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Neural basis of individual differences in the response to mental stress: a magnetoencephalography study

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Abstract

Stress is a risk factor for the onset of mental disorders. Although stress response varies across individuals, the mechanism of individual differences remains unclear. Here, we investigated the neural basis of individual differences in response to mental stress using magnetoencephalography (MEG). Twenty healthy male volunteers completed the Temperament and Character Inventory (TCI). The experiment included two types of tasks: a non-stress-inducing task and a stress-inducing task. During these tasks, participants passively viewed non-stress-inducing images and stress-inducing images, respectively, and MEG was recorded. Before and after each task, MEG and electrocardiography were recorded and subjective ratings were obtained. We grouped participants according to Novelty seeking (NS) - tendency to be exploratory, and Harm avoidance (HA) - tendency to be cautious. Participants with high NS and low HA (n = 10) assessed by TCI had a different neural response to stress than those with low NS and high HA (n = 10). Event-related desynchronization (ERD) in the beta frequency band was observed only in participants with high NS and low HA in the brain region extending from Brodmann’s area 31 (including the posterior cingulate cortex and precuneus) from 200 to 350 ms after the onset of picture presentation in the stress-inducing task. Individual variation in personality traits (NS and HA) was associated with the neural response to mental stress. These findings increase our understanding of the psychological and neural basis of individual differences in the stress response, and will contribute to development of the psychotherapeutic approaches to stress-related disorders.

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References

  • Akselrod, S., Gordon, D., Ubel, F. A., Shannon, D. C., Berger, A. C., & Cohen, R. J. (1981). Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science, 213, 220–222.

    Article  CAS  PubMed  Google Scholar 

  • Allison, T., McCarthy, G., Nobre, A., Puce, A., & Belger, A. (1994). Human extrastriate visual cortex and the perception of faces, words, numbers, and colors. Cerebral Cortex, 4, 544–554.

    Article  CAS  PubMed  Google Scholar 

  • Appel, M. L., Berger, R. D., Saul, J. P., Smith, J. M., & Cohen, R. J. (1989). Beat to beat variability in cardiovascular variables: noise or music? Journal of the American College of Cardiology, 14, 1139–1148.

    Article  CAS  PubMed  Google Scholar 

  • Ayduk, O., & Kross, E. (2008). Enhancing the pace of recovery: self-distanced analysis of negative experiences reduces blood pressure reactivity. Psychological Science, 19, 229–231.

    Article  PubMed  Google Scholar 

  • Baeken, C., Van Schuerbeek, P., De Raedt, R., Bossuyt, A., Vanderhasselt, M. A., De Mey, J., & Luypaert, R. (2010). Passively viewing negatively valenced baby faces attenuates left amygdala activity in healthy females scoring high on ‘Harm Avoidance’. Neuroscience Letters, 478, 97–101.

  • Battaglia, M., Przybeck, T. R., Bellodi, L., & Cloninger, C. R. (1996). Temperament dimensions explain the comorbidity of psychiatric disorders. Comprehensive Psychiatry, 37, 292–298.

    Article  CAS  PubMed  Google Scholar 

  • Battaglia, M., Bertella, S., Bajo, S., Politi, E., & Bellodi, L. (1998). An investigation of the co-occurrence of panic and somatization disorders through temperamental variables. Psychosomatic Medicine, 60, 726–729.

    Article  CAS  PubMed  Google Scholar 

  • Becker, J. T., Bajo, R., Fabrizio, M., Sudre, G., Cuesta, P., Aizenstein, H. J., Lopez, O. L., Wolk, D., Parkkonen, L., Maestu, F., & Bagic, A. (2012). Functional connectivity measured with magnetoencephalography identifies persons with HIV disease. Brain Imaging and Behavior, 6, 366–373.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bluhm, R. L., Frewen, P. A., Coupland, N. C., Densmore, M., Schore, A. N., & Lanius, R. A. (2012). Neural correlates of self-reflection in post-traumatic stress disorder. Acta Psychiatrica Scandinavica, 125, 238–246.

