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Biotechnology and food allergy

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Abstract

The production of genetically modified foods for an increasingly informed and selective consumer requires the coordinated activities of both the companies developing the transgenic food and regulatory authorities to ensure that these foods are at least as safe as the traditional foods they are supplementing in the diet. Although the size and complexity of the food sector ensures that no single player can control the process from seed production through farming and processing to final products marketed in a retail outlet, checks and balances are in place to ensure that transgenic foods will provide a convenient, wholesome, tasty, safe, affordable food source. Ultimately, it is the responsibility of companies developing the genetically modified food to provide relevant data to regulatory agencies, such as the US Department of Agriculture, Environmental Protection Agency, and Food and Drug Administration, to confirm that the transgenic product is reasonably safe for the consumer, as zero risk from allergen sensitization is nonexistent.

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References and Recommended Reading

  1. FAO/WHO Joint Consultation on Allergenicity of Foods Derived from Biotechnology, Rome, Proceedings available at: http://www.who.int/fsf/Gmfood/index.htm.2001. This is the official international guide, which focuses on the question of allergenicity of genetically modified foods. The Consultation revised the earlier FAO/WHO decision tree and made recommendations for further research into allergenicity of genetically modified foods.

  2. Stilwell M, van Dyke B: An activist’s handbook on genetically modified organisms and the WTO. 1999. Available at https// www.consumerscouncil.org/policy/handbook799.htm.

  3. Wal JM: Biotechnology and allergic risk. Rev Fr Allergol Immunol Clin 2001, 41:36–41.

    Google Scholar 

  4. Taylor SL, Hefle SL: Will genetically modified food be allergenic? J Allergy Clin Immunol 2001, 107:765–771.

    Article  PubMed  CAS  Google Scholar 

  5. Martens MA: Safety evaluation of genetically modified foods. Int Arch Occup Environ Health 2000, 73(suppl):S14-S18.

    Article  PubMed  Google Scholar 

  6. Vogt DU, Parish M: Food biotechnology in the United States: science, regulation, and issues. [Biotech Knowledge Web site]. 1999. Available at: http://www.biotechknowledge.com. Reference no. 3216. A good review of the basic information concerning the science of food biotechnology in the United States.

  7. Crawley MJ, Brown SL, Hails RS, et al.: Biotechnology: transgenic crops in natural habitats. Nature 2001, 409:682–683.

    Article  PubMed  CAS  Google Scholar 

  8. Redenbaugh K, Hiatt W, Martineau B: Safety Assessment of Genetically Engineered Fruits and Vegetables. A Case Study of the Flavr Savr Tomato. Boca Raton, FL: CRC Press; 1992:267.

    Google Scholar 

  9. Nisio T, Iida S: Mutants having a low content of 16-kDa allergenic protein in rice (Oryza sativa L.). Theor Appl Genet 1993, 86:317–321.

    Google Scholar 

  10. Finnegan J, McEloy P: Transgene inactivation; plants fight back. Biotechnology 1994, 12:888.

    Google Scholar 

  11. Nakamura R, Matsuda T: Rice allergenic protein and molecular-genetic approach for hypoallergenic rice. Biosci Biotechnol Biochem 1996, 60:1215–1221.

    PubMed  CAS  Google Scholar 

  12. Son DY, Scheurer S, Hoffman A, et al.: Pollen-related food allergy: cloning and immunological analysis of isoforms and mutants of Mal d 1, the major apple allergen, and Bet v 1, the major birch pollen allergen. Eur J Nutr 1999, 38:210–215.

    Article  Google Scholar 

  13. Burks AW, Shin D, Cockrell G, et al.: Mapping and mutational analysis of the IgE binding epitopes on Ara h 1, a legume vicilin protein and a major allergen in peanut hypersensitivity. Eur J Biochem 1997, 245:334–339.

    Article  PubMed  CAS  Google Scholar 

  14. Stanley JS, King N, Burks AW, et al.: Identification and mutational analysis of the immunodominant IgE binding epitopes of the major peanut allergen, Ara h 2. Arch Biochem Biophys 1997, 342:244–253.

    Article  PubMed  CAS  Google Scholar 

  15. Ortolani C, Pastorello EA, Scibilia J: How do we develop hypoallergenic foods, and is there a need for them? Allergy 1997, 52:1170–1174.

    Article  PubMed  CAS  Google Scholar 

  16. Carlson GA, Marra MC, Hubbel B: The Economics of First Crop Biotechnologies. Raleigh: North Carolina State University; 1997.

    Google Scholar 

  17. Ye X, Salim A-B, Andreas K, et al.: Engineering the provitamin A (b-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. Science 2000, 287:303–305.

    Article  PubMed  CAS  Google Scholar 

  18. Walmsley AM, Arntzen CJ: Plants for delivery of edible vaccines. Curr Opin Biotechnol 2000, 11:126–129.

    Article  PubMed  CAS  Google Scholar 

  19. Meningaud J-P, Moutel G, Herve C: Ethical acceptability, health policy and biotechnology based foods: is there a third way between the precaution principle and an overly enthusiastic dissemination of GMO? Med Law 2001, 209:133–141. An ethical perspective on health policies offering regulations that will be useful in gauging the risks and benefits of transgenic foods.

    Google Scholar 

  20. Metcalfe DD, Astwood JD, Townsend R, et al.: Assessment of the allergenic potential of foods derived from genetically engineered crop plants. Crit Rev Food Sci Nutr 1996, 36:S165–186.

    Article  PubMed  CAS  Google Scholar 

  21. FAO/WHO Joint Expert Consultation on Biotechnology and Food Safety. Rome, 1996.

  22. Beeven DE, Kemp CF: Safety issues associated with the DNA in animal feed derived from genetically modified crops. A review of scientific and regulatory procedures. Nutr Abstracts Rev B 2000, 70:175–182.

    Google Scholar 

  23. Heyman M, Desjeuz J: Antigenic handling by intestinal epithelial cells. In Antigen Presentation by Intestinal Epithelial Cells. Edited by Kaiserlian D. Heidelberg, Germany: Springer Verlag; 1997:1–6.

    Google Scholar 

  24. Breiteneder H, Ebner C: Molecular and biochemical classification of plant-derived food allergens. J Allergy Clin Immunol 2000, 106:27–36.

    Article  PubMed  CAS  Google Scholar 

  25. Maynard F, Host R, Wal JM: Human IgE binding capacity of tryptic peptides from bovine alpha-lactoglobulin. Int Arch Allergy Immunol 1997, 113:478–488.

    Article  PubMed  CAS  Google Scholar 

  26. Aalberse RC: Structural biology of allergens. J Allergy Clin Immunol 2000, 106:228–238.

    Article  PubMed  CAS  Google Scholar 

  27. Martin D, Chapman M: Prediction of the allergenicity of a molecule. Rev Fr Allergol Immunol Clin 2001, 41:13–160.

    Google Scholar 

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Helm, R.M. Biotechnology and food allergy. Curr Allergy Asthma Rep 2, 55–62 (2002). https://doi.org/10.1007/s11882-002-0040-z

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  • DOI: https://doi.org/10.1007/s11882-002-0040-z

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