Skip to main content

Advertisement

SpringerLink
Log in

Lung Cancer and Lung Transplantation

  • REVIEW
  • Published:
Current Pulmonology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Lung cancer is a common complication of lung transplantation (LTx). We sought to describe the current state of knowledge of lung cancer in the LTx patient population, ranging from malignant disease identified at the time of transplant to those diagnosed many years after LTx.

Recent Findings

Despite improvements in long-term survival in LTx recipients, the prevalence of lung cancer seems to be increasing over time. Little data exists to describe best practices for screening, reduction of immunosuppression, or treatment of lung cancer in LTx recipients.

Summary

Further data to define risk of lung cancer and optimal screening protocols to be used in LTx recipients is sorely needed. Whether modified immunosuppressive regimens can reduce the risk of cancer development or impact long-term progression-free survival after a cancer diagnosis remains an active area of investigation. Advances in the field of LTx have the potential to lead to transplantation with minimal or no immunosuppression and vastly reduce the burden of malignant disease as a complication.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: •   Of importance •• Of major importance

  1. • Chambers DC, Cherikh WS, Harhay MO, Hayes D, Hsich E, Khush KK, et al. The international thoracic organ transplant registry of the International Society for Heart and Lung Transplantation: thirty-sixth adult lung and heart-lung transplantation Report-2019; Focus theme: Donor and recipient size match. J Heart Lung Transplant. 2019;38(10):1042–55. https://doi.org/10.1016/j.healun.2019.08.001. Most recent update to ISHLT registry data describing short- and long-term outcomes in lung transplant recipients, burden of post-transplant malignancy.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Kozower BD, Meyers BF, Smith MA, De Oliveira NC, Cassivi SD, Guthrie TJ, et al. The impact of the lung allocation score on short-term transplantation outcomes: a multicenter study. J Thorac Cardiovasc Surg. 2008;135(1):166–71. https://doi.org/10.1016/j.jtcvs.2007.08.044.

    Article  PubMed  Google Scholar 

  3. Egan TM, Edwards LB. Effect of the lung allocation score on lung transplantation in the United States. J Heart Lung Transplant. 2016;35(4):433–9. https://doi.org/10.1016/j.healun.2016.01.010.

    Article  PubMed  Google Scholar 

  4. Ranganath NK, Malas J, Phillips KG, Lesko MB, Smith DE, Angel LF, et al. Single and double lung transplantation have equivalent survival for idiopathic pulmonary fibrosis. Ann Thorac Surg. 2020;109(1):211–7. https://doi.org/10.1016/j.athoracsur.2019.06.090.

    Article  PubMed  Google Scholar 

  5. Chauhan D, Karanam AB, Merlo A, Tom Bozzay PA, Zucker MJ, Seethamraju H, et al. Post-transplant survival in idiopathic pulmonary fibrosis patients concurrently listed for single and double lung transplantation. J Heart Lung Transplant. 2016;35(5):657–60. https://doi.org/10.1016/j.healun.2015.12.030.

    Article  PubMed  Google Scholar 

  6. Li D, Liu Y, Wang B. Single versus bilateral lung transplantation in idiopathic pulmonary fibrosis: a systematic review and meta-analysis. PLoS ONE. 2020;15(5):e0233732. https://doi.org/10.1371/journal.pone.0233732.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Gutierrez-Dalmau A, Campistol JM. Immunosuppressive therapy and malignancy in organ transplant recipients: a systematic review. Drugs. 2007;67(8):1167–98. https://doi.org/10.2165/00003495-200767080-00006.

    Article  CAS  PubMed  Google Scholar 

  8. Magruder JT, Crawford TC, Grimm JC, Kim B, Shah AS, Bush EL, et al. Risk factors for de novo malignancy following lung transplantation. Am J Transplant. 2017;17(1):227–38. https://doi.org/10.1111/ajt.13925.

    Article  CAS  PubMed  Google Scholar 

  9. Le Jeune I, Gribbin J, West J, Smith C, Cullinan P, Hubbard R. The incidence of cancer in patients with idiopathic pulmonary fibrosis and sarcoidosis in the UK. Respir Med. 2007;101(12):2534–40. https://doi.org/10.1016/j.rmed.2007.07.012.

    Article  PubMed  Google Scholar 

  10. Young RP, Hopkins RJ, Christmas T, Black PN, Metcalf P, Gamble GD. COPD prevalence is increased in lung cancer, independent of age, sex and smoking history. Eur Respir J. 2009;34(2):380–6. https://doi.org/10.1183/09031936.00144208.