    Article  CAS  PubMed  Google Scholar 

  • Cloninger, C. R. (1986). A unified biosocial theory of personality and its role in the development of anxiety states. Psychiatric Developments, 4, 167–226.

    CAS  PubMed  Google Scholar 

  • Cloninger, C. R. (1987). A systematic method for clinical description and classification of personality variants. A Proposal. Archives of General Psychiatry, 44, 573–588.

  • Cloninger, C. R., Svrakic, D. M., & Przybeck, T. R. (1993). A psychobiological model of temperament and character. Archives of General Psychiatry, 50, 975–990.

    Article  CAS  PubMed  Google Scholar 

  • Conrad, R., Wegener, I., Imbierowicz, K., Liedtke, R., & Geiser, F. (2009). Alexithymia, temperament and character as predictors of psychopathology in patients with major depression. Psychiatry Research, 165, 137–144.

    Article  PubMed  Google Scholar 

  • Culham, J. C., & Kanwisher, N. G. (2001). Neuroimaging of cognitive functions in human parietal cortex. Current Opinion in Neurobiology, 11, 157–163.

    Article  CAS  PubMed  Google Scholar 

  • Dalal, S. S., Guggisberg, A. G., Edwards, E., Sekihara, K., Findlay, A. M., Canolty, R. T., Berger, M. S., Knight, R. T., Barbaro, N. M., Kirsch, H. E., & Nagarajan, S. S. (2008). Five-dimensional neuroimaging: localization of the time-frequency dynamics of cortical activity. NeuroImage, 40, 1686–1700.

    Article  PubMed  PubMed Central  Google Scholar 

  • David, O., Kilner, J. M., & Friston, K. J. (2006). Mechanisms of evoked and induced responses in MEG/EEG. NeuroImage, 31, 1580–1591.

    Article  PubMed  Google Scholar 

  • De Fruyt, F., Van de Wiele, L., & Van Heeringen, C. (2000). Cloninger’s psychobiological model of temperament and character and the five-factor model of personality. Personality and Individual Differences, 29, 441–452.

    Article  Google Scholar 

  • Dietrich, S., Deckert, S., Ceynowa, M., Hegerl, U., & Stengler, K. (2012). Depression in the workplace: a systematic review of evidence-based prevention strategies. International Archives of Occupational and Environmental Health, 85, 1–11.

    Article  PubMed  Google Scholar 

  • Ebstein, R. P., Novick, O., Umansky, R., Priel, B., Osher, Y., Blaine, D., Bennett, E. R., Nemanov, L., Katz, M., & Belmaker, R. H. (1996). Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking. Nature Genetics, 12, 78–80.

  • Evans, A. C., Kamber, M., Collins, D. L., & MacDonald, D. (1994). An MRI-based Probalistic Atlas of Neuroanatomy. Magnetic resonance scannning and epilepsy (pp. 263–274). New York: Plenum Press.

    Book  Google Scholar 

  • Faillenot, I., Decety, J., & Jeannerod, M. (1999). Human brain activity related to the perception of spatial features of objects. NeuroImage, 10, 114–124.

    Article  CAS  PubMed  Google Scholar 

  • Friston, K. J., Holmes, A. P., & Worsley, K. J. (1999). How many subjects constitute a study? NeuroImage, 10, 1–5.

    Article  CAS  PubMed  Google Scholar 

  • Gil, S., & Caspi, Y. (2006). Personality traits, coping style, and perceived threat as predictors of posttraumatic stress disorder after exposure to a terrorist attack: a prospective study. Psychosomatic Medicine, 68, 904–909.

    Article  PubMed  Google Scholar 

  • Goldstein, D. S. (2001). The autonomic nervous system in health and disease. New York: Marel Dekker, Inc..

    Google Scholar 

  • Goldstein, D. S., & McEwen, B. (2002). Allostasis, homeostats, and the nature of stress. Stress, 5, 55–58.

