An 80-year-old woman presented to the internal medicine department for three episodes of melena for 2 days. She reported taking NSAIDs (ibuprofen 1600 mg daily) the prior week. The physical examination was unremarkable with stable vital signs. Laboratory tests were significant for an iron deficiency anemia with hemoglobin ranging from 9.0 to 11.0 g/dL (reference range 12.5–14.5 g/dL). Her past medical history included osteoarthritis (occasional taking of NSAIDs) and hysterectomy. Esophagogastroduodenoscopy showed a black-appearing esophageal mucosa circumferentially occupying the entire body of the second half of the esophagus (Fig. 1). Biopsies of the lesion demonstrated epithelial cell necrosis, with non-specific inflammatory exudates. The patient gradually recovered after conservative treatments (hydration, intravenous, proton pump inhibitor, sucralfate and total parenteral nutrition). Follow-up upper gastrointestinal endoscopy revealed a remarkable healing of the esophageal wall with no complications (Fig. 2).
‘Black esophagus’ or acute esophageal necrosis (AEN) was first described by Goldenberg et al. in the early 1990s [1, 2]. The incidence of black esophagus is very low, ranging from 0.012 to 0.2 %, and according to the literature, 90 cases have been reported so far [3, 4]. The etiology is unknown in most cases. Most investigators have suggested an ischemic origin. Risk factors include advanced age, male gender, cardiovascular disease, alcoholic ingestion and malnutrition, acute gastric outlet obstruction with gastro-esophageal reflux, diabetes, acute renal failure and trauma. Candidiasis is a rare cause of AEN. An incidental finding in upper endoscopy has also been mentioned [5]. The esophagus has a black-appearing color, with easily crumbled mucosa predominantly affecting the lower two-thirds of the esophagus. Esophageal transit with barium swallow shows if there is any potential of an esophageal motility disorders, and computed tomography (CT scan) may reveal a thickened distal esophagus, a hiatal hernia, and a distended fluid-filled stomach with possible gastric outlet obstruction. Endoscopic biopsies show epithelial necrosis, with non-specific inflammatory exudates, and ulcerations. Esophageal bleeding (melena and hematemesis) is the most common presentation. The differential diagnosis of black esophagus includes: the ingestion of corrosive agents, infections, esophageal melanosis and pseudomelanosis, acanthosis nigricans and coal-dust miner. The main reported complications of AEN are stenosis and strictures. Regarding the therapeutic approach, most authors recommend adequate hydration, the use of a proton pump inhibitor, sucralfate, and treating the esophageal infection, if present. Additionally, treating the patient’s comorbidities such as restoration of the iron adequacy, and elimination of any esophageal infection as well as abstinence from alcohol, which may have been an aggravating factor. The prognosis is usually hopeful if other comorbidities do not influence the outcome.
References
Yamauchi J, Mitsufuji S, Taniguchi J et al (2005) Acute esophageal necrosis followed by upper endoscopy and esophageal manometry/pH test. Dig Dis Sci 50:1718–1721
Yasuda H, Yamada M, Endo Y et al (2006) Acute necrotizing esophagitis: role of nonsteroidal anti-inflammatory drugs. J Gastroenterol 41:193–197
Ben Soussan E, Savoye G, Hochain P et al (2002) Acute esophageal necrosis: 1-year prospective study. Gastrointest Endosc 56:213–217
Moreto M, Ojembarrena E, Zaballa M, Tanago JG, Ibanez S (1993) Idiopathic acute esophageal necrosis: not necessarily a terminal event. Endoscopy 25:534
Ramos R, Mascarenhas J, Duarte P et al (2008) Acute esophageal necrosis: a retrospective case series. Rev Esp Enferm Dig 100:583–585
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Galanopoulos, M., Anastasiadis, S., Archavlis, E. et al. Black esophagus: an uncommon cause of upper gastrointestinal bleeding. Intern Emerg Med 11, 1019–1020 (2016). https://doi.org/10.1007/s11739-015-1360-z
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DOI: https://doi.org/10.1007/s11739-015-1360-z