    Article  CAS  PubMed  Google Scholar 

  11. Kwak N, Park CM, Lee J, Park YS, Lee SM, Yim JJ, et al. Lung cancer risk among patients with combined pulmonary fibrosis and emphysema. Respir Med. 2014;108(3):524–30. https://doi.org/10.1016/j.rmed.2013.11.013.

    Article  PubMed  Google Scholar 

  12. Win T, Thomas BA, Lambrou T, Hutton BF, Screaton NJ, Porter JC, et al. Areas of normal pulmonary parenchyma on HRCT exhibit increased FDG PET signal in IPF patients. Eur J Nucl Med Mol Imaging. 2014;41(2):337–42. https://doi.org/10.1007/s00259-013-2514-8.

    Article  PubMed  Google Scholar 

  13. Umeda Y, Demura Y, Morikawa M, Anzai M, Kadowaki M, Ameshima S, et al. Prognostic value of dual-time-point 18F-FDG PET for idiopathic pulmonary fibrosis. J Nucl Med. 2015;56(12):1869–75. https://doi.org/10.2967/jnumed.115.163360.

    Article  CAS  PubMed  Google Scholar 

  14. Strollo DC, Dacic S, Ocak I, Pilewski J, Bermudez C, Crespo MM. Malignancies incidentally detected at lung transplantation: radiologic and pathologic features. AJR Am J Roentgenol. 2013;201(1):108–16. https://doi.org/10.2214/AJR.12.9374.

    Article  PubMed  Google Scholar 

  15. Nakajima T, Cypel M, de Perrot M, Pierre A, Waddell T, Singer L, et al. Retrospective analysis of lung transplant recipients found to have unexpected lung cancer in explanted lungs. Semin Thorac Cardiovasc Surg. 2015;27(1):9–14. https://doi.org/10.1053/j.semtcvs.2015.02.006.

    Article  PubMed  Google Scholar 

  16. Klikovits T, Lambers C, Ghanim B, Dome B, Murakoezy G, Zöchbauer-Müller S, et al. Lung transplantation in patients with incidental early stage lung cancer-institutional experience of a high volume center. Clin Transplant. 2016;30(8):912–7. https://doi.org/10.1111/ctr.12764.

    Article  PubMed  Google Scholar 

  17. Panchabhai TS, Arrossi AV, Patil PD, Bandyopadhyay D, Budev MM, McCurry KR, et al. Unexpected neoplasms in lungs explanted from lung transplant recipients: a single-center experience and review of literature. Transplant Proc. 2018;50(1):234–40. https://doi.org/10.1016/j.transproceed.2017.12.024.

    Article  CAS  PubMed  Google Scholar 

  18. •• Ahmad U, Hakim AH, Tang A, Tong MZ, Bribriesco A, Budev M, et al. Patterns of recurrence and overall survival in incidental lung cancer in explanted lungs. Ann Thorac Surg. 2019;107(3):891–6. https://doi.org/10.1016/j.athoracsur.2018.09.022. Description of stage at diagnosis and outcomes for explant malignancy in large-single center cohort with high rates of disease recurrence (28%) within 2 years following transplant.

    Article  PubMed  Google Scholar 

  19. Grewal AS, Padera RF, Boukedes S, Divo M, Rosas IO, Camp PC, et al. Prevalence and outcome of lung cancer in lung transplant recipients. Respir Med. 2015;109(3):427–33. https://doi.org/10.1016/j.rmed.2014.12.013.

    Article  PubMed  Google Scholar 

  20. •• Leard LE, Holm AM, Valapour M, Glanville AR, Attawar S, Aversa M, et al. Consensus document for the selection of lung transplant candidates: an update from the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2021;40(11):1349–79. https://doi.org/10.1016/j.healun.2021.07.005. Recently updated guidelines for candidate selection for lung transplantation highlighting considerations when evaluating patients with pre-transplant malignancy.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Tas F, Ciftci R, Kilic L, Karabulut S. Age is a prognostic factor affecting survival in lung cancer patients. Oncol Lett. 2013;6(5):1507–13. https://doi.org/10.3892/ol.2013.1566.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Vadnerkar A, Toyoda Y, Crespo M, Pilewski J, Mitsani D, Kwak EJ, et al. Age-specific complications among lung transplant recipients 60 years and older. J Heart Lung Transplant. 2011;30(3):273–81. https://doi.org/10.1016/j.healun.2010.08.032.