    Article  PubMed  Google Scholar 

  • Hakamata, Y., Iwase, M., Kato, T., Senda, K., & Inada, T. (2013). The neural correlates of mindful awareness: a possible buffering effect on anxiety-related reduction in subgenual anterior cingulate cortex activity. PloS One, 8, e75526.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Heim, C., & Nemeroff, C. B. (2002). Neurobiology of early life stress: clinical studies. Seminars in Clinical Neuropsychiatry, 7, 147–159.

    Article  PubMed  Google Scholar 

  • Heponiemi, T., Ravaja, N., Elovainio, M., & Keltikangas-Jarvinen, L. (2007). Relationships between hostility, affective ratings of pictures, and state affects during task-induced stress. Journal of Psychology, 141, 183–201.

    Article  PubMed  Google Scholar 

  • Hillebrand, A., Singh, K. D., Holliday, I. E., Furlong, P. L., & Barnes, G. R. (2005). A new approach to neuroimaging with magnetoencephalography. Human Brain Mapping, 25, 199–211.

    Article  PubMed  Google Scholar 

  • Hirano, S., Sato, T., Narita, T., Kusunoki, K., Ozaki, N., Kimura, S., Takahashi, T., Sakado, K., & Uehara, T. (2002). Evaluating the state dependency of the Temperament and Character Inventory dimensions in patients with major depression: a methodological contribution. Journal of Affective Disorders, 69, 31–38.

  • Izhikevich, E. M., & Edelman, G. M. (2008). Large-scale model of mammalian thalamocortical systems. Proceedings of the National Academy of Sciences of the United States of America, 105, 3593–3598.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Johnson, S. C., Baxter, L. C., Wilder, L. S., Pipe, J. G., Heiserman, J. E., & Prigatano, G. P. (2002). Neural correlates of self-reflection. Brain, 125, 1808–1814.

    Article  PubMed  Google Scholar 

  • Kampman, O., & Poutanen, O. (2011). Can onset and recovery in depression be predicted by temperament? A systematic review and meta-analysis. Journal of Affective Disorders, 135, 20–27.

    Article  PubMed  Google Scholar 

  • Katsuragi, S., Kunugi, H., Sano, A., Tsutsumi, T., Isogawa, K., Nanko, S., & Akiyoshi, J. (1999). Association between serotonin transporter gene polymorphism and anxiety-related traits. Biological Psychiatry, 45, 368–370.

    Article  CAS  PubMed  Google Scholar 

  • Kendler, K. S., Kuhn, J., & Prescott, C. A. (2004). The interrelationship of neuroticism, sex, and stressful life events in the prediction of episodes of major depression. The American Journal of Psychiatry, 161, 631–636.

    Article  PubMed  Google Scholar 

  • Kijima, N., Satio, R., Takeuchi, M., Yoshino, A., Ono, Y., Kato, M., & Kitamura, T. (1996). Cloninger’s seven-factor model of temperament and character and Japanese version of temperament and character inventory (TCI). Japanese Journal of Psychiatric Diagnostics and Clinical Evaluation, 7, 379–399.

  • Kijima, N., Tanaka, E., Suzuki, N., Higuchi, H., & Kitamura, T. (2000). Reliability and validity of the Japanese version of the temperament and character inventory. Psychological Reports, 86, 1050–1058.

    Article  CAS  PubMed  Google Scholar 

  • Kirschbaum, C., & Hellhammer, D. H. (1989). Salivary cortisol in psychobiological research: an overview. Neuropsychobiology, 22, 150–169.

    Article  CAS  PubMed  Google Scholar 

  • Kitayama, S., & Dohi, T. (1996). Cellular and molecular aspects of monoamine neurotransmitter transporters. Japanese Journal of Pharmacology, 72, 195–208.

