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Serum SPARC and Matrix Metalloproteinase-2 and Metalloproteinase-9 Concentrations after Bariatric Surgery in Obese Adults

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Abstract

Background

Remodeling of the extracellular matrix (ECM) of adipose tissue is regarded as part of the pathophysiology of obesity. Secreted protein acidic and rich in cysteine (SPARC) was the first ECM protein described in adipose tissue. Matrix metalloproteinases (MMPs) also play a role in ECM remodeling, and MMP-2 and MMP-9 may be associated with abnormal ECM metabolism. Here, we investigated changes in serum SPARC, MMP-2, and MMP-9 concentrations after bariatric surgery in obese adults.

Methods

We recruited 34 obese patients who were scheduled to undergo bariatric surgery for weight loss. We analyzed changes in serum SPARC, MMP-2, and MMP-9 concentrations before and 9 months after bariatric surgery and any associations between changes in SPARC, MMP-2, and MMP-9 concentrations and obesity-related parameters.

Results

Serum leptin levels significantly decreased, and the serum adiponectin level significantly increased after bariatric surgery. The serum SPARC concentration decreased significantly from 165.0 ± 18.2 to 68.7 ± 6.7 ng/mL (p < 0.001), and the MMP-2 concentration also decreased significantly from 262.2 ± 15.2 to 235.9 ± 10.5 ng/mL (p < 0.001). Changes in the serum SPARC concentration were significantly correlated with HOMA-IR changes, and changes in the serum MMP-9 concentration were found to inversely correlate with serum adiponectin changes.

Conclusion

These findings show that significant decreases in serum SPARC and MMP-2 concentrations occur after bariatric surgery. Our results thus suggest that weight loss via bariatric surgery could alter the ECM environment, and that these changes are related to certain metabolic changes.

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Acknowledgments

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) and funded by the Ministry of Education, Science, and Technology (2012–004869) and a grant (2012–106) from the Asian Institute for Life Sciences, Seoul, Korea.

Conflict of Interest

Seoung Hee Lee, Hye Soon Park, Seul Ki Lee, Yeon Jin Jang, Yeon Ji Lee, and Yoon-Suk Heo have no conflicts of interest to declare.

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Authors and Affiliations

  1. Department of Family Medicine, College of Medicine, Inha University, 7-206, Sinheung-dong 3-Ga, Jung-gu, Incheon, 400-711, South Korea

    Yeon Ji Lee

  2. Department of General Surgery, College of Medicine, Inha University, 7-206, Sinheung-dong 3-Ga, Jung-gu, Incheon, 400-711, South Korea

    Yoon-Seok Heo

  3. Department of Family Medicine, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-gu, Seoul, 138-736, South Korea

    Hye Soon Park & Seoung Hee Lee

  4. Department of Physiology, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-gu, Seoul, 138-736, South Korea

    Seul Ki Lee & Yeon Jin Jang

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  1. Yeon Ji Lee
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Correspondence to Yoon-Seok Heo or Hye Soon Park.

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Lee, Y.J., Heo, YS., Park, H.S. et al. Serum SPARC and Matrix Metalloproteinase-2 and Metalloproteinase-9 Concentrations after Bariatric Surgery in Obese Adults. OBES SURG 24, 604–610 (2014). https://doi.org/10.1007/s11695-013-1111-z

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  • DOI: https://doi.org/10.1007/s11695-013-1111-z

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