    Article  PubMed  Google Scholar 

  23. Chambers DC, Perch M, Zuckermann A, Cherikh WS, Harhay MO, Hayes D, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-eighth adult lung transplantation report - 2021; Focus on recipient characteristics. J Heart Lung Transplant. 2021;40(10):1060–72. https://doi.org/10.1016/j.healun.2021.07.021.

    Article  PubMed  Google Scholar 

  24. Courtwright A, Cantu E. Lung transplantation in elderly patients. J Thorac Dis. 2017;9(9):3346–51. https://doi.org/10.21037/jtd.2017.08.31.

    Article  PubMed  PubMed Central  Google Scholar 

  25. •• Al-Adra DP, Hammel L, Roberts J, Woodle ES, Levine D, Mandelbrot D, et al. Pretransplant solid organ malignancy and organ transplant candidacy: a consensus expert opinion statement. Am J Transplant. 2021;21(2):460–74. https://doi.org/10.1111/ajt.16318. Consensus statement detailing pre-transplant cancer diagnosis, staging, and recommended disease-free intervals for candidates with prior solid organ tumors.

    Article  PubMed  Google Scholar 

  26. • Al-Adra DP, Hammel L, Roberts J, Woodle ES, Levine D, Mandelbrot D, et al. Preexisting melanoma and hematological malignancies, prognosis, and timing to solid organ transplantation: a consensus expert opinion statement. Am J Transplant. 2021;21(2):475–83. https://doi.org/10.1111/ajt.16324. Consensus statement detailing pre-transplant hematologic malignancy diagnosis, staging, and recommended disease-free intervals for candidates with prior hematologic malignancies or metastatic melanoma.

    Article  PubMed  Google Scholar 

  27. Acuna SA, Lam W, Daly C, Kim SJ, Baxter NN. Cancer evaluation in the assessment of solid organ transplant candidates: a systematic review of clinical practice guidelines. Transplant Rev (Orlando). 2018;32(1):29–35. https://doi.org/10.1016/j.trre.2017.10.002.

    Article  PubMed  Google Scholar 

  28. Paloyan EB, Swinnen LJ, Montoya A, Lonchyna V, Sullivan HJ, Garrity E. Lung transplantation for advanced bronchioloalveolar carcinoma confined to the lungs. Transplantation. 2000;69(11):2446–8. https://doi.org/10.1097/00007890-200006150-00041.

    Article  CAS  PubMed  Google Scholar 

  29. Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, et al. International association for the study of lung cancer/American thoracic society/European respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 2011;6(2):244–85. https://doi.org/10.1097/JTO.0b013e318206a221.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Zorn GL, McGiffin DC, Young KR, Alexander CB, Weill D, Kirklin JK. Pulmonary transplantation for advanced bronchioloalveolar carcinoma. J Thorac Cardiovasc Surg. 2003;125(1):45–8. https://doi.org/10.1067/mtc.2003.72.

    Article  PubMed  Google Scholar 

  31. de Perrot M, Chernenko S, Waddell TK, Shargall Y, Pierre AF, Hutcheon M, et al. Role of lung transplantation in the treatment of bronchogenic carcinomas for patients with end-stage pulmonary disease. J Clin Oncol. 2004;22(21):4351–6. https://doi.org/10.1200/JCO.2004.12.188.

    Article  PubMed  Google Scholar 

  32. Garver RI, Zorn GL, Wu X, McGiffin DC, Young KR, Pinkard NB. Recurrence of bronchioloalveolar carcinoma in transplanted lungs. N Engl J Med. 1999;340(14):1071–4. https://doi.org/10.1056/NEJM199904083401403.

    Article  PubMed  Google Scholar 

  33. Ahmad U, Wang Z, Bryant AS, Kim AW, Kukreja J, Mason DP, et al. Outcomes for lung transplantation for lung cancer in the United Network for Organ Sharing Registry. Ann Thorac Surg. 2012;94(3):935–41. https://doi.org/10.1016/j.athoracsur.2012.04.069.

    Article  PubMed  Google Scholar 

  34. • Triplette M, Crothers K, Mahale P, Yanik EL, Valapour M, Lynch CF, et al. Risk of lung cancer in lung transplant recipients in the United States. Am J Transplant. 2019;19(5):1478–90. https://doi.org/10.1111/ajt.15181. Comparison of the characteristics and outcomes of lung cancer in lung transplant recipents compared with the general population.