    Article  CAS  PubMed  Google Scholar 

  • Koenigsberg, H. W., Fan, J., Ochsner, K. N., Liu, X., Guise, K., Pizzarello, S., Dorantes, C., Tecuta, L., Guerreri, S., Goodman, M., New, A., Flory, J., & Siever, L. J. (2010). Neural correlates of using distancing to regulate emotional responses to social situations. Neuropsychologia, 48, 1813–1822.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kunisato, Y., Okamoto, Y., Okada, G., Aoyama, S., Nishiyama, Y., Onoda, K., & Yamawaki, S. (2011). Personality traits and the amplitude of spontaneous low-frequency oscillations during resting state. Neuroscience Letters, 492, 109–113.

    Article  CAS  PubMed  Google Scholar 

  • Lang, P. J., Bradley, M., & Cuthbert, B. N. (2008). International affective picture system (IAPS): affective ratings of pictures and instruction manual. Gainesvill, FL: Technical Report A-8. University of Florida.

    Google Scholar 

  • Laricchiuta, D., Petrosini, L., Piras, F., Cutuli, D., Macci, E., Picerni, E., Chiapponi, C., Caltagirone, C., & Spalletta, G. (2014). Linking novelty seeking and harm avoidance personality traits to basal ganglia: volumetry and mean diffusivity. Brain Structure & Function, 219, 793–803.

    Article  Google Scholar 

  • Lee, K. A., Hicks, G., & Nino-Murcia, G. (1991). Validity and reliability of a scale to assess fatigue. Psychiatry Research, 36, 291–298.

    Article  CAS  PubMed  Google Scholar 

  • Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Muller, C. R., Hamer, D. H., & Murphy, D. L. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527–1531.

    Article  CAS  PubMed  Google Scholar 

  • Maddock, R. J. (1999). The retrosplenial cortex and emotion: new insights from functional neuroimaging of the human brain. Trends in Neurosciences, 22, 310–316.

    Article  CAS  PubMed  Google Scholar 

  • Malliani, A., Pagani, M., Lombardi, F., & Cerutti, S. (1991). Cardiovascular neural regulation explored in the frequency domain. Circulation, 84, 482–492.

    Article  CAS  PubMed  Google Scholar 

  • McEwen, B. S., & Stellar, E. (1993). Stress and the individual. Mechanisms Leading to Disease. Archives of Internal Medicine, 153, 2093–2101.

  • McFarlane, A., Clark, C. R., Bryant, R. A., Williams, L. M., Niaura, R., Paul, R. H., Hitsman, B. L., Stroud, L., Alexander, D. M., & Gordon, E. (2005). The impact of early life stress on psychophysiological, personality and behavioral measures in 740 non-clinical subjects. Journal of Integrative Neuroscience, 4, 27–40.

    Article  PubMed  Google Scholar 

  • Mu, Y., & Han, S. (2010). Neural oscillations involved in self-referential processing. Nuroimage, 53, 757–768.

    Article  Google Scholar 

  • Mula, M., Pini, S., Monteleone, P., Iazzetta, P., Preve, M., Tortorella, A., Amato, E., Di Paolo, L., Conversano, C., Rucci, P., Cassano, G. B., & Maj, M. (2008). Different temperament and character dimensions correlate with panic disorder comorbidity in bipolar disorder and unipolar depression. Journal of Anxiety Disorders, 22, 1421–1426.

    Article  PubMed  Google Scholar 

  • Nakamura, K., Kawashima, R., Sato, N., Nakamura, A., Sugiura, M., Kato, T., Hatano, K., Ito, K., Fukuda, H., Schormann, T., & Zilles, K. (2000). Functional delineation of the human occipito-temporal areas related to face and scene processing. A PET Study. Brain, 123(Pt 9), 1903–1912.

    PubMed  Google Scholar 

  • Pagani, M., Montano, N., Porta, A., Malliani, A., Abboud, F. M., Birkett, C., & Somers, V. K. (1997). Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans. Circulation, 95, 1441–1448.

    Article  CAS  PubMed  Google Scholar 

  • Papanicolaou, A. C., Simos, P. G., Castillo, E. M., Breier, J. I., Sarkari, S., Pataraia, E., Billingsley, R. L., Buchanan, S., Wheless, J., Maggio, V., & Maggio, W. W. (2004). Magnetocephalography: a noninvasive alternative to the wada procedure. Journal of Neurosurgery, 100, 867–876.

