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De novo malignancy after lung transplantation in Japan

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General Thoracic and Cardiovascular Surgery Aims and scope Submit manuscript

Abstract

Objective

Lung transplant recipients have an increased de novo cancer risk due to long-term immunosuppression and several oncogenic viral infections. In Japan, to date, there have been no national surveys of the incidence of de novo malignancy after lung transplantation.

Methods

This national survey was conducted by the Japanese Society for Transplantation. The questionnaire was distributed to lung transplant institutions, asking about several clinical factors related to de novo malignancy patients transplanted from 2001 to 2010.

Results

179 cases of lung transplantation were performed by seven institutions in Japan between 2001 and 2010. De novo malignancies occurred in 18 patients (10.1 %). The most common malignancy was a lymphoproliferative malignancy (12 cases, including 1 double de novo cancer after tongue cancer), followed by cervical cancer (4 cases), breast cancer (2 cases), and tongue cancer (1 case). The mean time of occurrence after transplantation was 37.8 (range 4–148) months. Reduction and/or withdrawal of immunosuppression for the treatment of malignancy was seen in 14 cases. Death due to cancer occurred in 6 cases. The overall 5-year survival of 18 patients was 58.9 %. The 5-year survival of post-transplant lymphoproliferative disorder was not significantly different from that of other malignancies (47.6 and 62.5 %, respectively; p = 0.33).

Conclusions

This is the first national survey of the incidence of de novo malignancy after lung transplantation in Japan. The incidence was 10.1 % and post-transplant lymphoproliferative disorder was the most common malignancy.

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Acknowledgments

The authors would like to thank the members of the academic committee of the Japanese Society for Transplantation and the medical doctors who cooperated with this survey.

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Authors and Affiliations

  1. Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Takuro Miyazaki & Takeshi Nagayasu

  2. Department of Organ Transplant Center, Okayama University Graduate School of Medicine, Okayama, Japan

    Takahiro Oto

  3. Department of General Thoracic Surgery, Osaka University, Suita, Japan

    Meinoshin Okumura

  4. Department of Thoracic Surgery, Kyoto University, Kyoto, Japan

    Hiroshi Date

  5. Department of General Thoracic, Breast, and Pediatric Surgery, Fukuoka University, Fukuoka, Japan

    Takeshi Shiraishi

  6. Department of Thoracic Surgery, Tohoku University, Sendai, Japan

    Yoshinori Okada

  7. Department of Thoracic Surgery, Dokkyo Medical University, Mibu, Japan

    Masayuki Chida

  8. Tohoku Pharmaceutical University Hospital, Sendai, Japan

    Takashi Kondo

Authors
  1. Takuro Miyazaki
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  2. Takahiro Oto
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  3. Meinoshin Okumura
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  4. Hiroshi Date
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  5. Takeshi Shiraishi
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  6. Yoshinori Okada
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  7. Masayuki Chida
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  8. Takashi Kondo
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  9. Takeshi Nagayasu
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Corresponding author

Correspondence to Takuro Miyazaki.

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We have no personal conflicts of interest to declare and no outside support was received for this research.

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Miyazaki, T., Oto, T., Okumura, M. et al. De novo malignancy after lung transplantation in Japan. Gen Thorac Cardiovasc Surg 64, 543–548 (2016). https://doi.org/10.1007/s11748-016-0672-x

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  • DOI: https://doi.org/10.1007/s11748-016-0672-x

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