Current Diabetes Reports

, Volume 13, Issue 2, pp 213–222

The Links Between Insulin Resistance, Diabetes, and Cancer

Authors

  • Etan Orgel
    • Jonathan Jaques Children’s Cancer Center, Keck School of MedicineUniversity of Southern California, Miller Children’s Hospital
    • Children’s Hospital Los Angeles, Keck School of MedicineUniversity of Southern California
Pathogenesis of Type 2 Diabetes and Insulin Resistance (RM Watanabe, Section Editor)

DOI: 10.1007/s11892-012-0356-6

Cite this article as:
Orgel, E. & Mittelman, S.D. Curr Diab Rep (2013) 13: 213. doi:10.1007/s11892-012-0356-6

Abstract

The growing epidemic of obesity has resulted in a large increase in multiple related diseases. Recent evidence has strengthened the proposed synergistic relationship between obesity-related insulin resistance (IR) and/or diabetes mellitus (DM) and cancer. Within the past year, many studies have examined this relationship. Although the precise mechanisms and pathways are uncertain, it is becoming clear that hyperinsulinemia and possibly sustained hyperglycemia are important regulators of not only the development of cancer but also of treatment outcome. Further, clinical decision-making regarding the treatment of choice for DM will likely be impacted as we learn more about the non-metabolic effects of the available hyperglycemic agents. In our review, we endeavored to synthesize the recent literature and provide a concise view of the journey from macro-level clinical associations to specific mechanistic relationships being elucidated in cell lines and animal models.

Keywords

ApoptosisCaloric restrictionCancerChemotherapy resistanceGlargineInsulinInsulin resistanceMetabolic syndromeMetforminObesityProliferationDiabetes

Copyright information

© Springer Science+Business Media New York 2012