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Motile Ciliary Disorders in Chronic Airway Inflammatory Diseases: Critical Target for Interventions

  • Rhinosinusitis (J Mullol, Section Editor)
  • Published:
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Abstract

Purpose of Review

Impaired mucociliary clearance has been implicated in chronic upper and lower airway inflammatory diseases (i.e., allergic and non-allergic rhinitis, chronic rhinosinusitis with or without nasal polyps and asthma). How motile ciliary disorders (impaired ciliogenesis, ciliary beating and ultrastructural defects) are implicated in chronic airway inflammatory diseases is not fully understood. Elaboration of the role of motile ciliary disorders may serve as therapeutic targets for improving mucociliary clearance, thereby complementing contemporary disease management.

Recent Findings

We have summarized the manifestations of motile ciliary disorders and addressed the underlying associations with chronic airway inflammatory diseases. A panel of established and novel diagnostic tests and therapeutic interventions are outlined. Physicians should be vigilant in screening for motile ciliary disorders, particularly in patients with co-existing upper and lower airway inflammatory diseases.

Summary

Proper assessment and treatment of motile ciliary disorders may have added value to the management and prevention of chronic airway inflammatory diseases.

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Funding

National Medical Research Council of Singapore (NMRC/CIRG/1458/2016) (to Prof. Wang); Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme 2017 and Pearl River S&T Nova Program of Guangzhou No. 201710010097 (to Dr. Guan); The Major Research Development Program of Shandong Province No. 2016GSF201084 (to Dr. Zi); Changjiang Scholars and Innovative Research Team in University ITR0961, The National Key Technology R&D Program of the 12th National Five-year Development Plan 2012BAI05B01 and National Key Scientific & Technology Support Program: Collaborative innovation of Clinical Research for chronic obstructive pulmonary disease and lung cancer No. 2013BAI09B09 (to Prof. Zhong).

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  1. Drs. Wei-jie Guan, Yang Peng and Xiao-xue Zi contributed equally.

Authors and Affiliations

  1. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, Guangdong, China

    Wei-jie Guan, Yang Peng & Nan-shan Zhong

  2. Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore

    Wei-jie Guan, Yang Peng, Xiao-xue Zi, Kai Sen Tan, Ting-ting He & De Yun Wang

  3. Department of Otolaryngology, The Second Hospital of Shandong University, Jinan, China

    Xiao-xue Zi

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  1. Wei-jie Guan
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W. J. G., Y. P., X. X. Z., K. S. T. and T. T. H. drafted the manuscript; D. Y. W. and N. S. Z. critically revised the manuscript and approved final submission.

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Correspondence to Nan-shan Zhong or De Yun Wang.

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This article is part of the Topical Collection on Rhinosinusitis

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Guan, Wj., Peng, Y., Zi, Xx. et al. Motile Ciliary Disorders in Chronic Airway Inflammatory Diseases: Critical Target for Interventions. Curr Allergy Asthma Rep 18, 48 (2018). https://doi.org/10.1007/s11882-018-0802-x

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