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Overlap of Genetic Susceptibility to Type 1 Diabetes, Type 2 Diabetes, and Latent Autoimmune Diabetes in Adults

  • Genetics (AP Morris, Section Editor)
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Abstract

Despite the notion that there is a degree of commonality to the biological etiology of type 1 diabetes (T1D) and type 2 diabetes (T2D), the lack of overlap in the genetic factors underpinning each of them suggests very distinct mechanisms. A disorder considered to be at the “intersection” of these two diseases is “latent autoimmune diabetes in adults” (LADA). Interestingly, genetic signals from both T1D and T2D are also seen in LADA, including the key HLA and transcription factor 7-like 2 (TCF7L2) loci, but the magnitudes of these effects are more complex than just pointing to LADA as being a simple admixture of T1D and T2D. We review the current status of the understanding of the genetics of LADA and place it in the context of what is known about the genetics of its better-studied “cousins,” T1D and T2D, especially with respect to the myriad of discoveries made over the last decade through genome-wide association studies.

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Conflict of Interest

Kevin J. Basile, Vanessa C. Guy, Stanley Schwartz, and Struan F.A. Grant report grants from the National Institutes of Health during the conduct of the study.

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Authors and Affiliations

  1. Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA

    Kevin J. Basile, Vanessa C. Guy & Struan F. A. Grant

  2. Main Line Health System, Wynnewood, PA, 19104, USA

    Stanley Schwartz

  3. Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    Struan F. A. Grant

  4. Children’s Hospital of Philadelphia Research Institute, 1102D, 3615 Civic Center Blvd., Philadelphia, PA, 19104, USA

    Struan F. A. Grant

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  1. Kevin J. Basile
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  2. Vanessa C. Guy
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Correspondence to Struan F. A. Grant.

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Basile, K.J., Guy, V.C., Schwartz, S. et al. Overlap of Genetic Susceptibility to Type 1 Diabetes, Type 2 Diabetes, and Latent Autoimmune Diabetes in Adults. Curr Diab Rep 14, 550 (2014). https://doi.org/10.1007/s11892-014-0550-9

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