    Article  PubMed  Google Scholar 

  • Philip, N. S., Sweet, L. H., Tyrka, A. R., Price, L. H., Carpenter, L. L., Kuras, Y. I., Clark, U. S., & Niaura, R. S. (2013). Early life stress is associated with greater default network deactivation during working memory in healthy controls: a preliminary report. Brain Imaging and Behavior, 7, 204–212.

    Article  PubMed  PubMed Central  Google Scholar 

  • Pomeranz, B., Macaulay, R. J., Caudill, M. A., Kutz, I., Adam, D., Gordon, D., Kilborn, K. M., Barger, A. C., Shannon, D. C., Cohen, R. J., et al. (1985). Assessment of autonomic function in humans by heart rate spectral analysis. The American Journal of Physiology, 248, H151–H153.

    CAS  PubMed  Google Scholar 

  • Pruessner, J. C., Kirschbaum, C., Meinlschmid, G., & Hellhammer, D. H. (2003). Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology, 28, 916–931.

    Article  CAS  PubMed  Google Scholar 

  • Rebai, M., Poiroux, S., Bernard, C., & Lalonde, R. (2001). Event-related potentials for category-specific information during passive viewing of faces and objects. The International Journal of Neuroscience, 106, 209–226.

    Article  CAS  PubMed  Google Scholar 

  • Robinson, P. A., Rennie, C. J., Wright, J. J., Bahramali, H., Gordon, E., & Rowe, D. L. (2001). Prediction of electroencephalographic spectra from neurophysiology. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics, 63, 021903.

    Article  CAS  PubMed  Google Scholar 

  • Rousselet, G. A., Husk, J. S., Bennett, P. J., & Sekuler, A. B. (2008). Time course and robustness of ERP object and face differences. Journal of Vision, 8(3), 1–18.

    Article  Google Scholar 

  • Schlotz, W., Schulz, P., Hellhammer, J., Stone, A. A., & Hellhammer, D. H. (2006). Trait anxiety moderates the impact of performance pressure on salivary cortisol in everyday life. Psychoneuroendocrinology, 31, 459–472.

    Article  CAS  PubMed  Google Scholar 

  • Sekihara, K., & Nagarajan, S. S. (2008). Adaptive spatial filters for electromagnetic brain imaging. Berlin: Springer Verlag.

    Google Scholar 

  • Shigihara, Y., & Zeki, S. (2014). Parallel processing of face and house stimuli by V1 and specialized visual areas: a magnetoencephalographic (MEG) study. Frontiers in Human Neuroscience, 8, 901.

    PubMed  PubMed Central  Google Scholar 

  • Shishida, K., Hashizume, A., Onoda, K., Okamoto, Y., & Yamawaki, S. (2006). Enhanced reactivity and delayed recovery of sensorimotor cortex in the novelty seeking personality. Neuropsychobiology, 54, 215–225.

    Article  PubMed  Google Scholar 

  • Sripada, C. S., Gonzalez, R., Phan, K. L., & Liberzon, I. (2011). The neural correlates of intertemporal decision-making: contributions of subjective value, stimulus type, and trait impulsivity. Human Brain Mapping, 32, 1637–1648.

    Article  PubMed  Google Scholar 

  • Steptoe, A. (1991). Invited review. The Links between Stress and Illness. Journal of Psychosomatic Research, 35, 633–644.

    Article  CAS  PubMed  Google Scholar 

  • Steriade, M. (2000). Corticothalamic resonance, states of vigilance and mentation. Neuroscience, 101, 243–276.

    Article  CAS  PubMed  Google Scholar 

  • Sugiura, M., Kawashima, R., Nakagawa, M., Okada, K., Sato, T., Goto, R., Sato, K., Ono, S., Schormann, T., Zilles, K., & Fukuda, H. (2000). Correlation between human personality and neural activity in cerebral cortex. NeuroImage, 11, 541–546.

