stem cell transplantation. Braz J Otorhinolaryngol. 2015;81(2):141–7. doi:10.1016/j.bjorl.2014.04.004.

    Article  PubMed  Google Scholar 

  94. Barkokebas A, Silva IH, de Andrade SC, Carvalho AA, Gueiros LA, Paiva SM, et al. Impact of oral mucositis on oral-health-related quality of life of patients diagnosed with cancer. J Oral Pathol Med: Off Publ Int Assoc Oral Pathol Am Acad Oral Pathol. 2014. doi:10.1111/jop.12282.

    Google Scholar 

  95. Viet CT, Corby PM, Akinwande A, Schmidt BL. Review of preclinical studies on treatment of mucositis and associated pain. J Dent Res. 2014;93(9):868–75. doi:10.1177/0022034514540174.

    Article  CAS  PubMed  Google Scholar 

  96. Szczesniak MM, Maclean J, Zhang T, Graham PH, Cook IJ. Persistent dysphagia after head and neck radiotherapy: a common and under-reported complication with significant effect on non-cancer-related mortality. Clin Oncol. 2014;26(11):697–703. doi:10.1016/j.clon.2014.08.009. Relevant for morbidity of cancer therapy.

    Article  CAS  Google Scholar 

  97. Sammut L, Ward M, Patel N. Physical activity and quality of life in head and neck cancer survivors: a literature review. Int J Sports Med. 2014;35(9):794–9. doi:10.1055/s-0033-1363984. Review that exposes the challenges that patients with head and neck cancer suffer, decreasing dramatically their quality of life in addition to be unique for this cancer population.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

We would like to thank Dr. Joan Phelan, professor and chair of the Oral and Maxillofacial Pathology, Radiology and Medicine at NYU College of Dentistry for the picture of the adenoid cystic carcinoma of minor salivary gland origin.

Compliance with Ethics Guidelines

ᅟ

Conflict of Interest

Marcela Romero Reyes, Antonia Teruel, and Yi Ye each declare no potential conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Author information

Authors and Affiliations

  1. Orofacial and Head Pain Service, Department of Oral and Maxillofacial Pathology Radiology and Medicine, New York University College of Dentistry, 345 East 24th Street, New York, NY, 10010, USA

    Marcela Romero-Reyes

  2. Herman Ostrow School of Dentistry, University of Southern California, 925 West 34th Street DEN, 4333, Los Angeles, CA, 90089-0641, USA

    Antonia Teruel

  3. Bluestone Center for Clinical Research, New York University College of Dentistry, 421 1st Ave, 1038, New York, NY, 10010, USA

    Yi Ye

  4. Department of Oral & Maxillofacial, Pathology, Radiology & Medicine, New York University College of Dentistry, 345 East 24th Street, New York, NY, 10010, USA

    Marcela Romero-Reyes

Authors
  1. Marcela Romero-Reyes
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Antonia Teruel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yi Ye
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marcela Romero-Reyes.

Additional information

This article is part of the Topical Collection on Secondary Headache

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Romero-Reyes, M., Teruel, A. & Ye, Y. Cancer and Referred Facial Pain. Curr Pain Headache Rep 19, 37 (2015). https://doi.org/10.1007/s11916-015-0512-1

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11916-015-0512-1

Keywords

Search

Navigation