    Article  PubMed  Google Scholar 

  35. Schulman LL, Htun T, Staniloae C, McGregor CC, Austin JH. Pulmonary nodules and masses after lung and heart-lung transplantation. J Thorac Imaging. 2000;15(3):173–9. https://doi.org/10.1097/00005382-200007000-00004.

    Article  CAS  PubMed  Google Scholar 

  36. Collins J, Kazerooni EA, Lacomis J, McAdams HP, Leung AN, Shiau M, et al. Bronchogenic carcinoma after lung transplantation: frequency, clinical characteristics, and imaging findings. Radiology. 2002;224(1):131–8. https://doi.org/10.1148/radiol.2241011189.

    Article  PubMed  Google Scholar 

  37. Pérez-Callejo D, Torrente M, Parejo C, Laporta R, Ussetti P, Provencio M. Lung cancer in lung transplantation: incidence and outcome. Postgrad Med J. 2018;94(1107):15–9. https://doi.org/10.1136/postgradmedj-2017-134868.

    Article  PubMed  Google Scholar 

  38. Yserbyt J, Verleden GM, Dupont LJ, Van Raemdonck DE, Dooms C. Bronchial carcinoma after lung transplantation: a single-center experience. J Heart Lung Transplant. 2012;31(6):585–90. https://doi.org/10.1016/j.healun.2012.02.022.

    Article  PubMed  Google Scholar 

  39. • Chambers DC, Zuckermann A, Cherikh WS, Harhay MO, Hayes D, Hsich E, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 37th adult lung transplantation report - 2020; focus on deceased donor characteristics. J Heart Lung Transplant. 2020;39(10):1016–27. https://doi.org/10.1016/j.healun.2020.07.009. Recent ISHLT registry data describing outcomes of transplant of lungs from donors with known cancer risk factors such as tobacco and other recreational substance use, advancing age.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Dickson RP, Davis RD, Rea JB, Palmer SM. High frequency of bronchogenic carcinoma after single-lung transplantation. J Heart Lung Transplant. 2006;25(11):1297–301. https://doi.org/10.1016/j.healun.2006.09.009.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Turner-Warwick M, Lebowitz M, Burrows B, Johnson A. Cryptogenic fibrosing alveolitis and lung cancer. Thorax. 1980;35(7):496–9. https://doi.org/10.1136/thx.35.7.496.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Kataoka T, Okudela K, Matsumura M, Baba T, Kitamura H, Arai H, et al. Significant accumulation of Oncol Lett. 2022;24(1):225. https://doi.org/10.3892/ol.2022.13346.

    Article  CAS  PubMed  Google Scholar 

  43. Furuya Y, Jayarajan SN, Taghavi S, Cordova FC, Patel N, Shiose A, et al. The impact of alemtuzumab and basiliximab induction on patient survival and time to bronchiolitis obliterans syndrome in double lung transplantation recipients. Am J Transplant. 2016;16(8):2334–41. https://doi.org/10.1111/ajt.13739.

    Article  CAS  PubMed  Google Scholar 

  44. Tjon AS, Sint Nicolaas J, Kwekkeboom J, de Man RA, Kazemier G, Tilanus HW, et al. Increased incidence of early de novo cancer in liver graft recipients treated with cyclosporine: an association with C2 monitoring and recipient age. Liver Transpl. 2010;16(7):837–46. https://doi.org/10.1002/lt.22064.

    Article  PubMed  Google Scholar 

  45. Carenco C, Assenat E, Faure S, Duny Y, Danan G, Bismuth M, et al. Tacrolimus and the risk of solid cancers after liver transplant: a dose effect relationship. Am J Transplant. 2015;15(3):678–86. https://doi.org/10.1111/ajt.13018.

    Article  CAS  PubMed  Google Scholar 

  46. O’Neill JO, Edwards LB, Taylor DO. Mycophenolate mofetil and risk of developing malignancy after orthotopic heart transplantation: analysis of the transplant registry of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2006;25(10):1186–91. https://doi.org/10.1016/j.healun.2006.06.010.

    Article  PubMed  Google Scholar 

  47. Reams BD, McAdams HP, Howell DN, Steele MP, Davis RD, Palmer SM. Posttransplant lymphoproliferative disorder: incidence, presentation, and response to treatment in lung transplant recipients. Chest. 2003;124(4):1242–9. https://doi.org/10.1378/chest.124.4.1242.