    Article  CAS  PubMed  Google Scholar 

  • Svrakic, D. M., Draganic, S., Hill, K., Bayon, C., Przybeck, T. R., & Cloninger, C. R. (2002). Temperament, character, and personality disorders: etiologic, diagnostic, treatment issues. Acta Psychiatrica Scandinavica, 106, 189–195.

    Article  CAS  PubMed  Google Scholar 

  • Tyrka, A. R., Wier, L. M., Price, L. H., Rikhye, K., Ross, N. S., Anderson, G. M., Wilkinson, C. W., & Carpenter, L. L. (2008). Cortisol and ACTH responses to the Dex/CRH test: influence of temperament. Hormones and Behavior, 53, 518–525.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tzagarakis, C., Ince, N. F., Leuthold, A. C., & Pellizzer, G. (2010). Beta-band activity during motor planning reflects response uncertainty. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 30, 11270–11277.

    Article  CAS  Google Scholar 

  • Uhlhaas, P. J., Haenschel, C., Nikolic, D., & Singer, W. (2008). The role of oscillations and synchrony in cortical networks and their putative relevance for the pathophysiology of schizophrenia. Schizophrenia Bulletin, 34, 927–943.

    Article  PubMed  PubMed Central  Google Scholar 

  • Vogele, C., & Steptoe, A. (1993). Anger inhibition and family history as modulators of cardiovascular responses to mental stress in adolescent boys. Journal of Psychosomatic Research, 37, 503–514.

    Article  CAS  PubMed  Google Scholar 

  • Vogt, B. A., & Laureys, S. (2005). Posterior cingulate, precuneal and retrosplenial cortices: cytology and components of the neural network correlates of consciousness. Progress in Brain Research, 150, 205–217.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wiborg, I. M., Falkum, E., Dahl, A. A., & Gullberg, C. (2005). Is harm avoidance an essential feature of patients with panic disorder? Comprehensive Psychiatry, 46, 311–314.

    Article  PubMed  Google Scholar 

  • Yamano, E., Isowa, T., Nakano, Y., Matsuda, F., Hashimoto-Tamaoki, T., Ohira, H., & Kosugi, S. (2008). Association study between reward dependence temperament and a polymorphism in the phenylethanolamine N-methyltransferase gene in a Japanese female population. Comprehensive Psychiatry, 49, 503–507.

    Article  PubMed  Google Scholar 

  • Yoon, S. J., Jun, C. S., An, H. Y., Kang, H. R., & Jun, T. Y. (2009). Patterns of temperament and character in patients with posttraumatic stress disorder and their association with symptom severity. Comprehensive Psychiatry, 50, 226–231.

    Article  PubMed  Google Scholar 

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Acknowledgments

We thank Manryoukai Imaging Clinic for the MRI scans.

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Authors and Affiliations

  1. Department of Physiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka, 545-8585, Japan

    Emi Yamano, Akira Ishii, Masaaki Tanaka & Yasuyoshi Watanabe

  2. Nagaoka University of Technology, 1603-1 Kamitomioka, Nagaoka, 940-2188, Japan

    Shusaku Nomura

  3. RIKEN, Center for Life Science Technologies, 6-7-3 Minatojima-minamimachi, Kobe, Chuo-ku, 650-0047, Japan

    Yasuyoshi Watanabe

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  1. Emi Yamano
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Correspondence to Emi Yamano.

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This study was supported by a Grand-in-Aid for Young Scientists (B) (KAKENHI Grant Number: 25750352) from the Ministry of Education, Culture, Science and Technology (MEXT) of Japan.

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Emi Yamano, Akira Ishii, Masaaki Tanaka, Shusaku Nomura, and Yasuyoshi Watanabe declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Yamano, E., Ishii, A., Tanaka, M. et al. Neural basis of individual differences in the response to mental stress: a magnetoencephalography study. Brain Imaging and Behavior 10, 1160–1171 (2016). https://doi.org/10.1007/s11682-015-9479-0

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