    Article  PubMed  Google Scholar 

  48. • Dollard SC, Annambhotla P, Wong P, Meneses K, Amin MM, La Hoz RM, et al. Donor-derived human herpesvirus 8 and development of Kaposi sarcoma among 6 recipients of organs from donors with high-risk sexual and substance use behavior. Am J Transplant. 2021;21(2):681–8. https://doi.org/10.1111/ajt.16181. Important publication describing a rare complication of HHV8 infection-associate Kaposi sarcoma in recipients of organs from donors with public health service risk criteria.

    Article  CAS  PubMed  Google Scholar 

  49. Stevens SJ, Verschuuren EA, Pronk I, van Der Bij W, Harmsen MC, The TH, et al. Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of posttransplant lymphoproliferative disease in high-risk patients. Blood. 2001;97(5):1165–71. https://doi.org/10.1182/blood.v97.5.1165.

    Article  CAS  PubMed  Google Scholar 

  50. Bakker NA, Verschuuren EA, Erasmus ME, Hepkema BG, Veeger NJ, Kallenberg CG, et al. Epstein-Barr virus-DNA load monitoring late after lung transplantation: a surrogate marker of the degree of immunosuppression and a safe guide to reduce immunosuppression. Transplantation. 2007;83(4):433–8. https://doi.org/10.1097/01.tp.0000252784.60159.96.

    Article  PubMed  Google Scholar 

  51. • Delaney FT, Murray JG, Hutchinson BD, Egan JJ, Murray M, Winward S, et al. The role of radiology in addressing the challenge of lung cancer after lung transplantation. Eur Radiol. 2022;32(12):8182–90. https://doi.org/10.1007/s00330-022-08942-w. Concise review summarizing broad differential diagnosis for lung nodules in lung transplant recipients and describing radiologic approach to cancer surveillance and diagnosis in transplant recipients.

    Article  PubMed  Google Scholar 

  52. Moore A, Kramer MR, Rosengarten D, Shtraichman O, Zer A, Dudnik E, et al. Stereotactic body radiation therapy (SBRT) for the treatment of primary lung cancer in recipients of lung transplant. Radiol Oncol. 2020;54(2):227–32. https://doi.org/10.2478/raon-2020-0022.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Du L, Pennell NA, Elson P, Hashemi-Sadraei N. Lung cancer treatment outcomes in recipients of lung transplant. Transl Lung Cancer Res. 2015;4(6):784–91. https://doi.org/10.3978/j.issn.2218-6751.2015.12.08.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. • Lashari BH, Vender RJ, Fleitas-Sosa DC, Sinha T, Criner GJ. Lung cancer in recipients after lung transplant: single-centre experience and literature review. BMJ Open Respir Res. 2022;9(1). https://doi.org/10.1136/bmjresp-2021-001194. Single-center analysis of lung transplant recipients diagnosed with lung cancer exploring treatment modalities and outcomes.

  55. Haslam A, Prasad V. Estimation of the percentage of US patients with cancer who are eligible for and respond to checkpoint inhibitor immunotherapy drugs. JAMA Netw Open. 2019;2(5):e192535. https://doi.org/10.1001/jamanetworkopen.2019.2535.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Abdel-Wahab N, Safa H, Abudayyeh A, Johnson DH, Trinh VA, Zobniw CM, et al. Checkpoint inhibitor therapy for cancer in solid organ transplantation recipients: an institutional experience and a systematic review of the literature. J Immunother Cancer. 2019;7(1):106. https://doi.org/10.1186/s40425-019-0585-1.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Kawashima S, Joachim K, Abdelrahim M, Abudayyeh A, Jhaveri KD, Murakami N. Immune checkpoint inhibitors for solid organ transplant recipients: clinical updates. Korean J Transplant. 2022;36(2):82–98. https://doi.org/10.4285/kjt.22.0013.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Tsung I, Worden FP, Fontana RJ. A Pilot study of checkpoint inhibitors in solid organ transplant recipients with metastatic cutaneous squamous cell carcinoma. Oncologist. 2021;26(2):133–8. https://doi.org/10.1002/onco.13539.

    Article  PubMed  Google Scholar 

  59. •• Daud A, Mehra MR, Siu A, Johnson MR, Perch M, Budev M, et al. Immune checkpoint inhibitors in heart or lung transplantation: early results from a registry initiative. J Heart Lung Transplant. 2020;39(6):604–6. https://doi.org/10.1016/j.healun.2020.02.015. Case series of thoracic organ transplant recipients treated with immune checkpoint inhibitors, call to action for greater study on the utility of this class of drugs in transplant recipients.

    Article  PubMed  Google Scholar 

  60. Nair N, Gongora E, Mehra MR. Long-term immunosuppression and malignancy in thoracic transplantation: where is the balance? J Heart Lung Transplant. 2014;33(5):461–7. https://doi.org/10.1016/j.healun.2014.03.002.

    Article  PubMed  Google Scholar 

  61. Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer. 2004;4(5):335–48. https://doi.org/10.1038/nrc1362.

    Article  CAS  PubMed  Google Scholar 

  62. Sodhi A, Chaisuparat R, Hu J, Ramsdell AK, Manning BD, Sausville EA, et al. The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi’s sarcoma-associated herpesvirus G protein-coupled receptor. Cancer Cell. 2006;10(2):133–43. https://doi.org/10.1016/j.ccr.2006.05.026.

    Article  CAS  PubMed  Google Scholar 

  63. de Pablo A, Santos F, Solé A, Borro JM, Cifrian JM, Laporta R, et al. Recommendations on the use of everolimus in lung transplantation. Transplant Rev (Orlando). 2013;27(1):9–16. https://doi.org/10.1016/j.trre.2012.11.001.

    Article  PubMed  Google Scholar 

  64. • Copeland H, Hayanga JWA, Neyrinck A, MacDonald P, Dellgren G, Bertolotti A, et al. Donor heart and lung procurement: a consensus statement. J Heart Lung Transplant. 2020;39(6):501–17. https://doi.org/10.1016/j.healun.2020.03.020. Expert guidelines describing recommended lung transplant donor evaluation.

    Article  PubMed  Google Scholar 

  65. Krist AH, Davidson KW, Mangione CM, Barry MJ, Cabana M, Caughey AB, et al. Screening for lung cancer: US preventive services task force recommendation statement. JAMA. 2021;325(10):962–70. https://doi.org/10.1001/jama.2021.1117.

    Article  PubMed  Google Scholar 

  66. Mohammadi S, Bonnet N, Leprince P, Charbonneau E, Berberian G, Aslani M, et al. Long-term survival of heart transplant recipients with lung cancer: the role of chest computed tomography screening. Thorac Cardiovasc Surg. 2007;55(7):438–41. https://doi.org/10.1055/s-2007-965306.

    Article  CAS  PubMed  Google Scholar 

  67. Finkenstedt A, Graziadei IW, Oberaigner W, Hilbe W, Nachbaur K, Mark W, et al. Extensive surveillance promotes early diagnosis and improved survival of de novo malignancies in liver transplant recipients. Am J Transplant. 2009;9(10):2355–61. https://doi.org/10.1111/j.1600-6143.2009.02766.x.

    Article  PubMed  Google Scholar 

  68. Blanc PD, Annesi-Maesano I, Balmes JR, Cummings KJ, Fishwick D, Miedinger D, et al. The occupational burden of nonmalignant respiratory diseases. An official American Thoracic Society and European Respiratory Society statement. Am J Respir Crit Care Med. 2019;199(11):1312–34. https://doi.org/10.1164/rccm.201904-0717ST.

    Article  PubMed  PubMed Central  Google Scholar 

  69. Mathios D, Johansen JS, Cristiano S, Medina JE, Phallen J, Larsen KR, et al. Detection and characterization of lung cancer using cell-free DNA fragmentomes. Nat Commun. 2021;12(1):5060. https://doi.org/10.1038/s41467-021-24994-w.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. • Chaban R, Cooper DKC, Pierson RN. Pig heart and lung xenotransplantation: present status. J Heart Lung Transplant. 2022;41(8):1014–22. https://doi.org/10.1016/j.healun.2022.04.010. Recent review summarizing current status of porcine xenotransplanation in thoracic organ transplant.

    Article  PubMed  Google Scholar 

  71. Yanagiya M, Kitano K, Yotsumoto T, Asahina H, Nagayama K, Nakajima J. Transplantation of bioengineered lungs created from recipient-derived cells into a large animal model. Semin Thorac Cardiovasc Surg. 2021;33(1):263–71. https://doi.org/10.1053/j.semtcvs.2020.03.005.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, 5841 South Maryland Avenue, MC 6026, Chicago, USA

    Renea Jablonski

Authors
  1. Renea Jablonski
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Renea Jablonski.

Ethics declarations

Conflict of Interest

Renea Jablonski declares that she has no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by the author.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jablonski, R. Lung Cancer and Lung Transplantation. Curr Pulmonol Rep 12, 1–9 (2023). https://doi.org/10.1007/s13665-023-00301-4

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13665-023-00301-4

Keywords

Search

Navigation